Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Virginie Terraube"'
Autor:
Deirdre Larkin, Bas de Laat, P Vince Jenkins, James Bunn, Alister G Craig, Virginie Terraube, Roger J S Preston, Cynthia Donkor, George E Grau, Jan A van Mourik, James S O'Donnell
Publikováno v:
PLoS Pathogens, Vol 5, Iss 3, p e1000349 (2009)
Plasmodium falciparum infection results in adhesion of infected erythrocytes to blood vessel endothelium, and acute endothelial cell activation, together with sequestration of platelets and leucocytes. We have previously shown that patients with seve
Externí odkaz:
https://doaj.org/article/4b8a3c04cc93410fbb1ff26b879504a5
Autor:
Chuenlei Parng, James S. O’Donnell, Matthew Allister Lambert, Orla Cunningham, Judicael Fazavana, Teresa M. Brophy, Justin Cohen, Alain Chion, Niamh M. Cooke, Jamie M. O’Sullivan, Virginie Terraube, Debra D. Pittman
Publikováno v:
J Thromb Haemost
Background Previous studies have demonstrated that the A1A2A3 domains of von Willebrand factor (VWF) play a key role in regulating macrophage-mediated clearance in vivo. In particular, the A1-domain has been shown to modulate interaction with macroph
Autor:
Matthew Allister Lambert, Simon J. Draper, Orla Cunningham, Stephen Taylor, Niall J. Foy, João Arezes, Susan Benard, Doris Quinkert, Alexander Drakesmith, Reema Jasuja, Edward R. Lavallie, Virginie Terraube, Anagha Sawant, M Tam, Kirsty McHugh, Pasricha S-R., A Brinth, Andrew E. Armitage
Publikováno v:
Blood. 132:1473-1477
Decreased hepcidin mobilizes iron, which facilitates erythropoiesis, but excess iron is pathogenic in beta-thalassemia and other iron-loading anaemias. Erythropoietin (EPO) enhances erythroferrone (ERFE) synthesis by erythroblasts, and ERFE suppresse
Autor:
William S. Somers, Lydia Mosyak, Orla Cunningham, Chao Tu, Amy Tam, Brian J. Fennell, Joel Bard, Edward R. Lavallie, Mark Stahl, Wayne Stochaj, Laura Lin, William J.J. Finlay, Virginie Terraube
Publikováno v:
Journal of Biological Chemistry. 291:1267-1276
Fully-human single-chain Fv (scFv) proteins are key potential building blocks of bispecific therapeutic antibodies, but they often suffer from manufacturability and clinical development limitations such as instability and aggregation. The causes of t
Autor:
Alain Chan, Virginie Terraube, Jamie M. O’Sullivan, James S. O’Donnell, Justin Cohen, Matthew Allister Lambert, Judicael Fazavana, Debra D. Pittman, Niamh M. Cooke, Orla Cunningham
Publikováno v:
Blood. 132:1165-1165
Introduction Deficiencies of both von Willebrand Factor (VWF) and FVIII are associated with significant bleeding phenotypes. Consequently, patients with VWD or hemophilia A commonly require replacement therapy with coagulation factor concentrates. Ho
Autor:
Barry J. Byrne, Emily McRae, James S. O’Donnell, Richard O'Kennedy, Michael Laffan, Rachel T. McGrath, Virginie Terraube, Roger J. S. Preston, Thomas A. J. McKinnon
Publikováno v:
Blood. 115:2666-2673
von Willebrand factor (VWF) multimeric composition is regulated in plasma by ADAMTS13. VWF deglycosylation enhances proteolysis by ADAMTS13. In this study, the role of terminal sialic acid residues on VWF glycans in mediating proteolysis by ADAMTS13
Autor:
Olivier D. Christophe, Shirin Shahbazi, Virginie Terraube, Peter J. Lenting, C. Fribourg, Cécile V. Denis
Publikováno v:
Journal of Thrombosis and Haemostasis. 5:1956-1962
Summary. Background and objective: Osteoprotegerin (OPG), a member of the tumor necrosis-factor receptor superfamily, plays an important role in bone remodeling and is also involved in vascular diseases. OPG is physically associated with von Willebra
Autor:
Philip G. de Groot, Virginie Terraube, Peter J. Lenting, Olivier D. Christophe, Cécile V. Denis, Ronan Pendu, Carl G. Gahmberg
Publikováno v:
University of Helsinki
Von Willebrand factor (VWF) is an essential component of hemostasis. However, animal studies using VWF-deficient mice suggest that VWF may also contribute to inflammation. In the present study, we demonstrate that VWF was able to interact with polymo
Autor:
Ronan Pendu, Cécile V. Denis, Virginie Terraube, Peter J. Lenting, Dominique Baruch, Dominique Meyer, Martijn F.B.G. Gebbink
Publikováno v:
Journal of Thrombosis and Haemostasis. 4:519-526
Summary. Background: The key role played by von Willebrand factor (VWF) in platelet adhesion suggests a potential implication in various pathologies, where this process is involved. In cancer metastasis development, tumor cells interact with platelet
Publikováno v:
Haemophilia : the official journal of the World Federation of Hemophilia. 16(1)
The interaction of factor VIII (FVIII) with von Willebrand Factor (VWF) is of direct clinical significance in the diagnosis and treatment of patients with haemophilia A and von Willebrand disease (VWD). A normal haemostatic response to vascular injur