Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Virginie Sanguin‐Gendreau"'
Autor:
Yu Gu, Tarek Taifour, Tung Bui, Dongmei Zuo, Alain Pacis, Alexandre Poirier, Sherif Attalla, Anne-Marie Fortier, Virginie Sanguin-Gendreau, Tien-Chi Pan, Vasilios Papavasiliou, Nancy U. Lin, Melissa E. Hughes, Kalie Smith, Morag Park, Michel L. Tremblay, Lewis A. Chodosh, Rinath Jeselsohn, William J. Muller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Recurrent breast cancers often develop resistance to standard-of-care therapies. Identifying targetable factors contributing to cancer recurrence remains the rate-limiting step in improving long-term outcomes. In this study, we identify tumo
Externí odkaz:
https://doaj.org/article/ce14835d262d4ceaae4ee74374578c4b
Autor:
Ipshita Nandi, Linjia Ji, Harvey W. Smith, Daina Avizonis, Vasilios Papavasiliou, Cynthia Lavoie, Alain Pacis, Sherif Attalla, Virginie Sanguin-Gendreau, William J. Muller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Metabolic reprogramming, a hallmark of tumorigenesis, involves alterations in glucose and fatty acid metabolism. Here, we investigate the role of Carnitine palmitoyl transferase 1a (Cpt1a), a key enzyme in long-chain fatty acid (LCFA) oxidat
Externí odkaz:
https://doaj.org/article/052dee2b00604ae3ada71ece23a9fb36
Autor:
Catherine R. Dufour, Hui Xia, Wafa B’chir, Marie-Claude Perry, Uros Kuzmanov, Anastasiia Gainullina, Kurt Dejgaard, Charlotte Scholtes, Carlo Ouellet, Dongmei Zuo, Virginie Sanguin-Gendreau, Christina Guluzian, Harvey W. Smith, William J. Muller, Etienne Audet-Walsh, Alexey A. Sergushichev, Andrew Emili, Vincent Giguère
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Murine hearts deficient in ErbB2 and/or ERRα are used to profile the adverse cardiac remodeling associated with potential targeted breast cancer treatments by phosphoproteomic, transcriptomic and metabolomic profiling.
Externí odkaz:
https://doaj.org/article/ddcceb39187b47f3a0dc86d4bc298e2e
Autor:
Ipshita Nandi, Harvey W. Smith, Virginie Sanguin-Gendreau, Linjia Ji, Alain Pacis, Vasilios Papavasiliou, Dongmei Zuo, Stella Nam, Sherif S. Attalla, Sung Hoon Kim, Sierra Lusson, Hellen Kuasne, Anne-Marie Fortier, Paul Savage, Constanza Martinez Ramirez, Morag Park, John A. Katzenellenbogen, Benita S. Katzenellenbogen, William J. Muller
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
Activation of the tyrosine kinase c-Src promotes breast cancer progression and poor outcomes, yet the underlying mechanisms are incompletely understood. Here, we have shown that deletion of c-Src in a genetically engineered model mimicking the lumina
Externí odkaz:
https://doaj.org/article/6febccb2e0664106aef4e61bab5617dd
Autor:
Jason Sadek, Derek T Hall, Bianca Colalillo, Amr Omer, Anne‐Marie K Tremblay, Virginie Sanguin‐Gendreau, William Muller, Sergio Di Marco, Marco Emilio Bianchi, Imed‐Eddine Gallouzi
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 7, Pp 1-24 (2021)
Abstract Cachexia syndrome develops in patients with diseases such as cancer and sepsis and is characterized by progressive muscle wasting. While iNOS is one of the main effectors of cachexia, its mechanism of action and whether it could be targeted
Externí odkaz:
https://doaj.org/article/50ee8d2abc6a43eda880e459f9956f4e
Autor:
Harvey W. Smith, Alison Hirukawa, Virginie Sanguin-Gendreau, Ipshita Nandi, Catherine R. Dufour, Dongmei Zuo, Kristofferson Tandoc, Matthew Leibovitch, Salendra Singh, Jonathan P. Rennhack, Matthew Swiatnicki, Cynthia Lavoie, Vasilios Papavasiliou, Carolin Temps, Neil O. Carragher, Asier Unciti-Broceta, Paul Savage, Mark Basik, Vincent van Hoef, Ola Larsson, Caroline L. Cooper, Ana Cristina Vargas Calderon, Jane Beith, Ewan Millar, Christina Selinger, Vincent Giguère, Morag Park, Lyndsay N. Harris, Vinay Varadan, Eran R. Andrechek, Sandra A. O’Toole, Ivan Topisirovic, William J. Muller
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Polycomb Repressor Complex 2 (PRC2) is frequently up-regulated in cancers. Here, the authors show that the tyrosine kinase c-Src stimulates mitochondrial function to signal energy sufficiency to mTORC1, increasing translation of the PRC2 subunits EZH
Externí odkaz:
https://doaj.org/article/4b4ac9959bb3404bb739e2634c53409f
Autor:
Alison Hirukawa, Salendra Singh, Jarey Wang, Jonathan P. Rennhack, Matthew Swiatnicki, Virginie Sanguin-Gendreau, Dongmei Zuo, Kamilia Daldoul, Cynthia Lavoie, Morag Park, Eran R. Andrechek, Thomas F. Westbrook, Lyndsay N. Harris, Vinay Varadan, Harvey W. Smith, William J. Muller
Publikováno v:
Cell Reports, Vol 29, Iss 2, Pp 249-257.e8 (2019)
Summary: Monoclonal antibodies (mAbs) targeting the oncogenic receptor tyrosine kinase ERBB2/HER2, such as Trastuzumab, are the standard of care therapy for breast cancers driven by ERBB2 overexpression and activation. However, a substantial proporti
Externí odkaz:
https://doaj.org/article/d72321d9dd27483ea95dfcd6db827f5b
Autor:
Alexandra M. Simond, Tung Bui, Dongmei Zuo, Virginie Sanguin-Gendreau, Trisha Rao, Wayne A. Phillips, Robert D. Cardiff, William J. Muller
Publikováno v:
Oncogene. 41:3445-3451
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc981c6752b1ed074f396ade467bce84
https://doi.org/10.1038/s41388-022-02323-9
https://doi.org/10.1038/s41388-022-02323-9
Autor:
William J. Muller, Jim C. Norman, Douglas Strathdee, Lewis Chodosh, Morag Park, Gordon B. Mills, Michael Hallett, Shirley Campbell, Julie M. Livingstone, Shreya Mitra, Laura Jones, Virginie Sanguin-Gendreau, Cynthia Lavoie, Julie-Émilie Huot-Marchand, Jason Turpin, Louise Mitchell, Pierre-Luc Boulay
This Supplemental Figure 1 describes engineering of FIP1C inducible mouse model and condition knockout. Moreover, Supplemental Figure 1 provides data related to the elucidation of the physiological role of FIP1C during mamamry gland outgrowth as a su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9049d89bb7d02e3dfbe5b4aac02be0e3
https://doi.org/10.1158/0008-5472.22412007.v1
https://doi.org/10.1158/0008-5472.22412007.v1
Autor:
William J. Muller, Jim C. Norman, Douglas Strathdee, Lewis Chodosh, Morag Park, Gordon B. Mills, Michael Hallett, Shirley Campbell, Julie M. Livingstone, Shreya Mitra, Laura Jones, Virginie Sanguin-Gendreau, Cynthia Lavoie, Julie-Émilie Huot-Marchand, Jason Turpin, Louise Mitchell, Pierre-Luc Boulay
The Supplemental Figure 4 consists in key additionnal data sets to support and supplement Figure 5. Briefly, this supplemental figure 4 shows immunohistochemistry staining performed on FIP1C-MTB-NDL and NIC/FIP1C mammary tumors to examine activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2bc3f6fcd2599559cb809a50a3fc7c
https://doi.org/10.1158/0008-5472.22411998
https://doi.org/10.1158/0008-5472.22411998