Metabolic landscapes in sarcomas

Autor: Richard Miallot, Franck Galland, Virginie Millet, Jean-Yves Blay, Philippe Naquet

Publikováno v: Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-23 (2021)

Abstract Metabolic rewiring offers novel therapeutic opportunities in cancer. Until recently, there was scant information regarding soft tissue sarcomas, due to their heterogeneous tissue origin, histological definition and underlying genetic history

Externí odkaz: https://doaj.org/article/7d99a7f23c364f748d9c85b92e3ecc41

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An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity

Autor: Richard Miallot, Virginie Millet, Yann Groult, Angelika Modelska, Lydie Crescence, Sandrine Roulland, Sandrine Henri, Bernard Malissen, Nicolas Brouilly, Laurence Panicot-Dubois, Renaud Vincentelli, Gerlind Sulzenbacher, Pascal Finetti, Aurélie Dutour, Jean-Yves Blay, François Bertucci, Franck Galland, Philippe Naquet

Publikováno v: Life Science Alliance
Life Science Alliance, 2023, 6, ⟨10.26508/lsa.202201767⟩

Aggressive tumors often display mitochondrial dysfunction. Upon oxidative stress, mitochondria undergo fission through OMA1-mediated cleavage of the fusion effector OPA1. In yeast, a redox-sensing switch participates in OMA1 activation. 3D modeling o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6e871feae11b35998d7f8bc002d2c3
https://hal.science/hal-04066238

Serum Pantetheinase/Vanin Levels Regulate Erythrocyte Homeostasis and Severity of Malaria

Autor: Carlos Penha-Gonçalves, Philippe Naquet, Maria Rosário Sambo, Virginie Millet, Annie Viallat, Carole Beaumont, Emmanuèle Helfer, Lionel Chasson, Samuel Rommelaere, Giovanna Chimini, Franck Galland, Scott Atwell, Pascal Rihet

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
American Journal of Pathology
American Journal of Pathology, American Society for Investigative Pathology, 2015, 185 (11), pp.3039-3052. ⟨10.1016/j.ajpath.2015.07.011⟩
American Journal of Pathology, 2015, 185 (11), pp.3039-3052. ⟨10.1016/j.ajpath.2015.07.011⟩

This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3001de2261cdfb9785a02d433b6cb09c

Sox17 regulates liver lipid metabolism and adaptation to fasting

Autor: Bart Staels, Bertrand Escalière, Thomas Gensollen, Christophe Bourges, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Yoshiakira Kanai, Bernard Malissen, Marie Malissen, Anne Tailleux, Franck Galland, Yu Xia, Bruce Beutler, Virginie Millet, Thien Phong Vu Manh, Xin Du, Philippe Naquet, Jean Imbert, Samuel Rommelaere

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e104925 (2014)
PLoS ONE

Liver is a major regulator of lipid metabolism and adaptation to fasting, a process involving PPARalpha activation. We recently showed that the Vnn1 gene is a PPARalpha target gene in liver and that release of the Vanin-1 pantetheinase in serum is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95cecb358eb5a284a343af47b9d268a
http://europepmc.org/articles/PMC4139292?pdf=render