Výsledky vyhledávání - "Virginie Le Brun"

Industry Perspective on the Use and Characterization of Polysorbates for Biopharmaceutical Products Part 2: Survey Report on Control Strategy Preparing for the Future

Publikováno v: Journal of Pharmaceutical Sciences. 111:2955-2967

Polysorbate (PS) 20 and 80 are the main surfactants used to stabilize biopharmaceutical products. Industry practices on various aspects of PS based on a confidential survey and following discussions by 16 globally acting major biotechnology companies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea8521e83744774d4dca728dc73db0b
https://doi.org/10.1016/j.xphs.2022.08.021

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Industry Perspective on the use and Characterization of Polysorbates for Biopharmaceutical Products Part 1: Survey Report on Current State and Common Practices for Handling and Control of Polysorbates

Publikováno v: Journal of pharmaceutical sciences. 111(5)

Polysorbates (PS) are widely used as a stabilizer in biopharmaceutical products. Industry practices on various aspects of PS are presented in this part 1 survey report based on a confidential survey and following discussions by 16 globally acting maj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fabf14b911f2e159c164b7a11a62373
https://pubmed.ncbi.nlm.nih.gov/35192858

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Correlation of protein-protein interactions as assessed by affinity chromatography with colloidal protein stability: a case study with lysozyme

Autor: Stefan Bassarab, Patrick Garidel, Wolfgang Friess, Virginie Le Brun

Publikováno v: Pharmaceutical development and technology. 15(4)

Lysozyme-lysozyme interactions were assessed in the native state at 25 degrees C as well in the denatured state at 80 degrees C by affinity chromatography in order to measure the osmotic second virial coefficient (B). This parameter allows us to bett

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592ae4a8fe8ade66234c4eb63915d112
https://pubmed.ncbi.nlm.nih.gov/19780642

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Lysozyme-lysozyme self-interactions as assessed by the osmotic second virial coefficient: impact for physical protein stabilization

Autor: Patrick Garidel, Wolfgang Friess, Silke Muehlau, Virginie Le Brun, Torsten Schultz-Fademrecht

Publikováno v: Biotechnology journal. 4(9)

The purpose of the presented study is to understand the physicochemical properties of proteins in aqueous solutions in order to identify solution conditions with reduced attractive protein-protein interactions, to avoid the formation of protein aggre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e911a4ab94453c359eb1a7056ce38309
https://pubmed.ncbi.nlm.nih.gov/19579219

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A critical evaluation of self-interaction chromatography as a predictive tool for the assessment of protein-protein interactions in protein formulation development: a case study of a therapeutic monoclonal antibody

Autor: Patrick Garidel, Virginie Le Brun, Wolfgang Friess, Stefan Bassarab, Silke Mühlau

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 75(1)

The aim of this study was to establish and evaluate a screening method for the physical characterization of protein–protein interactions of therapeutic proteins based on the determination of the osmotic second virial coefficient (B 22 ). B 22 of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f19b7ea4cbcfa4f5326e04111a9517
https://pubmed.ncbi.nlm.nih.gov/20102739

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