A Convergent Approach to (−)-Callystatin A Based on Local Symmetry

Autor: Jean-Marc Pons, Cyril Bressy, Sabrina Parat, Mathieu Candy, Hugues Bienaymé, Loïc Tomas, Virginie Héran

Publikováno v: Chemistry - A European Journal. 18:14267-14271

The key is symmetry! A convergent synthetic approach of the highly cytotoxic natural product (-)-callystatin A was developed assembling three fragments through Julia-Kocienski olefination and Stille cross-coupling. The new strategy relies on a pivota

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc77bf1ebe4bf587684e5a1cda16a3ba
https://doi.org/10.1002/chem.201202701

Carboxylate-Directed Tandem Functionalizations of α,β-Dihaloalkenoic Acids with 1-Alkynes: A Straightforward Access to (Z)-Configured, α,β-Substituted γ-Alkylidenebutenolides

Autor: Mohamed Abarbri, Jérôme Thibonnet, Jean-Luc Parrain, A. Duchene, Samuel Inack Ngi, Khalil Cherry, Laurent Commeiras, Virginie Héran

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2011, 17 (49), pp.13692-13696. ⟨10.1002/chem.201102570⟩
Chemistry-A European Journal, 2011, 17 (49), pp.13692-13696. ⟨10.1002/chem.201102570⟩

International audience; An easy and mild copper(I)-catalysed lactonisation of readily available (E)-2,3-dihalopropenoic acid derivatives regio- and stereoselectively leads to rarely described (Z)-3-halo-5-ylidene-5H-furan-2-ones. These compounds are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae12b1462441108d15c2c4ab4fdc49ff
https://hal.archives-ouvertes.fr/hal-00738084

Micro-confinement of bacteria into w/o emulsion droplets for rapid detection and enumeration

Autor: Raphael Mathey, Frédéric Mallard, Mathieu Dupoy, Armelle Novelli-Rousseau, Jean-Pierre Moy, Florence Rivera, Sophie Morales, Pierre Marcoux, Virginie Héran, Pierre L. Joly

Publikováno v: Colloids and Surfaces A: Physicochemical and Engineering Aspects
Colloids and Surfaces A: Physicochemical and Engineering Aspects, Elsevier, 2011, 377, pp.54-62. ⟨10.1016/j.colsurfa.2010.12.013⟩
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2011, 377, pp.54-62. ⟨10.1016/j.colsurfa.2010.12.013⟩

Today, rapid detection and identification of bacteria in microbiological diagnosis is a major issue. Reference methods usually rely on growth of microorganisms, with the drawback of lengthy time-to-result. The method provides global information on a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6520bc53c99adba79a23b3186eb9abd
https://hal-cea.archives-ouvertes.fr/cea-00822878/document

Dramatic influence of the substitution of alkylidene-5H-furan-2-ones in Diels–Alder cycloadditions with o-quinonedimethide as diene partner: en route to the CDEF polycyclic ring system of lactonamycin

Autor: Romain Blanc, Jérôme Thibonnet, Sébastien Dubois, Virginie Héran, Jean-Luc Parrain, Raphaël Rahmani, Fabien Rodier, Laurent Commeiras

Publikováno v: Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2012, 10, pp.4712-4719. ⟨10.1039/c2ob25299f⟩
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2012, 10, pp.4712-4719. ⟨10.1039/c2ob25299f⟩

International audience; An efficient and rapid synthesis of the CDEF ring system of lactonamycinone is reported via a highly chemo- and diastereoselective intermolecular Diels-Alder cycloaddition between trans-1,2- disilyloxybenzocyclobutene and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d158bb3ed8841aab7053aad3622126
https://doi.org/10.1039/c2ob25299f