Systemic administration of cationic phosphonolipids/DNA complexes and the relationship between formulation and lung transfection efficiency

Autor: J.P. Leroy, S. Loisel, Claude Férec, Virginie Floch, Christine Guillaume, E Gobin, Pascal Delépine, S. Chassé, G Le Bolch

Publikováno v: Biochimica et Biophysica Acta:Biomembranes
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2000, 1464, pp.95--103. ⟨10.1016/S0005-2736(99)00250-3⟩

International audience; Performances of cationic lipid formulations for intravenous gene delivery to mouse lungs have been previously reported. We report in this study that cationic phosphonolipids, when appropriately formulated, can be good syntheti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705f43eb5a56364c662ecb9ad11ce8b2
https://doi.org/10.1016/s0005-2736(99)00250-3

Cationic Phosphonolipids as Nonviral Gene Transfer Agents in the Lungs of Mice

Autor: Jean-Jacques Yaouanc, J.P. Leroy, E Gobin, Claude Férec, Virginie Floch, J.‐C. Clement, Marie-Pierre Audrézet, Bernard Mercier, H. Des Abbayes, G Le Bolch, V Morin, C Guillaume-Gable

Publikováno v: Human Gene Therapy. 9:2309-2319

With the aim of developing new gene transfer tools for treating CF with gene therapy, we have synthesized a novel family of molecules named cationic phosphonolipids. The most efficient among them were selected by in vitro screening to compare their a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6656e3ad4131717285f91a3e25f5007
https://doi.org/10.1089/hum.1998.9.16-2309

Novel Cationic Phosphonolipids Agents for in Vitro Gene Transfer to Epithelial Cell Lines

Autor: Jean-Jacques Yaouanc, Arpita Paul, Claude Férec, Virginie Floch, J.‐C. Clement, G Le Bolch, Marie-Pierre Audrézet, Bernard Mercier, H. Des Abbayes

Publikováno v: Journal of Liposome Research. 7:273-300

The use of cationic liposomes is one of the main approaches currently investigated to introduce into a cell a gene with therapeutic properties. This study presents in vitro results obtained with a new family of gene transfer agents, the phosphonolipi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67024dd0a76a7d1ac167c3017e12ed62
https://doi.org/10.3109/08982109709035502

Cationic Phosphonolipids Containing Quaternary Phosphonium and Arsonium Groups for DNA Transfection with Good Efficiency and Low Cellular Toxicity**

Autor: Jean-Claude Clément, Jean-Jacques Yaouanc, Séverine Loisel, Virginie Floch, Erwann Guénin, Anne-Cécile Hervé, Hervé des Abbayes, Claude Férec

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2000, 39, pp.629--631. ⟨10.1002/(SICI)1521-3773(20000204)39:33.0.CO;2-K⟩

International audience; Replacing the ammonium polar head in cationic lipids 1 (A = N) by a phosphonium or an arsonium group (A=P, As) improves their properties as synthetic vectors for DNA transfection. The increased volume of the cationic head is s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3ceae4f1e7c927cd231d935082e85c
https://doi.org/10.1002/(sici)1521-3773(20000204)39:3<629::aid-anie629>3.0.co

Cation substitution in cationic phosphonolipids: a new concept to improve transfection activity and decrease cellular toxicity

Autor: Herve Des Abbayes, Anne Hervé, Virginie Floch, Claude Ferec, Jean Jacques Yaouanc, Jean Claude Clement, Séverine Loisel, Erwann Guénin

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2000, 43, pp.4617--4628. ⟨10.1021/jm000006z⟩

International audience; Cationic lipids have been shown to be an interesting alternative to viral vector-mediated gene delivery into in vitro and in vivo model applications. Prior studies have demonstrated that even minor structural modifications of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912d05ae3a32d83adec37f02f33f942b
https://pubmed.ncbi.nlm.nih.gov/11101353