Evaluation of the safety and efficacy of XAV-19 in patients with COVID-19-induced moderate pneumonia: study protocol for a randomized, double-blinded, placebo-controlled phase 2 (2a and 2b) trial

Autor: Benjamin Gaborit, Bernard Vanhove, Marie-Anne Vibet, Aurélie Le Thuaut, Karine Lacombe, Vincent Dubee, Florence Ader, Virginie Ferre, Eric Vicaut, Jéremie Orain, Morgane Le Bras, Anne Omnes, Laetitia Berly, Alexandra Jobert, Pascale Morineau-Le Houssine, Karine Botturi, Régis Josien, Laurent Flet, Nicolas Degauque, Sophie Brouard, Odile Duvaux, Alexandra Poinas, François Raffi, POLYCOR study group

Publikováno v: Trials, Vol 22, Iss 1, Pp 1-17 (2021)

Abstract Background Early inhibition of entry and replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a very promising therapeutic approach. Polyclonal neutralizing antibodies offers many advantages such as providing im

Externí odkaz: https://doaj.org/article/c0680748f60346049915c615da5ecaca

Factors associated with the emergence of integrase resistance mutations in patients failing dual or triple integrase inhibitor-based regimens in a French national survey

Autor: Anne-Genevieve, Marcelin, Charlotte, Charpentier, Pantxika, Bellecave, Basma, Abdi, Marie-Laure, Chaix, Virginie, Ferre, Stephanie, Raymond, Djeneba, Fofana, Laurence, Bocket, Audrey, Mirand, Helene, Le Guillou-Guillemette, Brigitte, Montes, Corinne, Amiel, Coralie, Pallier, Samira, Fafi-Kremer, Anne, De Monte, Elodie, Alessandri-Gradt, Caroline, Scholtes, Anne, Maillard, Helene, Jeulin, Magali, Bouvier-Alias, Catherine, Roussel, Georges, Dos Santos, Anne, Signori-Schmuck, Julia, Dina, Sophie, Vallet, Karl, Stefic, Cathia, Soulié, Vincent, Calvez, Diane, Descamps, Philippe, Flandre, S, Marque Juillet

Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, 2021, 76 (9), pp.2400-2406. ⟨10.1093/jac/dkab193⟩
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2021, 76 (9), pp.2400-2406. ⟨10.1093/jac/dkab193⟩

Background Successful 2-drug regimens (2DRs) for HIV were made possible by the availability of drugs combining potency and tolerability with a high genetic barrier to resistance. How these deal with resistance development/re-emergence, compared with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa49d408326ea60eb280da50f193208
https://pubmed.ncbi.nlm.nih.gov/34100068

Use of reverse transcription polymerase chain reaction with colorimetric plate hybridization to detect a cytomegalovirus late spliced mRNA in polymorphonuclear leukocytes from renal transplant patients

Autor: Diego Cantarovich, Virginie Ferre-Aubineau, Bernard Besse, Sylviane Billaudel, Berthe-Marie Imbert-Marcille, Elisabeth Andre

Publikováno v: Diagnostic Microbiology and Infectious Disease. 34:287-291

Human cytomegalovirus replication was evaluated in polymorphonuclear leukocytes from ten renal transplant recipients. Three new reverse transcription polymerase chain reactions with plate hybridization suitable for automation were developed for the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05effe80a3612290968ead301505cac0
https://doi.org/10.1016/s0732-8893(99)00043-7

Impact of lopinavir/ritonavir use on antiretroviral resistance in recent clinical practice

Autor: Sidonie, Lambert-Niclot, Bernard, Masquelier, Isabelle, Cohen Codar, Cathia, Soulie, Constance, Delaugerre, Laurence, Morand-Joubert, Charlotte, Charpentier, Virginie, Ferre, Jean-Christophe, Plantier, Brigitte, Montes, Sophie, Carret, Valerie, Perrot, Gilles, Peytavin, Dominique, Costagliola, Vincent, Calvez, Anne-Geneviève, Marcelin, A, Si-Mohamed

Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, 2012, 67 (10), pp.2487-2493. ⟨10.1093/jac/dks226⟩
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2012, 67 (10), pp.2487-2493. ⟨10.1093/jac/dks226⟩

International audience; Objectives This observational study was requested by French health authorities to determine the impact of lopinavir/ritonavir (Kaletra®) on antiretroviral resistance in clinical practice. Virological failures of lopinavir/rit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c4ef2d0da2883698c2218dc6d44a0f
https://pubmed.ncbi.nlm.nih.gov/22733652

Cellular normalization of viral DNA loads on whole blood improves the clinical management of cytomegalovirus or Epstein Barr virus infections in the setting of pre-emptive therapy

Autor: Céline, Bressollette-Bodin, Marianne, Coste-Burel, Bernard, Besse, Elisabeth, André-Garnier, Virginie, Ferre, Berthe-Marie, Imbert-Marcille

Publikováno v: Journal of medical virology. 81(1)

Two quantitative duplex real-time PCR assays were developed for co-amplification of human albumin and cytomegalovirus (CMV) or Epstein Barr virus (EBV) genes after automated extraction on whole blood, and compared two units for expressing viral DNA l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22d31ba925e8b1e9c326c238137fbb59
https://pubmed.ncbi.nlm.nih.gov/19031462