Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Virginie Boucherit"'
1
Akademický článek
Replication gap suppression depends on the double-strand DNA binding activity of BRCA2
Autor: Domagoj Vugic, Isaac Dumoulin, Charlotte Martin, Anna Minello, Lucia Alvaro-Aranda, Jesus Gomez-Escudero, Rady Chaaban, Rana Lebdy, Catharina von Nicolai, Virginie Boucherit, Cyril Ribeyre, Angelos Constantinou, Aura Carreira
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Here the authors demonstrate that the dsDNA binding function at the N-terminus of BRCA2 prevents nucleotide depletion-dependent replicative ssDNA gaps but not those induced by PARP inhibition. This function is impaired in breast-cancer variants affec
Externí odkaz: https://doaj.org/article/da096cea1a02470f8a2851555746cfb7
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2
Akademický článek
The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal
Autor: Karol Kramarz, Kamila Schirmeisen, Virginie Boucherit, Anissia Ait Saada, Claire Lovo, Benoit Palancade, Catherine Freudenreich, Sarah A. E. Lambert
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
In yeast, collapsed forks shift to the nuclear periphery to associate with two distinct perinuclear anchorage sites such as the nuclear pore complex. Here, the authors reveal the mechanisms engaged at nuclear pore complex facilitating fork integrity
Externí odkaz: https://doaj.org/article/b024f89b69c54014a61545e22ef45604
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3
Akademický článek
Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1
Autor: Åsa Ehlén, Charlotte Martin, Simona Miron, Manon Julien, François-Xavier Theillet, Virginie Ropars, Gaetana Sessa, Romane Beaurepere, Virginie Boucherit, Patricia Duchambon, Ahmed El Marjou, Sophie Zinn-Justin, Aura Carreira
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
The BRCA2 tumour suppressor protein is known to play an important role in homologous recombination. Here the authors reveal how the phosphorylation of BRCA2 by Polo-like kinase 1 (PLK1) contributes to the regulation of mitosis.
Externí odkaz: https://doaj.org/article/1172298aed5c403d86de4c53b25b80bd
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4
RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation
Autor: Charlotte Audoynaud, Kamila Schirmeisen, Anissia Ait Saada, Armelle Gesnik, Paloma Fernández-Varela, Virginie Boucherit, Virginie Ropars, Anusha Chaudhuri, Karine Fréon, Jean-Baptiste Charbonnier, Sarah A.E. Lambert
Publikováno v: Molecular Cell
Molecular Cell, 2023, 83 (7), pp.1061-1074.e6. ⟨10.1016/j.molcel.2023.02.008⟩
International audience; Non-homologous end-joining (NHEJ) factors act in replication fork protection, restart and repair. Here, we identified a mechanism related to RNA:DNA hybrids to establish the NHEJ factor Ku-mediated barrier to nascent strand de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74675ee7f580d189558526c9f5ee5af7
https://doi.org/10.1016/j.molcel.2023.02.008
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5
Deubiquitinase USP8 targets ESCRT-III to promote incomplete cell division
Autor: Juliette Mathieu, Pascale Michel-Hissier, Virginie Boucherit, Jean-René Huynh
Publikováno v: Science
Science, 2022, 376 (6595), pp.818-823. ⟨10.1126/science.abg2653⟩
In many vertebrate and invertebrate organisms, gametes develop within groups of interconnected cells called germline cysts formed by several rounds of incomplete divisions. We found that loss of the deubiquitinase USP8 gene in Drosophila can transfor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649b3ee62967635e3a284a79db039b50
https://hal-cnrs.archives-ouvertes.fr/hal-03707138/document
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8
The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal
Autor: Virginie Boucherit, Catherine H. Freudenreich, Benoit Palancade, Sarah Lambert, Anissia Ait Saada, Karol Kramarz, Kamila Schirmeisen, Claire Lovo
Publikováno v: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-19516-z⟩
Nuclear Pore complexes (NPCs) act as docking sites to anchor particular DNA lesions facilitating DNA repair by elusive mechanisms. Using replication fork barriers in fission yeast, we report that relocation of arrested forks to NPCs occurred after Ra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fe6c1c14b7e24bd63b69f4bb7c190d
http://europepmc.org/articles/PMC7648084
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9
Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1
Autor: Charlotte Martin, Simona Miron, Åsa Ehlén, Patricia Duchambon, Aura Carreira, Virginie Ropars, Manon Julien, Francois Xavier Theillet, Sophie Zinn-Justin, Romane Beaurepere, Virginie Boucherit, Ahmed El Marjou, Gaetana Sessa
Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.1819. ⟨10.1038/s41467-020-15689-9⟩
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Nature Communications, 2020, 11 (1), pp.1819. ⟨10.1038/s41467-020-15689-9⟩
The BRCA2 tumor suppressor protein is involved in the maintenance of genome integrity through its role in homologous recombination. In mitosis, BRCA2 is phosphorylated by Polo-like kinase 1 (PLK1). Here we describe how this phosphorylation contribute
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef495fe5918c6769cc4c07a7a31313bd
https://hal.archives-ouvertes.fr/hal-02547881/document
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