Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Virginie, Sippel"'
Autor:
Daniel S Strasser, Estelle Gerossier, Virginie Sippel, Ursula Grieder, Andrea Kieninger-Graefitsch, Sylvie Froidevaux, Marten Trendelenburg, Gabin M Pierlot, Enrico Vezzali, Anna K Stalder, Bérengère Renault, Jesper Ryge, Aaron Hart, Ulrich Mentzel, Peter M A Groenen, Marcel P Keller, Marianne M Martinic, Mark J Murphy
Publikováno v:
RMD Open, Vol 6, Iss 2 (2020)
Objectives: SLE is an autoimmune disease characterised by aberrant lymphocyte activation and autoantibody production. This study provides an in-depth preclinical and clinical characterisation of the treatment effect of cenerimod, a sphingosine-1-phos
Externí odkaz:
https://doaj.org/article/74b13847b7f044e2be8ad1ab498686fc
Autor:
Ulrich Mentzel, Estelle Gerossier, Virginie Sippel, Anna K. Stalder, Enrico Vezzali, Aaron Hart, Peter M.A. Groenen, Gabin M Pierlot, Ursula Grieder, Bérengère Renault, Mark Murphy, Marten Trendelenburg, Jesper Ryge, Marianne M Martinic, Andrea Kieninger-Graefitsch, Daniel S. Strasser, Marcel P Keller, Sylvie Froidevaux
Publikováno v:
RMD Open, Vol 6, Iss 2 (2020)
Both B and T lymphocytes have been implicated in playing a major role in the pathogenesis of systemic lupus erythematosus (SLE), a complex and heterogeneous autoimmune disease of unknown aetiology, characterised by the production of high titres of pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe94a1b11535c312c31a78a074fbc70e
https://rmdopen.bmj.com/content/6/2/e001261.full
https://rmdopen.bmj.com/content/6/2/e001261.full
Autor:
Marten Trendelenburg, Andrea Kieninger-Graefitsch, Gabin M Pierlot, Marcel P Keller, Daniel S. Strasser, Estelle Gerossier, Marianne M Martinic, Sylvie Froidevaux, Virginie Sippel, Paulina Kulig, Ursula Grieder, Hervé Farine, Mark Murphy
Publikováno v:
Poster presentations.
Background Reported here is the characterization of cenerimod, a novel, potent, selective, and orally active sphingosine-1-phosphate receptor 1 (S1P1) modulator in the context of SLE. Methods Lymphocytes from patients with SLE and healthy subjects we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9b1f33c5c9da3ebf5c1fe7cfa984903
https://doi.org/10.1136/lupus-2020-eurolupus.182
https://doi.org/10.1136/lupus-2020-eurolupus.182
Autor:
Daniel S Strasser, Estelle Gerossier, Virginie Sippel, Ursula Grieder, Andrea Kieninger-Graefitsch, Gabin Pierlot, Hervé Farine, Paulina Kulig, Marcel Keller, Sylvie Froidevaux, Marten Trendelenburg, Mark Murphy, Marianne Martinic
Publikováno v:
Oral presentations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4befd8435ec8372ff097a1324a1f8c74
https://doi.org/10.1136/lupus-2020-eurolupus.49
https://doi.org/10.1136/lupus-2020-eurolupus.49
Publikováno v:
European Journal of Molecular and Clinical Medicine, Vol 5, Iss 1, Pp 1-11 (2018)
Eosinophils represent a key cell driving inflammatory processes in diseases such as asthma and eosinophilic esophagitis. The entire process of migration and activation of eosinophils is orchestrated by a myriad of molecules, among which interleukin 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fc511473129a08751568ec55c8c6ac
https://doi.org/10.5334/ejmcm.1
https://doi.org/10.5334/ejmcm.1
Autor:
Patrick Hess, Gunther Schmidt, Katalin Menyhart, Daniel S. Strasser, Alexander Treiber, Claus Müller, Beat Steiner, Daniel Bur, Christopher Kohl, Roberto Bravo, Christoph Binkert, John Gatfield, Stephan Buchmann, Michael Scherz, Boris Mathys, Virginie Sippel, Stefan Abele, Martin Bolli, Oliver Nayler, Thomas Weller, Céline Mangold
Publikováno v:
Journal of Medicinal Chemistry. 53:4198-4211
Sphingosine-1-phosphate (S1P) is a widespread lysophospholipid which displays a wealth of biological effects. Extracellular S1P conveys its activity through five specific G-protein coupled receptors numbered S1P(1) through S1P(5). Agonists of the S1P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888f9c30b8d930c09dc96515275dfc76
https://doi.org/10.1021/jm100181s
https://doi.org/10.1021/jm100181s
Autor:
Daniel Ritz, Alain Chambovey, Alcibiade Athanasiou, Nadia Ekambaram, Daniela Sabato, Mika Gaertner, Daniel S. Strasser, Michel Enderlin, R. Lange, Pierre Wyss, Christopher Kohl, Wolfgang Keck, Maria Boehme, Gaelle Chapoux, Lars Prade, Jean-Luc Specklin, Peter Seiler, Christine Schmitt, Christian Hubschwerlen, Virginie Sippel, Jean-Philippe Surivet, Eser Ilhan, Andreja Knezevic, Hans H. Locher, Daniel Bur
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(21)
A series of 2-amino-[1,8]-naphthyridine-3-carboxamides (ANCs) with potent inhibition of bacterial NAD+-dependent DNA ligases (LigAs) evolved from a 2,4-diaminopteridine derivative discovered by HTS. The design was guided by several highly resolved X-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28ce0a143d3d58078bbea3e3c8a168b
https://pubmed.ncbi.nlm.nih.gov/23006603
https://pubmed.ncbi.nlm.nih.gov/23006603