Ion mobility-mass spectrometry analysis of diarylquinoline diastereomers: Drugs used for tuberculosis treatment

Autor: Laurence Queguiner, Carlos Afonso, Jerome Guillemont, Eric Arnoult, David Speybrouck, Virginie Domalain, Marie Hubert-Roux, Dany Jeanne Dit Fouque

Publikováno v: European Journal of Mass Spectrometry
European Journal of Mass Spectrometry, IM Publications, 2019, 25 (3), pp.291-299. ⟨10.1177/1469066718813226⟩

International audience; Mycobacterium tuberculosis infection results in more than two million deaths per year and is the leading cause of mortality in people infected with HIV. A new structural class of antimycobacterials, the diarylquinolines, has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193463214cb8e11c02132a54dc59c707
https://hal-normandie-univ.archives-ouvertes.fr/hal-02330535

Enantiomeric differentiation of aromatic amino acids using traveling wave ion mobility-mass spectrometry

Autor: Carlos Afonso, Marie Hubert-Roux, Catherine Lange, Virginie Domalain, Jacques Rouden, Vincent Tognetti, Laurent Joubert

Publikováno v: Chemical Science
Chemical Science, The Royal Society of Chemistry, 2014, 5 (8), pp.2041-6520. ⟨10.1039/c4sc00443d⟩

International audience; The present work describes the first differentiation of enantiomers using the coupling of traveling wave ion mobility and mass spectrometry (TWIM-MS). This study was carried out on amino acids, the building blocks of proteins,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1772c5597b09631e76baffb662bdd463
https://hal.archives-ouvertes.fr/hal-01107947

Role of cationization and multimers formation for diastereomers differentiation by ion mobility-mass spectrometry

Autor: Vincent Tognetti, Catherine Lange, Carlos Afonso, Jacques Rouden, Marie Hubert-Roux, Laurent Joubert, Virginie Domalain, Jérôme Baudoux

Publikováno v: Journal of The American Society for Mass Spectrometry
Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2013, 24 (9), pp.1437-1445. ⟨10.1007/s13361-013-0690-1⟩

International audience; Stereochemistry plays an important role in biochemistry, particularly in therapeutic applications. Indeed, enantiomers have different biological activities, which can have important consequences. Many analytical techniques hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf52ab9b370311e75a9a2ac6764710fa
https://hal.archives-ouvertes.fr/hal-00996430