Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Virginia Vega-Warner"'
Autor:
Moritz Lassé, Jamal El Saghir, Celine C. Berthier, Sean Eddy, Matthew Fischer, Sandra D. Laufer, Dominik Kylies, Arvid Hutzfeldt, Léna Lydie Bonin, Bernhard Dumoulin, Rajasree Menon, Virginia Vega-Warner, Felix Eichinger, Fadhl Alakwaa, Damian Fermin, Anja M. Billing, Akihiro Minakawa, Phillip J. McCown, Michael P. Rose, Bradley Godfrey, Elisabeth Meister, Thorsten Wiech, Mercedes Noriega, Maria Chrysopoulou, Paul Brandts, Wenjun Ju, Linda Reinhard, Elion Hoxha, Florian Grahammer, Maja T. Lindenmeyer, Tobias B. Huber, Hartmut Schlüter, Steffen Thiel, Laura H. Mariani, Victor G. Puelles, Fabian Braun, Matthias Kretzler, Fatih Demir, Jennifer L. Harder, Markus M. Rinschen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Kidney organoids are a promising model to study kidney disease, but their use is constrained by limited knowledge of their functional protein expression profile. Here, we define the organoid proteome and transcriptome trajectories over cultu
Externí odkaz:
https://doaj.org/article/39ed8a12de7946c9bcf28c0777cf6607
Autor:
Joseph Wang, Beth Vogt, Sidharth Kumar Sethi, Matthew G. Sampson, Virginia Vega-Warner, Edgar A. Otto, Rupesh Raina
Publikováno v:
Kidney International Reports, Vol 2, Iss 6, Pp 1238-1242 (2017)
Externí odkaz:
https://doaj.org/article/3d08bc58ab65456a84a542ef6f763ef3
Autor:
Sidharth K. Sethi, Nikita Wadhwani, Pranaw Jha, Rajan Duggal, Virginia Vega-Warner, Rupesh Raina, Shyam B. Bansal, Vijay Kher, Matthew G. Sampson, Edgar A. Otto
Publikováno v:
Kidney International Reports, Vol 2, Iss 2, Pp 130-133 (2017)
Externí odkaz:
https://doaj.org/article/9e5e9675be2a476ba650c16d4aa3e664
Autor:
Heon Yung Gee, Carolin E. Sadowski, Pardeep K. Aggarwal, Jonathan D. Porath, Toma A. Yakulov, Markus Schueler, Svjetlana Lovric, Shazia Ashraf, Daniela A. Braun, Jan Halbritter, Humphrey Fang, Rannar Airik, Virginia Vega-Warner, Kyeong Jee Cho, Timothy A. Chan, Luc G. T. Morris, Charles ffrench-Constant, Nicholas Allen, Helen McNeill, Rainer Büscher, Henriette Kyrieleis, Michael Wallot, Ariana Gaspert, Thomas Kistler, David V. Milford, Moin A. Saleem, Wee Teik Keng, Stephen I. Alexander, Rudolph P. Valentini, Christoph Licht, Jun C. Teh, Radovan Bogdanovic, Ania Koziell, Agnieszka Bierzynska, Neveen A. Soliman, Edgar A. Otto, Richard P. Lifton, Lawrence B. Holzman, Nicholas E. S. Sibinga, Gerd Walz, Alda Tufro, Friedhelm Hildebrandt
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Steroid-sensitive nephrotic syndrome (SRNS) can cause CKD and necessitate kidney transplant. Here the authors identify FAT1 mutations by homozygosity mapping and whole-exome sequencing in families with SRNS and provide functional mouse and zebrafish
Externí odkaz:
https://doaj.org/article/28d36207928640028a9a892d5c32fd4f
Autor:
Jameela A. Kari, Sherif M. El-Desoky, Mamdooh Gari, Khalid Malik, Virginia Vega-Warner, Svjetlana Lovric, Detlef Bockenhauer
Publikováno v:
Annals of Saudi Medicine, Vol 33, Iss 6, Pp 533-538 (2013)
BACKGROUND AND OBJECTIVES: Mutations in several genes are known to cause steroid-resistant nephrotic syndome (SRNS), most commonly in NPHS1, NPHS2, and WT1. Our aims were to determine the frequency of mutations in these genes in children with SRNS, t
Externí odkaz:
https://doaj.org/article/d85049ed83464114b746b0d6a0c76b5b
Autor:
Sara L Ma, Virginia Vega-Warner, Christopher Gillies, Matthew G Sampson, Vijay Kher, Sidharth K Sethi, Edgar A Otto
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130729 (2015)
Hypophosphatemic rickets (HR) is a heterogeneous genetic phosphate wasting disorder. The disease is most commonly caused by mutations in the PHEX gene located on the X-chromosome or by mutations in CLCN5, DMP1, ENPP1, FGF23, and SLC34A3. The aims of
Externí odkaz:
https://doaj.org/article/7f8134e8efa441348d26c5525763865f
Autor:
Friedhelm Hildebrandt, Saskia F Heeringa, Franz Rüschendorf, Massimo Attanasio, Gudrun Nürnberg, Christian Becker, Dominik Seelow, Norbert Huebner, Gil Chernin, Christopher N Vlangos, Weibin Zhou, John F O'Toole, Bethan E Hoskins, Matthias T F Wolf, Bernward G Hinkes, Hassan Chaib, Shazia Ashraf, Dominik S Schoeb, Bugsu Ovunc, Susan J Allen, Virginia Vega-Warner, Eric Wise, Heather M Harville, Robert H Lyons, Joseph Washburn, James Macdonald, Peter Nürnberg, Edgar A Otto
Publikováno v:
PLoS Genetics, Vol 5, Iss 1, p e1000353 (2009)
The identification of recessive disease-causing genes by homozygosity mapping is often restricted by lack of suitable consanguineous families. To overcome these limitations, we apply homozygosity mapping to single affected individuals from outbred po
Externí odkaz:
https://doaj.org/article/f7a3369cb3264d36aea1d584e119c0d7
Autor:
Moritz Lassé, Sean Eddy, Jamal El Saghir, Matthew Fischer, Arvid Hutzfeldt, Celine Berthier, Léna Bonin, Bernhard Dumoulin, Rajasree Menon, Virginia Vega-Warner, Felix Eichinger, Fadhl Alakwaa, Damian Fermin, Phillip McCown, Bradley Godfrey, Paul Brandts, Wenjen Ju, Linda Reinhard, Elion Hoxha, Florian Grahammer, Maja Lindenmeyer, Tobias Huber, Hartmut Schlüter, Steffen Thiel, Laura Mariani, Matthias Kretzler, Fatih Demir, Jennifer Harder, Markus Rinschen
Kidney organoids are a promising model to study kidney disease, but use is constrained by limited knowledge of their functional protein expression profile. We aimed to define the organoid proteome and transcriptome trajectories over culture duration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b653fd5d38dc94fc5ea333fa2701cf36
https://doi.org/10.21203/rs.3.rs-2109564/v1
https://doi.org/10.21203/rs.3.rs-2109564/v1
Autor:
Matthew G. Sampson, Martin R. Pollak, Rasheed Gbadegesin, Agnieszka Bierzynska, Liming Wang, Moin A. Saleem, Susan L. Murray, Shane Conlon, Neil K. Fennelly, Moumita Barua, Robert F. Spurney, Brandon M Lane, Gianpiero L. Cavalleri, David N. Howell, Poornima Vijayan, Friedhelm Hildebrandt, Katherine A. Benson, Megan Chryst-Stangl, Guanghong Wu, Shirlee Shril, Peter J. Conlon, Virginia Vega-Warner, Anthony Dorman, Damian Fermin, Brendan Doyle, Mohammad Azfar Qureshi
Publikováno v:
Journal of the American Society of Nephrology. 32:1682-1695
Background Podocyte dysfunction is the main pathologic mechanism driving the development of FSGS and other morphologic types of steroid-resistant nephrotic syndrome (SRNS). Despite significant progress, the genetic causes of most cases of SRNS have y
Autor:
Laura H. Mariani, Sean Eddy, Fadhl M. AlAkwaa, Phillip J. McCown, Jennifer L. Harder, Viji Nair, Felix Eichinger, Sebastian Martini, Adebowale D. Ademola, Vincent Boima, Heather N. Reich, Jamal El Saghir, Bradley Godfrey, Wenjun Ju, Emily C. Tanner, Virginia Vega-Warner, Noel L. Wys, Sharon G. Adler, Gerald B. Appel, Ambarish Athavale, Meredith A. Atkinson, Serena M. Bagnasco, Laura Barisoni, Elizabeth Brown, Daniel C. Cattran, Gaia M. Coppock, Katherine M. Dell, Vimal K. Derebail, Fernando C. Fervenza, Alessia Fornoni, Crystal A. Gadegbeku, Keisha L. Gibson, Laurence A. Greenbaum, Sangeeta R. Hingorani, Michelle A. Hladunewich, Jeffrey B. Hodgin, Marie C. Hogan, Lawrence B. Holzman, J. Ashley Jefferson, Frederick J. Kaskel, Jeffrey B. Kopp, Richard A. Lafayette, Kevin V. Lemley, John C. Lieske, Jen-Jar Lin, Rajarasee Menon, Kevin E. Meyers, Patrick H. Nachman, Cynthia C. Nast, Michelle M. O’Shaughnessy, Edgar A. Otto, Kimberly J. Reidy, Kamalanathan K. Sambandam, John R. Sedor, Christine B. Sethna, Pamela Singer, Tarak Srivastava, Cheryl L. Tran, Katherine R. Tuttle, Suzanne M. Vento, Chia-shi Wang, Akinlolu O. Ojo, Dwomoa Adu, Debbie S. Gipson, Howard Trachtman, Matthias Kretzler
Publikováno v:
Kidney international.
The diagnosis of nephrotic syndrome relies on clinical presentation and descriptive patterns of injury on kidney biopsies, but not specific to underlying pathobiology. Consequently, there are variable rates of progression and response to therapy with