Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Virginia Smith Shapiro"'
Autor:
Drew Wilfahrt, Rachael L Philips, Jyoti Lama, Monika Kizerwetter, Michael Jeremy Shapiro, Shaylene A McCue, Madeleine M Kennedy, Matthew J Rajcula, Hu Zeng, Virginia Smith Shapiro
Publikováno v:
eLife, Vol 10 (2021)
After antigenic activation, quiescent naive CD4+ T cells alter their metabolism to proliferate. This metabolic shift increases production of nucleotides, amino acids, fatty acids, and sterols. Here, we show that histone deacetylase 3 (HDAC3) is criti
Externí odkaz:
https://doaj.org/article/4663fbf5394c4aa88ceec8a8cec5a37d
Autor:
Michael Jonathan Lehrke, Michael Jeremy Shapiro, Matthew J Rajcula, Madeleine M Kennedy, Shaylene A McCue, Kay L Medina, Virginia Smith Shapiro
Publikováno v:
eLife, Vol 10 (2021)
Iron-sulfur (Fe-S) clusters are cofactors essential for the activity of numerous enzymes including DNA polymerases, helicases, and glycosylases. They are synthesized in the mitochondria as Fe-S intermediates and are exported to the cytoplasm for matu
Externí odkaz:
https://doaj.org/article/b26e13f1acd846d4bac1d67398df6ccb
Autor:
Puspa Thapa, Bryce Manso, Ji Young Chung, Sinibaldo Romera Arocha, Hai-Hui Xue, Derek B. Sant’ Angelo, Virginia Smith Shapiro
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract iNKT cells are a unique lineage of T cells that recognize glycolipid presented by CD1d. In the thymus, they differentiate into iNKT1, iNKT2 and iNKT17 effector subsets, characterized by preferential expression of Tbet, Gata3 and ROR-γt and
Externí odkaz:
https://doaj.org/article/a955fde430764952a7afc41f1001ca19
Autor:
Puspa Thapa, Sinibaldo Romero Arocha, Ji Young Chung, Derek B. Sant’Angelo, Virginia Smith Shapiro
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract NKT cells are a distinct subset that have developmental requirements that often differ from conventional T cells. Here, we show that NKT-specific deletion of Hdac3 results in a severe reduction in the number of iNKT cells, particularly of NK
Externí odkaz:
https://doaj.org/article/bb0b26a9f24f4d3983eb28ce34699aa4
Autor:
Michael Jeremy Shapiro, Joshua Anderson, Michael Jonathan Lehrke, Meibo Chen, Molly Nelson Holte, Virginia Smith Shapiro
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
NKAP is a multi-functional nuclear protein that has been shown to be essential for hematopoiesis. Deletion of NKAP in hematopoietic stem cells (HSCs) was previously found to result in rapid lethality and hematopoietic failure. NKAP deficient cells al
Externí odkaz:
https://doaj.org/article/7de0739ec1434095b7b29839cef768b1
Autor:
Rachael Laura Philips, Jeong-Heon Lee, Krutika Gaonkar, Pritha Chanana, Ji Young Chung, Sinibaldo R Romero Arocha, Aaron Schwab, Tamas Ordog, Virginia Smith Shapiro
Publikováno v:
eLife, Vol 8 (2019)
CD4 and CD8 T cells are vital components of the immune system. We found that histone deacetylase 3 (HDAC3) is critical for the development of CD4 T cells, as HDAC3-deficient DP thymocytes generate only CD8SP thymocytes in mice. In the absence of HDAC
Externí odkaz:
https://doaj.org/article/4f974d4050784a4c9ce2da8e6839f697
Autor:
Kay L Medina, Sarah N Tangen, Lauren M Seaburg, Puspa Thapa, Kimberly A Gwin, Virginia Smith Shapiro
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78408 (2013)
B-cell-biased lymphoid progenitors (BLPs) and Pre-pro B cells lie at a critical juncture between B cell specification and commitment. However, both of these populations are heterogenous, which hampers investigation into the molecular changes that occ
Externí odkaz:
https://doaj.org/article/c6c441f284724124a84b17f84670151e
Autor:
Virginia Smith Shapiro, Haidong Dong, Khashayarsha Khazaie, Xin Liu, Shaylene McCue, Matthew Rajcula, Michael J. Shapiro, Sydney B. Crotts, David J. Friedman
Many tumors exhibit increased incorporation of sialic acids into cell-surface glycans, which impact the tumor microenvironment. Sialic acid immunoglobulin-like lectins (Siglec) are receptors that recognize sialic acids and modulate immune responses,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812fed0ee91f24fd254196cea5b5055e
https://doi.org/10.1158/2326-6066.c.6550544
https://doi.org/10.1158/2326-6066.c.6550544
Autor:
Virginia Smith Shapiro, Haidong Dong, Khashayarsha Khazaie, Xin Liu, Shaylene McCue, Matthew Rajcula, Michael J. Shapiro, Sydney B. Crotts, David J. Friedman
Supplementary Tables S1-S2 and Supplementary Figures S1-S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d97fe1888db2bdca5747aa72edc7411
https://doi.org/10.1158/2326-6066.22544138
https://doi.org/10.1158/2326-6066.22544138
Autor:
David J. Friedman, Monika Kizerwetter, Paul Belmonte, Matthew Rajcula, Keith Theodore, Hyun Se Kim Lee, Michael J. Shapiro, Haidong Dong, Virginia Smith Shapiro
Publikováno v:
The Journal of Immunology. 208:1845-1850
Inhibitory receptors have a critical role in the regulation of immunity. Siglecs are a family of primarily inhibitory receptors expressed by immune cells that recognize specific sialic acid modifications on cell surface glycans. Many tumors have incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::804592450ef1595bd2c2ff048786be02
https://doi.org/10.4049/jimmunol.2101165
https://doi.org/10.4049/jimmunol.2101165