Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Virginia Shapiro"'
Autor:
Brandon Lee Maniaci, David Friedman, Sydney Crotts, Matthew Rajcula, Keith Theodore, Hyun Se Kim Lee, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 208:61.02-61.02
The lifetime risk for colorectal cancer in the United States is approximately 4%. Individuals with Inflammatory Bowel Disease, including Ulcerative Colitis and Crohn’s Disease, have a substantially increased risk of developing colorectal cancer. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bf11856bb934a9d4d1954d95a604a8b
https://doi.org/10.4049/jimmunol.208.supp.61.02
https://doi.org/10.4049/jimmunol.208.supp.61.02
Autor:
Sydney B Crotts, Regina Antonetti, Michael J Shapiro, Matthew Rajcula, Keith Theodore, Hyun Se Kim Lee, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 208:103.09-103.09
Inflammatory bowel disorders (IBD) including ulcerative colitis (UC) and Crohn’s disease (CD) affect between 1–3 million people in the United States with prevalence on the rise. Patients present with symptoms including diarrhea, abdominal cramps,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cf45bb4193a565617774b28d2c9debf
https://doi.org/10.4049/jimmunol.208.supp.103.09
https://doi.org/10.4049/jimmunol.208.supp.103.09
Autor:
Justin Choe, Paul Belmonte, Matthew Rajcula, Keith Theodore, Hyun Se Kim Lee, Michael J Shapiro, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 208:174.09-174.09
In this study, we harnessed immunomodulatory Siglec-sialic acid interactions to mitigate autoimmune rejection of beta cells in Type 1 Diabetes (T1D). Mice engineered to express the sialyltransferase ST8Sia6 in beta cells (βST mice) were backcrossed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f2d5e54b8799e5dbed5e34097a21f16
https://doi.org/10.4049/jimmunol.208.supp.174.09
https://doi.org/10.4049/jimmunol.208.supp.174.09
Autor:
Justin Choe, Paul Belmonte, Matthew Rajcula, Shaylene McCue, Michael J Shapiro, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 206:18.12-18.12
Cell surface hypersialylation is used by malignant cells as a survival mechanism, leveraging interactions with inhibitory Siglec receptors to dampen immune rejection. In this study, we harnessed this mechanism to prevent autoimmune rejection of beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::472ccfc9d91e9c14bc6b313c270202c7
https://doi.org/10.4049/jimmunol.206.supp.18.12
https://doi.org/10.4049/jimmunol.206.supp.18.12
Autor:
Xian Zhou, Xingxing Zhu, Chaofan Li, Virginia Shapiro, Taro Hitosugi, Jie Sun, John A. Copland, Hu Zeng
Publikováno v:
The Journal of Immunology. 206:63.01-63.01
Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The role of different FA species, and their impacts on humoral immunity remains poorly understood. Here we report that proliferating B cells require monounsat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3cb011072a936263af360cae155f56b
https://doi.org/10.4049/jimmunol.206.supp.63.01
https://doi.org/10.4049/jimmunol.206.supp.63.01
Autor:
Bibo Zhu, Yue Wu, Su Huang, Ruixuan Zhang, Chaofan Li, In Su Cheon, Min Wang, Xian Zhou, Quynh Nguyen, Hu Zeng, M. Mark Taketo, Matthias Mack, Virginia Shapiro, Xiaobo Zhou, Ananda Goldrath, Mark H Kaplan, Jie Sun
Publikováno v:
The Journal of Immunology. 204:69.6-69.6
Fetal-derived tissue-resident macrophages exhibit stem cell-like features of self-renewal in adulthood to maintain macrophage population during homeostasis and/or various insults. However, little is known about the cellular and molecular mechanisms m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c33eed8aaf9547af0875ba5bc6b61fbc
https://doi.org/10.4049/jimmunol.204.supp.69.6
https://doi.org/10.4049/jimmunol.204.supp.69.6
Autor:
Paul Belmonte, Fan-Chi Hsu, Barsha Dash, Ji Young Chung, Sinibaldo Romero Arocha, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 198:60.17-60.17
T cells require additional developmental steps after positive selection before they are functionally competent and can enter the long-lived peripheral T cell pool. During maturation, T cells gain the ability to produce cytokines upon stimulation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2c5ea9c239514980e071198286837ec
https://doi.org/10.4049/jimmunol.198.supp.60.17
https://doi.org/10.4049/jimmunol.198.supp.60.17
Autor:
Rachael Laura Philips, Jeong-Heon Lee, Krutika Gaonkar, Ji Young Chung, Sinibaldo Romero Arocha, Tamas Ordog, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 198:60.4-60.4
MHC-restricted CD4 and CD8 T cells are vital components of the immune system. The decision to generate CD4 or CD8 T cells occurs in the thymus. After positive selection, intermediate thymocytes downregulate CD8 to test coreceptor specificity. Thymocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85be1753d810e7caacf27f091922872d
https://doi.org/10.4049/jimmunol.198.supp.60.4
https://doi.org/10.4049/jimmunol.198.supp.60.4
Publikováno v:
The Journal of Immunology. 196:121.5-121.5
NKAP is a transcriptional repressor required at various stages of conventional αβ T cell development. Here, we asked if NKAP is also required in regulatory T cells. To answer this, we created Foxp3-YFP-cre NKAP conditional knock-out (cKO) mice in w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bf08e001f04e99feac149e9ff27949b
https://doi.org/10.4049/jimmunol.196.supp.121.5
https://doi.org/10.4049/jimmunol.196.supp.121.5
Autor:
Rachael Philips, Meibo Chen, Doug McWilliams, Paul Belmonte, Megan Constans, Scott Hiebert, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 194:51.6-51.6
In order to generate functional peripheral T cells, proper gene regulation during T cell development is critical. Development involves both the activation and repression of genes as cells progress through each developmental checkpoint. Histone acetyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02a3befad1a141847afeef1da23dc898
https://doi.org/10.4049/jimmunol.194.supp.51.6
https://doi.org/10.4049/jimmunol.194.supp.51.6