Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation

Autor: Virginia S. Lioy, Jean-Noël Lorenzi, Soumaya Najah, Thibault Poinsignon, Hervé Leh, Corinne Saulnier, Bertrand Aigle, Sylvie Lautru, Annabelle Thibessard, Olivier Lespinet, Pierre Leblond, Yan Jaszczyszyn, Kevin Gorrichon, Nelle Varoquaux, Ivan Junier, Frédéric Boccard, Jean-Luc Pernodet, Stéphanie Bury-Moné

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Streptomyces bacteria have a linear chromosome, with core genes located in the central region and gene clusters for specialized metabolite biosynthesis found in the ‘arms’. Here, Lioy et al. show that such chromosome structure correlates with gen

Externí odkaz: https://doaj.org/article/69ebdcca68044d26ae4c0c82ce1b8f3e

Toxin ζ Triggers a Survival Response to Cope with Stress and Persistence

Autor: María Moreno-del Álamo, Mariangela Tabone, Virginia S. Lioy, Juan C. Alonso

Publikováno v: Frontiers in Microbiology, Vol 8 (2017)

Bacteria have evolved complex regulatory controls in response to various environmental stresses. Protein toxins of the ζ superfamily, found in prominent human pathogens, are broadly distributed in nature. We show that ζ is a uridine diphosphate-N-a

Externí odkaz: https://doaj.org/article/efa72307c03848159ef0219c656ba51d

Ribosomal RNA operons define a central functional compartment in the Streptomyces chromosome

Autor: Jean-Noël Lorenzi, Annabelle Thibessard, Virginia S. Lioy, Frédéric Boccard, Pierre Leblond, Jean-Luc Pernodet, Stéphanie Bury-Moné

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2022, 50 (20), pp.11654-11669. ⟨10.1093/nar/gkac1076⟩

Streptomyces are prolific producers of specialized metabolites with applications in medicine and agriculture. These bacteria possess a large linear chromosome genetically compartmentalized: core genes are grouped in the central part, while terminal r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbd5993685c68686414830f3ac5386b
https://pubmed.ncbi.nlm.nih.gov/36408918

Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation

Autor: Nelle Varoquaux, Bertrand Aigle, Sylvie Lautru, Jean-Noël Lorenzi, Corinne Saulnier, Jean-Luc Pernodet, Ivan Junier, Virginia S. Lioy, Yan Jaszczyszyn, Kevin Gorrichon, Hervé Leh, Frédéric Boccard, Thibault Poinsignon, Soumaya Najah, Pierre Leblond, Stéphanie Bury-Moné, Annabelle Thibessard, Olivier Lespinet

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12, pp.5221. ⟨10.1038/s41467-021-25462-1⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-25462-1⟩
BioRxiv
Nature Communications, 2021, 12, pp.5221. ⟨10.1038/s41467-021-25462-1⟩
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Bacteria of the genus Streptomyces are prolific producers of specialized metabolites, including antibiotics. The linear chromosome includes a central region harboring core genes, as well as extremities enriched in specialized metabolite biosynthetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277c6baa0aecb3b4d45b4196a94f7624
https://doi.org/10.21203/rs.3.rs-145840/v1

Fine-tuning of the Smc flux facilitates chromosome organization in B. subtilis

Autor: Anna Anchimiuk, Frédéric Boccard, Anita Minnen, Stephan Gruber, Virginia S. Lioy

SMC complexes are widely conserved ATP-powered loop extrusion motors indispensable for the faithful segregation of chromosomes during cell division. How SMC complexes translocate along DNA for loop extrusion and what happens when two complexes meet o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86c28a5adf716a5974ec7d52a3f28155
https://doi.org/10.1101/2020.12.04.411900