Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Virginia Plá"'
Autor:
Virginia Plá, Styliani Bitsika, Michael J. Giannetto, Antonio Ladrón-de-Guevara, Daniel Gahn-Martinez, Yuki Mori, Maiken Nedergaard, Kjeld Møllgård
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-10 (2024)
Abstract Histological studies have for decades documented that each of the classical meningeal membranes contains multiple fibroblast layers with distinct cellular morphology. Particularly, the sublayers of the arachnoid membranes have received atten
Externí odkaz:
https://doaj.org/article/472c74593c8e4f0eba1befe3b63d9819
Autor:
Virginia Plá, Styliani Bitsika, Michael J Giannetto, Antonio Ladron-de-Guevara, Daniel Gahn-Martinez, Yuki Mori, Maiken Nedergaard, Kjeld Møllgård
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-18 (2023)
Abstract Traditionally, the meninges are described as 3 distinct layers, dura, arachnoid and pia. Yet, the classification of the connective meningeal membranes surrounding the brain is based on postmortem macroscopic examination. Ultrastructural and
Externí odkaz:
https://doaj.org/article/af3f7078fdc547869621fad3e927cd40
Autor:
Virginia Plá, Styliani Bitsika, Michael J. Giannetto, Antonio Ladron-de-Guevara, Daniel Gahn-Martinez, Yuki Mori, Maiken Nedergaard, Kjeld Møllgård
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/498edd48fbf84374b6d26ea5b23a3372
Autor:
Xiaowei Wang, Christine Delle, Weiguo Peng, Virginia Plá, Michael Giannetto, Peter Kusk, Björn Sigurdsson, Shinya Sakurai, Amanda Sweeney, Qian Sun, Ting Du, Richard T. Libby, Maiken Nedergaard
Publikováno v:
Neurobiology of Disease, Vol 188, Iss , Pp 106322- (2023)
The ocular glymphatic system supports bidirectional fluid transport along the optic nerve, thereby removes metabolic wastes including amyloid-β. To better understand this biological process, we examined the distributions of intravitreally and intrac
Externí odkaz:
https://doaj.org/article/106caf26e0484bc3b434466aa008f99e
Autor:
Neus Barranco, Virginia Plá, Daniel Alcolea, Irene Sánchez-Domínguez, Reiner Fischer-Colbrie, Isidro Ferrer, Alberto Lleó, Fernando Aguado
Publikováno v:
Translational Neurodegeneration, Vol 10, Iss 1, Pp 1-15 (2021)
Abstract Background New fluid biomarkers for Alzheimer's disease (AD) that reveal synaptic and neural network dysfunctions are needed for clinical practice and therapeutic trial design. Dense core vesicle (DCV) cargos are promising cerebrospinal flui
Externí odkaz:
https://doaj.org/article/b1799d7ef6e440089c5948eebb165e0c
Autor:
Lauren M. Hablitz, Virginia Plá, Michael Giannetto, Hanna S. Vinitsky, Frederik Filip Stæger, Tanner Metcalfe, Rebecca Nguyen, Abdellatif Benrais, Maiken Nedergaard
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Glymphatic function is increased during the rest phase while more cerebrospinal fluid (CSF) drains directly to the lymphatic system during the active phase. The water channel aquaporin-4 supports these endogenous, circadian rhythms in CSF distributio
Externí odkaz:
https://doaj.org/article/52b023d7976d45dea43058d42e720d90
Autor:
Humberto Mestre, Lauren M Hablitz, Anna LR Xavier, Weixi Feng, Wenyan Zou, Tinglin Pu, Hiromu Monai, Giridhar Murlidharan, Ruth M Castellanos Rivera, Matthew J Simon, Martin M Pike, Virginia Plá, Ting Du, Benjamin T Kress, Xiaowen Wang, Benjamin A Plog, Alexander S Thrane, Iben Lundgaard, Yoichiro Abe, Masato Yasui, John H Thomas, Ming Xiao, Hajime Hirase, Aravind Asokan, Jeffrey J Iliff, Maiken Nedergaard
Publikováno v:
eLife, Vol 7 (2018)
The glymphatic system is a brain-wide clearance pathway; its impairment contributes to the accumulation of amyloid-β. Influx of cerebrospinal fluid (CSF) depends upon the expression and perivascular localization of the astroglial water channel aquap
Externí odkaz:
https://doaj.org/article/9fe3ab146a0849b2a74eb8c9bba7a959
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Regulated secretion of neuropeptides and neurotrophic factors critically modulates function and plasticity of synapses and circuitries. It is believed that rising amyloid-β (Aβ) concentrations, synaptic dysfunction and network disorganization under
Externí odkaz:
https://doaj.org/article/f5ffc90697964d9a83f82d25dd4f7c74
Autor:
Kjeld Møllgård, Felix R. M. Beinlich, Peter Kusk, Leo M. Miyakoshi, Christine Delle, Virginia Plá, Natalie L. Hauglund, Tina Esmail, Martin K. Rasmussen, Ryszard S. Gomolka, Yuki Mori, Maiken Nedergaard
Publikováno v:
Science. 379:84-88
The central nervous system is lined by meninges, classically known as dura, arachnoid, and pia mater. We show the existence of a fourth meningeal layer that compartmentalizes the subarachnoid space in the mouse and human brain, designated the subarac
Autor:
Virginia Plá, Maiken Nedergaard
Publikováno v:
Nature Cardiovascular Research. 1:1114-1115