Zobrazeno 1 - 10
of 1 056
pro vyhledávání: '"Virginia M.-Y. Lee"'
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/d0a1f7879a264df9b8352ca543b913dc
Autor:
Noah Lubben, Julia K. Brynildsen, Connor M. Webb, Howard L. Li, Cheryl E. G. Leyns, Lakshmi Changolkar, Bin Zhang, Emily S. Meymand, Mia O’Reilly, Zach Madaj, Daniella DeWeerd, Matthew J. Fell, Virginia M. Y. Lee, Dani S. Bassett, Michael X. Henderson
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-20 (2024)
Abstract Background Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). These mutations elevate the LRRK2 kinase activity, making LRRK2 kinase inhibitors an attractive therapeutic. LRRK2
Externí odkaz:
https://doaj.org/article/1f84f0e37fc14d51a4c531d8dca9e20e
Autor:
Norihito Uemura, Nicholas P. Marotta, Jahan Ara, Emily S. Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C. Luk, John Q. Trojanowski, Virginia M.-Y. Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Extraction of α-Synuclein (αSyn) aggregates from Lewy body disease (LBD) brains has been widely described yet templated fibrillization of LB-αSyn often fails to propagate its structural and functional properties. We recently demonstrated
Externí odkaz:
https://doaj.org/article/c249b84834e1414cabb7db6ae3c525cf
Autor:
Cheryl E. G. Leyns, Alice Prigent, Brenna Beezhold, Lihang Yao, Nathan G. Hatcher, Peining Tao, John Kang, EunRan Suh, Vivianna M. Van Deerlin, John Q. Trojanowski, Virginia M. Y. Lee, Matthew E. Kennedy, Matthew J. Fell, Michael X. Henderson
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases characterized by the accumulation of misfolded α-synuclein in the form of Lewy pathology. While most cases are sporadic, there are rar
Externí odkaz:
https://doaj.org/article/ffdac8823595475f8729dc4c771b2777
Autor:
Tariq Afroz, Elodie Chevalier, Mickael Audrain, Christopher Dumayne, Tamar Ziehm, Roger Moser, Anne-Laure Egesipe, Lorène Mottier, Monisha Ratnam, Manuela Neumann, Daniel Havas, Romain Ollier, Kasia Piorkowska, Mayank Chauhan, Alberto B. Silva, Samjhana Thapa, Jan Stöhr, Andrej Bavdek, Valerie Eligert, Oskar Adolfsson, Peter T. Nelson, Sílvia Porta, Virginia M.-Y. Lee, Andrea Pfeifer, Marie Kosco-Vilbois, Tamara Seredenina
Publikováno v:
Neurobiology of Disease, Vol 179, Iss , Pp 106050- (2023)
Effective therapies are urgently needed to safely target TDP-43 pathology as it is closely associated with the onset and development of devastating diseases such as frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) and amyotrophic la
Externí odkaz:
https://doaj.org/article/0ae8a176004d45538a54e3b880d79375
Autor:
Aurelio J. Dregni, Pu Duan, Hong Xu, Lakshmi Changolkar, Nadia El Mammeri, Virginia M.-Y. Lee, Mei Hong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The tau protein in Alzheimer’s disease contains two isoforms. Using solid-state NMR and seeded growth of isotopically labeled tau, here the authors determined that the two isoforms mix fluently on the molecular level to propagate the AD tau structu
Externí odkaz:
https://doaj.org/article/9efac7b1629744018fcd3391bfe6243e
Autor:
Seong Kwon Hur, Mandana Hunter, Myrna A. Dominique, Madona Farag, Dejania Cotton-Samuel, Tahiyana Khan, John Q. Trojanowski, Krista J. Spiller, Virginia M.-Y. Lee
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-16 (2022)
Abstract In the intermediate stages of amyotrophic lateral sclerosis (ALS), surviving motor neurons (MNs) that show intrinsic resistance to TDP-43 proteinopathy can partially compensate for the loss of their more disease-susceptible counterparts. Elu
Externí odkaz:
https://doaj.org/article/1b3b0b964de041b99491d6bba9c751fc
Autor:
Courtney A. Marshall, Jennifer D. McBride, Lakshmi Changolkar, Dawn M. Riddle, John Q. Trojanowski, Virginia M.-Y. Lee
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder that exhibits pathological changes in both tau and synaptic function. AD patients display increases in hyperphosphorylated tau and synaptic activity. Previous studies have individual
Externí odkaz:
https://doaj.org/article/6701d14350d140dbb6bdce7263329ac0
Autor:
Nicholas P. Marotta, Jahan Ara, Norihito Uemura, Marshall G. Lougee, Emily S. Meymand, Bin Zhang, E. James Petersson, John Q. Trojanowski, Virginia M.-Y. Lee
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract Lewy bodies (LBs) are complex, intracellular inclusions that are common pathological features of many neurodegenerative diseases. They consist largely of aggregated forms of the protein alpha-Synuclein (α-Syn), which misfolds to give rise t
Externí odkaz:
https://doaj.org/article/bf7a534148ef4b5692dfe56fe3d96872
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Several studies investigating the pathogenesis of Alzheimer’s disease have identified various interdependent constituents contributing to the exacerbation of the disease, including Aβ plaque formation, tau protein hyperphosphorylation, neurofibril
Externí odkaz:
https://doaj.org/article/6d317899ec664ddea3f0a3b1c1ed3840