Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Virginia M Howick"'
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010346 (2022)
Early diverging lineages such as trypanosomes can provide clues to the evolution of sexual reproduction in eukaryotes. In Trypanosoma brucei, the pathogen that causes Human African Trypanosomiasis, sexual reproduction occurs in the salivary glands of
Externí odkaz:
https://doaj.org/article/05b3fd978cb540eda1ae2920ea88448c
Autor:
Eliana Real, Virginia M. Howick, Farah A. Dahalan, Kathrin Witmer, Juliana Cudini, Clare Andradi-Brown, Joshua Blight, Mira S. Davidson, Sunil Kumar Dogga, Adam J. Reid, Jake Baum, Mara K. N. Lawniczak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Here the authors use single-cell RNA-seq to profile the transmission stages of the human malaria parasite Plasmodium falciparum as it progresses through the Anopheles mosquito. They highlight unique patterns of gene usage throughout this development
Externí odkaz:
https://doaj.org/article/d794f8b7a61a40a4b465c503752b3e54
Autor:
Kathrin Witmer, Farah Aida Dahalan, Tom Metcalf, Arthur M. Talman, Virginia M. Howick, Mara K. N. Lawniczak
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
The crossing of the mosquito midgut epithelium by the malaria parasite motile ookinete form represents the most extreme population bottleneck in the parasite life cycle and is a prime target for transmission blocking strategies. However, we have litt
Externí odkaz:
https://doaj.org/article/88890f7ac9334ac889ae2f04375cb72c
Uptake of Plasmodium falciparum Gametocytes During Mosquito Bloodmeal by Direct and Membrane Feeding
Autor:
Arthur M. Talman, Dinkorma T. D. Ouologuem, Katie Love, Virginia M. Howick, Charles Mulamba, Aboubecrin Haidara, Niawanlou Dara, Daman Sylla, Adama Sacko, Mamadou M. Coulibaly, Francois Dao, Cheick P. O. Sangare, Abdoulaye Djimde, Mara K. N. Lawniczak
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Plasmodium falciparum remains one of the leading causes of child mortality, and nearly half of the world’s population is at risk of contracting malaria. While pathogenesis results from replication of asexual forms in human red blood cells, it is th
Externí odkaz:
https://doaj.org/article/5d33fd19840b4845a41408d7fcc6f885
Autor:
Lori Peacock, Virginia M. Howick, Christopher Kay, Mara K. N. Lawniczak, Wendy Gibson, Clare Collett
Early diverging lineages such as trypanosomes can provide clues to the evolution of sexual reproduction in eukaryotes. In Trypanosoma brucei, the pathogen that causes Human African Trypanosomiasis, sexual reproduction occurs in the salivary glands of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c43d43fcca09676faa0813dbfae2cd1
https://doi.org/10.1101/2021.10.13.463681
https://doi.org/10.1101/2021.10.13.463681
Autor:
Virginia M. Howick, Jake Baum, Adam J. Reid, Clare Andradi-Brown, Juliana Cudini, Mara K. N. Lawniczak, Eliana Real, Mira S. Davidson, Kathrin Witmer, Farah A. Dahalan, Sunil Kumar Dogga, Joshua Blight
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Malaria parasites have a complex life cycle featuring diverse developmental strategies, each uniquely adapted to navigate specific host environments. Here we use single-cell transcriptomics to illuminate gene usage across the transmission cycle of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7d49063d59656c4ae5794ba8204e54
https://eprints.gla.ac.uk/242772/1/242772.pdf
https://eprints.gla.ac.uk/242772/1/242772.pdf
Autor:
Nicholas J. White, Mara K. N. Lawniczak, Darunee Chiwcharoen, Kathrin Witmer, Arjen M. Dondorp, Kesinee Chotivanich, Oliver J Watson, Virginia M. Howick, Jake Baum, Lucy C Okell, Richard D. Pearson, Michael J. Delves, Andrea Ruecker, Farah A. Dahalan, Boodtee Sornboon, Sasithon Pukrittayakamee, Sabrina Yahiya, Ursula Straschil
Publikováno v:
Antimicrobial Agents and Chemotherapy
Antimicrobial agents and chemotherapy, 65(1):e00898-20. American Society for Microbiology
Antimicrobial agents and chemotherapy, 65(1):e00898-20. American Society for Microbiology
Resistance to artemisinin-based combination therapy (ACT) in the Plasmodium falciparum parasite is threatening to reverse recent gains in reducing global deaths from malaria. While resistance manifests as delayed parasite clearance in patients, the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222babf9a1a4a841550f7ebef07a8dea
https://doi.org/10.1128/aac.00898-20
https://doi.org/10.1128/aac.00898-20
Uptake of Plasmodium falciparum Gametocytes During Mosquito Bloodmeal by Direct and Membrane Feeding
Autor:
Virginia M. Howick, François Dao, Mamadou M. Coulibaly, Katie Love, Daman Sylla, Adama Sacko, Charles Mulamba, Aboubecrin Sedhigh Haidara, Dinkorma T. Ouologuem, Arthur M. Talman, Niawanlou Dara, Cheick Papa Oumar Sangare, Mara K. N. Lawniczak, Abdoulaye Djimde
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Plasmodium falciparum remains one of the leading causes of child mortality, and nearly half of the world’s population is at risk of contracting malaria. While pathogenesis results from replication of asexual forms in human red blood cells, it is th
Artemisinin-resistant malaria parasites show enhanced transmission to mosquitoes under drug pressure
Autor:
Lawniczak Mkn., Kesinee Chotivanich, Arjen M. Dondorp, Oliver J Watson, S Pukrittayakamee, Ursula Straschil, Michael J. Delves, Kathrin Witmer, D Chiwcharoen, Farah A. Dahalan, Virginia M. Howick, Sabrina Yahiya, B Sornboon, Richard D. Pearson, Nicholas J. White, Jake Baum, Lucy C Okell, Andrea Ruecker
Resistance to artemisinin combination therapy (ACT) in the Plasmodium falciparum parasite is threatening to reverse recent gains in reducing global deaths from malaria. Whilst resistance manifests as delayed asexual parasite clearance in patients fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ff2e4d04fe0f9cfbea08ede84da563
Autor:
Brian P. Lazzaro, Virginia M. Howick
Publikováno v:
Molecular Ecology. 26:1533-1546
Defence against pathogenic infection can take two forms: resistance and tolerance. Resistance is the ability of the host to limit a pathogen burden, whereas tolerance is the ability to limit the negative consequences of infection at a given level of