Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Virginia L. Smith-Swintosky"'
Autor:
Susan D. Craddock, Russell E. Rydel, Virginia L. Smith-Swintosky, L. Creed Pettigrew, Mark P. Mattson, Alan R. Culwell
Publikováno v:
Journal of Neurochemistry. 63:781-784
The beta-amyloid precursor protein (beta APP) is the source of the amyloid beta-peptide that accumulates in the brain in Alzheimer's disease. A major processing pathway for beta APP involves an enzymatic cleavage within the amyloid beta-peptide seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1a8205dc25a4f2ce06b03679ac2dcc
https://doi.org/10.1046/j.1471-4159.1994.63020781.x
https://doi.org/10.1046/j.1471-4159.1994.63020781.x
Autor:
John T. Slevin, Annadora J. Bruce, Mark P. Mattson, Russell W. Brown, Mona Alcala, Philipp J. Kraemer, Nicole McCants, Andrew Maki, Yadong Goodman, Virginia L. Smith-Swintosky
Publikováno v:
Experimental Neurology. 141:287-296
Studies of human patients with temporal lobe epilepsy and animal models of epilepsy have established relationships between seizures, excitotoxic hippocampal damage, and memory impairment. We report that bacterial alkaloids, recently shown to mimic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388568525094003dcdddd93e7f3dcc2d
https://doi.org/10.1006/exnr.1996.0163
https://doi.org/10.1006/exnr.1996.0163
Autor:
Mark P. Mattson, Virginia L. Smith-Swintosky, Robert M. Sapolsky, Sheila M. Brooke, Chris Phares, L. Creed Pettigrew, Susan D. Craddock
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 16:585-598
Increasing evidence indicates that glucocorticoids (GCs), produced in response to physical/emotional stressors, can exacerbate brain damage resulting from cerebral ischemia and severe seizure activity. However, much of the supporting evidence has com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84614f650879571e6813331bf71e5b71
https://doi.org/10.1097/00004647-199607000-00008
https://doi.org/10.1097/00004647-199607000-00008
Publikováno v:
The Journal of Neuroscience. 15:5840-5850
Protease nexin-I (PN-1) is a 44 kDa serine proteinase inhibitor that rapidly inhibits thrombin by forming SDS stable complexes with serine at the catalytic site of the protease. Levels of both PN-1 and thrombin are increased in the brain in response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f63e673c6fd77121ebbfab8b786efb
https://doi.org/10.1523/jneurosci.15-08-05840.1995
https://doi.org/10.1523/jneurosci.15-08-05840.1995
Publikováno v:
Annals of the New York Academy of Sciences. 695:158-164
The suspected involvement of the beta-amyloid precursor protein (beta APP) in the etiology of Alzheimer's disease (AD) has been strengthened by recent genetic evidence, but pursuit of the mechanisms involved will initially require basic cell biology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1af2d6ec2a8a65ec4ce7761ef32c401
https://doi.org/10.1111/j.1749-6632.1993.tb23045.x
https://doi.org/10.1111/j.1749-6632.1993.tb23045.x
Publikováno v:
Seminars in Neuroscience. 5:295-307
Several conventional and novel growth factors (GFs) canprotect neurons against an array of insults including excitotoxins, hypoglycemia, hypoxia, free radicals and β-amyloid peptide. In tissue culture experiments basic fibroblast growth factor (bFGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bd8888b19cfafd8791fdd4d715c66de
https://doi.org/10.1016/s1044-5765(05)80035-1
https://doi.org/10.1016/s1044-5765(05)80035-1
Publikováno v:
Annals of the New York Academy of Sciences. 679:1-21
Several cellular signaling systems have been implicated in the neuronal death that occurs both in development ("natural" cell death) or in pathological conditions such as stroke and Alzheimer's disease (AD). Here we consider the possibility that neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274063559a0ae05f2c6cc33936e28366
https://doi.org/10.1111/j.1749-6632.1993.tb18285.x
https://doi.org/10.1111/j.1749-6632.1993.tb18285.x
Autor:
Virginia L. Smith-Swintosky
Publikováno v:
Neuroprotective Signal Transduction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c5b44a5617254ee6973fbab7d334e41
https://doi.org/10.1385/0-89603-473-9:243
https://doi.org/10.1385/0-89603-473-9:243
Autor:
Virginia L. Smith-Swintosky, Catherine T. Cheo‐Isaacs, Patricia Andrade-Gordon, Andrew L. Darrow, Michael R. D'Andrea, Rosemary J. Santulli
Publikováno v:
Journal of neurochemistry. 69(5)
Protease-activated receptor-2 (PAR-2) is a seven-transmembrane G protein-coupled receptor that possesses a structure and activation mechanism similar to those of the thrombin receptor. It is activated by low concentrations of trypsin (300 pM) and a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8769f63cb9bf1c423746b75324835845
https://pubmed.ncbi.nlm.nih.gov/9349532
https://pubmed.ncbi.nlm.nih.gov/9349532
Autor:
Virginia L. Smith-Swintosky
Publikováno v:
Neuroprotective Signal Transduction ISBN: 9781475759686
Thrombin is a 37 kDa glycosylated trypsin-like serine protease that has multiple biological functions. It is formed from a precursor protein, the zymogen prothrombin, by a complex of Factor Xa, Va, phospholipid, and calcium (Tracy et al., 1981). Prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51a2b28438e6a92275926aede90c336c
https://doi.org/10.1007/978-1-59259-475-7_13
https://doi.org/10.1007/978-1-59259-475-7_13