Hyperimmune immunoglobulin for hospitalised patients with COVID-19 (ITAC): a double-blind, placebo-controlled, phase 3, randomised trial

Autor: Mark N. Polizzotto, Jacqueline Nordwall, Abdel G. Babiker, Andrew Phillips, David M. Vock, Nnakelu Eriobu, Vivian Kwaghe, Roger Paredes, Lourdes Mateu, Srikanth Ramachandruni, Rajeev Narang, Mamta K. Jain, Susana M. Lazarte, Jason V. Baker, Anne E.P. Frosch, Garyfallia Poulakou, Konstantinos N. Syrigos, Gretchen S. Arnoczy, Natalie A. McBride, Philip A. Robinson, Farjad Sarafian, Sanjay Bhagani, Hassan S. Taha, Thomas Benfield, Sean T.H. Liu, Anastasia Antoniadou, Jens Ulrik Stæhr Jensen, Ioannis Kalomenidis, Adityo Susilo, Prasetyo Hariadi, Tomas O. Jensen MD, Jose Luis Morales-Rull, Marie Helleberg, Sreenath Meegada, Isik S. Johansen, Daniel Canario, Eduardo Fernández-Cruz, Simeon Metallidis, Amish Shah, Aki Sakurai, Nikolaos G. Koulouris, Robin Trotman, Amy C. Weintrob, Daria Podlekareva, Usman Hadi, Kathryn M. Lloyd, Birgit Thorup Røge, Sho Saito, Kelly Sweerus, Jakob J. Malin, Christoph Lübbert, Jose Muñoz, Matthew J. Cummings, Marcelo H. Losso, Dan Turner, Kathryn Shaw-Saliba, Robin Dewar, Helene Highbarger, Perrine Lallemand, Tauseef Rehman, Norman Gerry, Dona Arlinda, Christina C. Chang, Birgit Grund, Michael R. Holbrook, Horace P. Holley, Fleur Hudson, Laura A. McNay, Daniel D. Murray, Sarah L. Pett, Megan Shaughnessy, Mary C. Smolskis, Giota Touloumi, Mary E. Wright, Mittie K. Doyle, Sharon Popik, Christine Hall, Roshan Ramanathan, Huyen Cao, Elsa Mondou, Todd Willis, Joseph V. Thakuria, Leman Yel, Elizabeth Higgs, Virginia L. Kan, Jens D. Lundgren, James D. Neaton, H. Clifford Lane

Publikováno v: Lancet (London, England)

Background Passive immunotherapy using hyperimmune intravenous immunoglobulin (hIVIG) to SARS-CoV-2, derived from recovered donors, is a potential rapidly available, specific therapy for an outbreak infection such as SARS-CoV-2. Findings from randomi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3fa915184eaa7554ec475c89515acde
https://doi.org/10.1016/s0140-6736(22)00101-5

Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3)

Autor: Barnaby Edward Young, Shweta Sharma, B. Taylor Thompson, Virginia L. Kan, Christina E. Barkauskas, Abdel Babiker, Andrew N. Phillips, Thomas A. Murray, Roger Paredes, Mahesh K. B. Parmar, Cavan S. Reilly, Elizabeth S. Higgs, Uriel Sandkovsky, Christina C. Chang, Annetine C. Gelijns, H. Clifford Lane, Jason V. Baker, Sarah Pett, Mark N. Polizzotto, James D. Neaton, Victoria J. Davey, Birgit Grund, Fleur Hudson, Adit A. Ginde, Jens D Lundgren, Samuel M. Brown, Daniel D Murray, Marc Teitelbaum

Publikováno v: Clinical Trials
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
medRxiv
article-version (status) pre
article-version (number) 2
Clin Trials
Murray, D D, Babiker, A G, Baker, J V, Barkauskas, C E, Brown, S M, Chang, C C, Davey, V J, Gelijns, A C, Ginde, A A, Grund, B, Higgs, E, Hudson, F, Kan, V L, Lane, H C, Murray, T A, Paredes, R, Parmar, M K B, Pett, S, Phillips, A N, Polizzotto, M N, Reilly, C, Sandkovsky, U, Sharma, S, Teitelbaum, M, Thompson, B T, Young, B E, Neaton, J D & Lundgren, J D 2022, ' Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents : Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3) ', Clinical Trials, vol. 19, no. 1, pp. 52-61 . https://doi.org/10.1177/17407745211049829

Background/aims Safe and effective therapies for COVID-19 are urgently needed. In order to meet this need, the Accelerating COVID-19 Therapeutic Interventions and Vaccines public–private partnership initiated the Therapeutics for Inpatients with CO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dec5ed7ba827b3d90675389167dcfe9
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1602

Human Immunotypes Impose Selection on Viral Genotypes Through Viral Epitope Specificity

Autor: Dan Turner, Huldrych F. Günthard, Mark N. Polizzotto, Rasmus L. Marvig, Sandra E. Safo, James D. Neaton, Migle Gabrielaite, Giota Touloumi, Daniel D Murray, Adrian G. Zucco, Christina Ekenberg, H. Clifford Lane, Alejandro Arenas-Pinto, Linos Vandekerckhove, Virginia L. Kan, Marc Bennedbæk, Jens D Lundgren

Publikováno v: Gabrielaite, M, Bennedbæk, M, Zucco, A G, Ekenberg, C, Murray, D D, Kan, V L, Touloumi, G, Vandekerckhove, L, Turner, D, Neaton, J, Clifford Lane, H, Safo, S, Arenas-Pinto, A, Polizzotto, M N, Günthard, H F, Lundgren, J D & Marvig, R L 2021, ' Human Immunotypes Impose Selection on Viral Genotypes Through Viral Epitope Specificity ', Journal of Infectious Diseases, vol. 224, no. 12, pp. 2053-2063 . https://doi.org/10.1093/infdis/jiab253
J Infect Dis

BackgroundUnderstanding the genetic interplay between human hosts and infectious pathogens is crucial for how we interpret virulence factors. Here, we tested for associations between HIV and host genetics, and interactive genetic effects on viral loa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ca9c0e187f83dc25bde01e8e7f6c4a
https://curis.ku.dk/portal/da/publications/human-immunotypes-impose-selection-on-viral-genotypes-through-viral-epitope-specificity(877c7699-abfe-4433-b460-b947a95ac60e).html

A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19

Autor: Mahesh K. B. Parmar, D. Clark Files, Norman Markowitz, Shweta Sharma, Huyen Cao, Robin L. Dewar, Virginia L. Kan, Robert L. Gottlieb, Roger Paredes, Christina C. Chang, Andrew N. Phillips, Edward M. Gardner, Christina E. Barkauskas, J D Lundgren, H. Clifford Lane, Michael A. Matthay, Mamta K Jain, Lars Østergaard, Wesley H. Self, James D. Neaton, Kirk U. Knowlton, Estelle S. Harris, Cavan S. Reilly, Adit A. Ginde, Bradley G Leshnower, Thomas A. Murray, Mark N. Polizzotto, Isik Somuncu Johansen, Annetine C. Gelijns, Jens-Ulrik Stæhr Jensen, Uriel Sandkovsky, Abdel Babiker, Anna L. Goodman, Daniel D Murray, Marc Teitelbaum, T. Benfield, Samuel M. Brown, B. Taylor Thompson, Michael E Bowdish, Thomas L. Holland, Elizabeth S. Higgs, Paul Klekotka, Victoria J. Davey, Jason V. Baker, Deborah Wentworth, Birgit Grund

Publikováno v: ACTIV-3/TICO LY-CoV555 Study Group 2021, ' A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19 ', The New England Journal of Medicine, vol. 384, no. 10, pp. 905-914 . https://doi.org/10.1056/NEJMoa2033130
The New England Journal of Medicine
ACTIV-3/TICO LY-CoV555 Study Group 2021, ' A neutralizing monoclonal antibody for hospitalized patients with Covid-19 ', New England Journal of Medicine, vol. 384, no. 10, pp. 905-914 . https://doi.org/10.1056/NEJMoa2033130
Lundgren, J D, Grund, B, Barkauskas, C E, Holland, T L, Gottlieb, R L, Sandkovsky, U, Brown, S M, Knowlton, K U, Self, W H, Files, D C, Jain, M K, Benfield, T, Bowdish, M E, Leshnower, B G, Baker, J V, Jensen, J-U, Gardner, E M, Ginde, A A, Harris, E S, Johansen, I S, Markowitz, N, Matthay, M A, Østergaard, L, Chang, C C, Davey, V J, Goodman, A, Higgs, E S, Murray, D D, Murray, T A, Paredes, R, Parmar, M K B, Phillips, A N, Reilly, C, Sharma, S, Dewar, R L, Teitelbaum, M, Wentworth, D, Cao, H, Klekotka, P, Babiker, A G, Gelijns, A C, Kan, V L, Polizzotto, M N, Thompson, B T, Lane, H C, Neaton, J D, TICO Study Group, Nielsen, H, ACTIV-3/TICO LY-CoV555 Study Group & Writing Commitee 2021, ' A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19 ', The New England Journal of Medicine, vol. 384, no. 10, pp. 905-914 . https://doi.org/10.1056/NEJMoa2033130
Lundgren, J D, Grund, B, Barkauskas, C E, Holland, T L, Gottlieb, R L, Sandkovsky, U, Brown, S M, Knowlton, K U, Self, W H, Files, D C, Jain, M K, Benfield, T, Bowdish, M E, Leshnower, B G, Baker, J V, Jensen, J U, Gardner, E M, Ginde, A A, Harris, E S, Johansen, I S, Markowitz, N, Matthay, M A, Østergaard, L, Chang, C C, Davey, V J, Goodman, A, Higgs, E S, Murray, D D, Murray, T A, Paredes, R, Parmar, M K B, Phillips, A N, Reilly, C, Sharma, S, Dewar, R L, Teitelbaum, M, Wentworth, D, Cao, H, Klekotka, P, Babiker, A G, Gelijns, A C, Kan, V L, Polizzotto, M N, Thompson, B T, Lane, H C, Neaton, J D & ACTIV-3/TICO LY-CoV555 Study Group 2021, ' A neutralizing monoclonal antibody for hospitalized patients with Covid-19 ', New England Journal of Medicine, vol. 384, no. 10, pp. 905-914 . https://doi.org/10.1056/NEJMoa2033130

BACKGROUND: LY-CoV555, a neutralizing monoclonal antibody, has been associated with a decrease in viral load and the frequency of hospitalizations or emergency department visits among outpatients with coronavirus disease 2019 (Covid-19). Data are nee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ce0f48cdc3d3923c058149b17fe8dd
https://pure.au.dk/portal/da/publications/a-neutralizing-monoclonal-antibody-for-hospitalized-patients-with-covid19(f31200af-4c9e-4290-9824-4f4f1fc165d1).html

Metabolite profiles associated with disease progression in influenza infection

Autor: Nikolaos Koulouris, Virginia L. Kan, Sarah Pett, Timothy J. Griffin, Javier Carbone, James D. Neaton, Cavan S. Reilly, Chris H. Wendt, Sandra Castro-Pearson, Jennifer Proper

Publikováno v: PLoS ONE, Vol 16, Iss 4, p e0247493 (2021)
PLoS ONE

Background We performed metabolomic profiling to identify metabolites that correlate with disease progression and death. Methods We performed a study of adults hospitalized with Influenza A(H1N1)pdm09. Cases (n = 32) were defined by a composite outco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f7c7e235411b6281e225033435f513
https://doaj.org/article/607f78ee821241608c478577a9e8d3a5