Targeted Sequencing of FKBP5 in Suicide Attempters with Bipolar Disorder.

Autor: Marie E Breen, Sophia C Gaynor, Eric T Monson, Kelly de Klerk, Meredith G Parsons, Terry A Braun, Adam P DeLuca, Peter P Zandi, James B Potash, Virginia L Willour

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0169158 (2016)

FKBP5 is a critical component of the Hypothalamic-Pituitary-Adrenal (HPA) axis, a system which regulates our response to stress. It forms part of a complex of chaperones, which inhibits binding of cortisol and glucocorticoid receptor translocation to

Externí odkaz: https://doaj.org/article/7c606df0916449fb89c517ccbf0a7519

Chronic social stress induces DNA methylation changes at an evolutionary conserved intergenic region in chromosome X

Autor: Benjamin Hing, Patricia Braun, Zachary A. Cordner, Erin R. Ewald, Laura Moody, Melissa McKane, Virginia L. Willour, Kellie L. Tamashiro, James B. Potash

Publikováno v: Epigenetics, Vol 13, Iss 6, Pp 627-641 (2018)

Chronic stress resulting from prolonged exposure to negative life events increases the risk of mood and anxiety disorders. Although chronic stress can change gene expression relevant for behavior, molecular regulators of this change have not been ful

Externí odkaz: https://doaj.org/article/bdec0786fbca411fb452cbf4418fb2ed

Assessment of suicide attempt and death in bipolar affective disorder: a combined clinical and genetic approach

Autor: Hilary Coon, Anna R. Docherty, Amanda V. Bakian, Eric T. Monson, Emily DiBlasi, Brooks R. Keeshin, Virginia L. Willour, Sheila E. Crowell, Niamh Mullins, Douglas Gray, Qingqin S. Li, Andrey A. Shabalin

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Translational Psychiatry

Bipolar disorder (BP) suicide death rates are 10–30 times greater than the general population, likely arising from environmental and genetic risk factors. Though suicidal behavior in BP has been investigated, studies have not addressed combined cli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ce43d9f69cdf2673a4cafae517ee85
https://doaj.org/article/eaefc5bd42cf41b9a7782f258e8aff16

Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder

Autor: Arianna DiFlorio, Patrick F. Sullivan, Sebastian Zöllner, Margarita Rivera, Richard M. Myers, Stanley J. Watson, Jun Li, Anders Juréus, Sarah E. Bergen, Gonçalo R. Abecasis, Jordan W. Smoller, Michael Conlon O'Donovan, Neil Risch, Hoang T. Nguyen, Chen Jiang, Xiaoming Jia, Mehdi Pirooznia, Danielle Posthuma, Adam E. Locke, Peter P. Zandi, John B. Vincent, Niamh Mullins, Duncan Palmer, Shaun Purcell, Gerome Breen, Christina M. Hultman, Andreas Reif, Khanh K. Thai, Virginia L. Willour, Pui-Yan Kwok, Laura J. Scott, Anne U. Jackson, Michael John Owen, Fernando S. Goes, Steven A. McCarroll, James B. Potash, Mikael Landén, Jennifer L. Moran, Michele T. Pato, Hyun Min Kang, Marco P. Boks, Sinéad B. Chapman, W. Richard McCombie, Janet L. Sobell, Matthew Zawistowski, Rolf Adolfsson, Yongwen Zhuang, Michael Boehnke, René S. Kahn, Huda Akil, James T.R. Walters, Margit Burmeister, Douglas Blackwood, Cathryn M. Lewis, Eli A. Stahl, Mark N. Kvale, Melissa DelaBastide, Catherine Schaefer, Benjamin M. Neale, Giulio Genovese, Carlos N. Pato, Nicholas John Craddock, Andrew McQuillin, Shawn Levy, Aiden Corvin, Pamela Sklar, Weiqing Wang, Andrew M. McIntosh, Ling Shen, Eric T. Monson, Derek W. Morris, Douglas M. Ruderfer, Roel A. Ophoff, Peter McGuffin, Sarah Cohen-Woods, Willem H. Ouwehand

Publikováno v: Molecular Psychiatry, 26(9), 5239-5250. Nature Publishing Group
Molecular psychiatry, vol 26, iss 9
Jia, X, Goes, F S, Locke, A E, Palmer, D, Wang, W, Cohen-Woods, S, Genovese, G, Jackson, A U, Jiang, C, Kvale, M, Mullins, N, Nguyen, H, Pirooznia, M, Rivera, M, Ruderfer, D M, Shen, L, Thai, K, Zawistowski, M, Zhuang, Y, Abecasis, G, Akil, H, Bergen, S, Burmeister, M, Chapman, S, DelaBastide, M, Juréus, A, Kang, H M, Kwok, P Y, Li, J Z, Levy, S E, Monson, E T, Moran, J, Sobell, J, Watson, S, Willour, V, Zöllner, S, Adolfsson, R, Blackwood, D, Boehnke, M, Breen, G, Corvin, A, Craddock, N, DiFlorio, A, Hultman, C M, Landen, M, Lewis, C, McCarroll, S A, Richard McCombie, W, McGuffin, P, McIntosh, A, McQuillin, A, Morris, D, Myers, R M, O’Donovan, M, Ophoff, R, Boks, M, Kahn, R, Ouwehand, W, Owen, M, Pato, C, Pato, M, Posthuma, D, Potash, J B, Reif, A, Sklar, P, Smoller, J, Sullivan, P F, Vincent, J, Walters, J, Neale, B, Purcell, S, Risch, N, Schaefer, C, Stahl, E A, Zandi, P P & Scott, L J 2021, ' Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder ', Molecular Psychiatry, vol. 26, no. 9, pp. 5239-5250 . https://doi.org/10.1038/s41380-020-01006-9
Molecular Psychiatry
Jia, X, Goes, F S, Locke, A E, Palmer, D, Wang, W, Cohen-Woods, S, Genovese, G, Jackson, A U, Jiang, C, Kvale, M, Mullins, N, Nguyen, H, Pirooznia, M, Rivera, M, Ruderfer, D M, Shen, L, Thai, K, Zawistowski, M, Zhuang, Y, Abecasis, G, Akil, H, Bergen, S, Burmeister, M, Champion, S, DelaBastide, M, Juréus, A, Kang, H M, Kwok, P-Y, Li, J Z, Levy, S E, Monson, E T, Moran, J, Sobell, J, Watson, S, Willour, V, Zöllner, S, Adolfsson, R, Blackwood, D, Boehnke, M, Breen, G, Corvin, A, Craddock, N, DiFlorio, A, Hultman, C M, Landen, M, Lewis, C, McCarroll, S A, Richard McCombie, W, McGuffin, P, McIntosh, A, McQuillin, A, Morris, D, Myers, R M, O’Donovan, M, Ophoff, R, Boks, M, Kahn, R, Ouwehand, W, Owen, M, Pato, C, Pato, M, Posthuma, D, Potash, J B, Reif, A, Sklar, P, Smoller, J, Sullivan, P F, Vincent, J, Walters, J, Neale, B, Purcell, S, Risch, N, Schaefer, C, Stahl, E A, Zandi, P P & Scott, L J 2021, ' Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder ', Molecular Psychiatry, vol. 26, no. 9, pp. 5239-5250 . https://doi.org/10.1038/s41380-020-01006-9
Jia, X, Goes, F S, Locke, A E, Palmer, D, Wang, W, Cohen-woods, S, Genovese, G, Jackson, A U, Jiang, C, Kvale, M, Mullins, N, Nguyen, H, Pirooznia, M, Rivera, M, Ruderfer, D M, Shen, L, Thai, K, Zawistowski, M, Zhuang, Y, Abecasis, G, Akil, H, Bergen, S, Burmeister, M, Chapman, S, Delabastide, M, Juréus, A, Kang, H M, Kwok, P, Li, J Z, Levy, S E, Monson, E T, Moran, J, Sobell, J, Watson, S, Willour, V, Zöllner, S, Adolfsson, R, Blackwood, D, Boehnke, M, Breen, G, Corvin, A, Craddock, N, Diflorio, A, Hultman, C M, Landen, M, Lewis, C, Mccarroll, S A, Richard Mccombie, W, Mcguffin, P, Mcintosh, A, Mcquillin, A, Morris, D, Myers, R M, O’donovan, M, Ophoff, R, Boks, M, Kahn, R, Ouwehand, W, Owen, M, Pato, C, Pato, M, Posthuma, D, Potash, J B, Reif, A, Sklar, P, Smoller, J, Sullivan, P F, Vincent, J, Walters, J, Neale, B, Purcell, S, Risch, N, Schaefer, C, Stahl, E A, Zandi, P P & Scott, L J 2021, ' Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder ', Molecular Psychiatry . https://doi.org/10.1038/s41380-020-01006-9
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)

Bipolar disorder (BD) is a serious mental illness with substantial common variant heritability. However, the role of rare coding variation in BD is not well established. We examined the protein-coding (exonic) sequences of 3,987 unrelated individuals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b28270dff0616afd7d691245b0f9b8
https://research.vu.nl/en/publications/5db60cd7-dd49-4271-b724-a8cb3ceb8d2c

Article The Familial Aggregation of Psychotic Symptoms in Bipolar Disorder Pedigrees

Autor: Yen Feng Chiu, James B. Potash, M. G. Mclnnis, Sylvia G. Simpson, Virginia L. Willour, J. Raymond DePaulo, Godfrey D. Pearlson, Dean F. MacKinnon

Publikováno v: The Science of Mental Health

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df5ef7a3299c9357a9c2951b3cf36349
https://doi.org/10.4324/9781315054308-6