Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Virginia L Calder"'
Publikováno v:
Cells, Vol 10, Iss 2, p 396 (2021)
Retinal vascular diseases have distinct, complex and multifactorial pathogeneses yet share several key pathophysiological aspects including inflammation, vascular permeability and neovascularisation. In non-infectious posterior uveitis (NIU), retinal
Externí odkaz:
https://doaj.org/article/8d65c773d1a449dab94bf6ae4fb69688
Autor:
Arnulf Hertweck, Catherine M. Evans, Malihe Eskandarpour, Jonathan C.H. Lau, Kristine Oleinika, Ian Jackson, Audrey Kelly, John Ambrose, Peter Adamson, David J. Cousins, Paul Lavender, Virginia L. Calder, Graham M. Lord, Richard G. Jenner
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2756-2770 (2016)
The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers to allow the recruitment
Externí odkaz:
https://doaj.org/article/62e0042e1c2743aca84f38295c4cab13
Autor:
Rose M. Gilbert, Xiaozhe Zhang, Robert D. Sampson, Michael R. Ehrenstein, Dao X. Nguyen, Mahid Chaudhry, Charles Mein, Nadiya Mahmud, Grazyna Galatowicz, Oren Tomkins-Netzer, Virginia L. Calder, Sue Lightman
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
BackgroundNon-infectious uveitis can cause chronic relapsing and remitting ocular inflammation, which may require high dose systemic immunosuppression to prevent severe sight loss. It has been classically described as an autoimmune disease, mediated
Externí odkaz:
https://doaj.org/article/b42b99a840f043ffb206c156e89239dc
Autor:
Wynne Weston-Davies, Virginia L. Calder, Malihe Eskandarpour, Sarah E. Coupland, Miles A. Nunn, Yi-Hsing Chen
Publikováno v:
The American Journal of Pathology. 191:320-334
Nomacopan, a drug originally derived from tick saliva, has dual functions of sequestering leukotriene B4 (LTB4) and inhibiting complement component 5 (C5) activation. Nomacopan has been shown to provide therapeutic benefit in experimental autoimmune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a64a7e26ecb63b7fe16916c92b9a531
https://doi.org/10.1016/j.ajpath.2020.10.010
https://doi.org/10.1016/j.ajpath.2020.10.010
Autor:
Virginia L. Calder, Susan Lightman, G. Galatowicz, Renyang Gu, Xiaozhe Zhang, Aurelia Gondrand, Y.–H. Chen, Malihe Eskandarpour
Publikováno v:
European Journal of Immunology. 50:1941-1951
Immunopathogenic roles for both Th1 (CD4+ IFN-γ+ ) and Th17 (CD4+ IL-17A+ ) cells have been demonstrated in experimental autoimmune uveitis (EAU). However, the role for Th17/Th1 (CD4+ T cells co-expressing IFN-γ and IL-17A) cells in EAU is not yet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7c51e3ddf1d1c43c6f66ee96c184dae
https://doi.org/10.1002/eji.202048616
https://doi.org/10.1002/eji.202048616
Publikováno v:
Journal of visualized experiments : JoVE. (179)
Experimental Autoimmune Uveitis (EAU) is driven by immune cells responding to self-antigens. Many features of this non-infectious, intraocular inflammatory disease model recapitulate the clinical phenotype of posterior uveitis affecting humans. EAU h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4045587abf024f7c12bae14b2694efaf
https://pubmed.ncbi.nlm.nih.gov/35098942
https://pubmed.ncbi.nlm.nih.gov/35098942
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 503, p 503 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Non-infectious uveitis (NIU) is an inflammatory eye disease initiated via CD4+ T-cell activation and transmigration, resulting in focal retinal tissue damage and visual acuity disturbance. Cell adhesion molecules (CAMs) are activated during the infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4bbb186542775dcb988b369fd681d8
https://www.mdpi.com/1422-0067/23/1/503
https://www.mdpi.com/1422-0067/23/1/503
Autor:
Xiaozhe Zhang, Stefano Bonini, Virginia L. Calder, Wynne Weston-Davies, Alessandra Micera, Sarah S. Zaher, Frank Larkin, Miles A. Nunn, Malihe Eskandarpour
Publikováno v:
Allergy. 77(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a362d3c0e86e8e7541adbe36c9589c2
https://pubmed.ncbi.nlm.nih.gov/34614221
https://pubmed.ncbi.nlm.nih.gov/34614221
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9584, p 9584 (2021)
Non-infectious uveitis (NIU) is a potentially sight-threatening disease. Effector CD4+ T cells, especially interferon-γ-(IFNγ) producing Th1 cells and interleukin-17-(IL-17) producing Th17 cells, are the major immunopathogenic cells, as demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5343fa20751245e863e2a1894a82c8
https://www.mdpi.com/1422-0067/22/17/9584
https://www.mdpi.com/1422-0067/22/17/9584
Publikováno v:
International Journal of Molecular Sciences
Non-infectious uveitis (NIU) is a potentially sight-threatening disease. Effector CD4+ T cells, especially interferon-γ-(IFNγ) producing Th1 cells and interleukin-17-(IL-17) producing Th17 cells, are the major immunopathogenic cells, as demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1a629ade38a99babc6cbabb28cdd944
https://pubmed.ncbi.nlm.nih.gov/34502490
https://pubmed.ncbi.nlm.nih.gov/34502490