Výsledky vyhledávání - "Virginia Kocieda"

Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression

Autor: Doina Ganea, Sabina Adhikary, Virginia Kocieda, Jui-Hung Yen, Ronald F. Tuma

Publikováno v: Blood. 120:3741-3749

Administration of cannabinoid receptor 2 (CB2R) agonists in inflammatory and autoimmune disease and CNS injury models results in significant attenuation of clinical disease, and reduction of inflammatory mediators. Previous studies reported that CB2R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a1c20857e4efd1bdd75b701a049f5b
https://doi.org/10.1182/blood-2012-06-435362

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Prostaglandin E2-induced IL-23p19 Subunit Is Regulated by cAMP-responsive Element-binding Protein and C/AATT Enhancer-binding Protein β in Bone Marrow-derived Dendritic Cells

Autor: Miguel G. Toscano, Doina Ganea, Sabina Adhikary, Jui-Hung Yen, Frances A. Emig, Virginia Kocieda

Publikováno v: Journal of Biological Chemistry. 287:36922-36935

We reported previously that prostaglandin E2 (PGE2) up-regulates IL-23 in vitro in bone marrow-derived dendritic cells and in vivo in models of collagen-induced arthritis and inflammatory bowel disease, leading to preferential Th17 development and ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6845da1fba09150a91bd1bac05b092ce
https://doi.org/10.1074/jbc.m112.402958

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Prostaglandin E2 Induces Matrix Metalloproteinase 9 Expression in Dendritic Cells through Two Independent Signaling Pathways Leading to Activator Protein 1 (AP-1) Activation

Autor: Huie Jing, Doina Ganea, Jui-Hung Yen, Virginia Kocieda

Publikováno v: Journal of Biological Chemistry. 286:38913-38923

Dendritic Cells (DCs) play an important role in the initiation of the immune response by migrating to regional lymph nodes and presenting antigen processed at the inflammatory site to antigen-specific naïve T cells. Prostaglandin E2 (PGE2) has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c686d38fe3de134720ba94fdd0887521
https://doi.org/10.1074/jbc.m111.252932

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Modulation of dendritic cell function by PGE2 and DHA: a framework for understanding the role of dendritic cells in neuroinflammation

Autor: Jui-Hung Yen, Weimin Kong, Doina Ganea, Virginia Kocieda

Publikováno v: Clinical Lipidology. 6:277-291

Neuroinflammation characterizes various neurological disorders. Peripheral immune cells and CNS-resident glia contribute to neuroinflammation and impact CNS degeneration, recovery and regeneration. Recently, the role of dendritic cells in neuroinflam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc20379fd22573170b5dd58a1c7592d
https://doi.org/10.2217/clp.11.12

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Persistent anti-gag, -Nef, and -Rev IgM levels as markers of the impaired functions of CD4+ T-helper lymphocytes during SIVmac251 infection of cynomolgus macaques

Autor: Jay Rappaport, Kamel Khalili, Peter Silvera, Emmanuel G. Régulier, Max W. Richardson, Jeremy J DeFranco, Devon C Gordon-Lyles, Reshma Panemangalore, Mark G. Lewis, Jean-François Zagury, Virginia Kocieda

Publikováno v: Journal of acquired immune deficiency syndromes (1999). 40(1)

Summary: This study analyzed the antigen-specific (Gag, Nef, Rev, and Tat) IgM, IgG, and IgA humoral responses during the first 200 days of SIVmac251 infection in cynomolgus macaques. These responses were tested for correlation with the CD4+ T-cell-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ed78e96ed23d384a74458ffe6f252b
https://pubmed.ncbi.nlm.nih.gov/16123674

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Cannabinoid receptor 2 agonists inhibit migration of activated dendritic cells via modulation of MMP-9 (173.23)

Autor: Sabina Adhikary, Virginia Kocieda, Doina Ganea

Publikováno v: The Journal of Immunology. 188:173.23-173.23

In murine models of multiple sclerosis (experimental autoimmune encephalomyelitis or EAE), cannabinoid receptor 2 (CB2) agonists have been shown to be beneficial, reducing the number of CNS infiltrating leukocytes. Adhesion molecules, chemokines, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05321a2c759b8c3d24871c9d5a89af64
https://doi.org/10.4049/jimmunol.188.supp.173.23

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ERK activation is required for PGE2-induced MMP-9 production in bone-morrow derived DCs (112.23)

Autor: Jui-Hung Yen, Virginia Kocieda, Doina Ganea

Publikováno v: The Journal of Immunology. 186:112.23-112.23

Dendritic Cells (DCs) play an important role in the initiation of the immune response. Immature DCs take up antigen, mature and migrate to the regional lymph nodes where they activate antigen-specific naïve T cells. Prostaglandins such as PGE2 are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4d7d3df078d67c8a2aa85469033bea8
https://doi.org/10.4049/jimmunol.186.supp.112.23

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CREB is an essential transcription factor for prostaglandin E2 induced IL-23p19 (116.18)

Autor: Virginia Kocieda, Sabina Adhikary, Fran Emig, Doina Ganea

Publikováno v: The Journal of Immunology. 186:116.18-116.18

We reported previously that PGE2 promotes IL-23p19 expression in dendritic cells (DC) treated with LPS. The effect is mediated through EP4 through the induction of cAMP. This study is focused on the signaling pathways involved in PGE1OH (an EP4 agoni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb248eeaeefae0df9b214e3818657cce
https://doi.org/10.4049/jimmunol.186.supp.116.18

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Prostaglandin E2 Receptor Signaling Induces IL-23p19 Expression through CREB and STAT-3 Transcriptional Regulation (98.2)

Autor: Virginia Kocieda, Sabina Adhikary, Fran Emig, Doina Ganea

Publikováno v: The Journal of Immunology. 184:98.2-98.2

Previously, we have shown that PGE2 inhibits IL-12p35 expression & promotes IL-23p19 expression in dendritic cells (DC) treated with LPS or Poly I:C. The effect is mediated through EP4 and to a lesser degree EP2 receptors and induction of cAMP. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73324d02a43ce841d4722592344854c4
https://doi.org/10.4049/jimmunol.184.supp.98.2

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