Výsledky vyhledávání - "Virginia Gutierrez De Juan"

Akademický článek

Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

High methionine and S-adenosylmethionine serum levels are related with obesity. Here the authors show that knockdown of methionine adenosyltransferase by using antisense oligonucleotides provides beneficial effects in obesity and comorbidities.

Externí odkaz: https://doaj.org/article/679efae112224ba6a2829203d49df6dc

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Supplementary Table 1 from E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment

Supplementary Table 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ddf213946fc87fd4f283ab64b4cde07
https://doi.org/10.1158/0008-5472.22430244

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Data from E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment

Lipid metabolism rearrangements in nonalcoholic fatty liver disease (NAFLD) contribute to disease progression. NAFLD has emerged as a major risk for hepatocellular carcinoma (HCC), where metabolic reprogramming is a hallmark. Identification of metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a5c6a7e5944231bd4c670412d55b9a1
https://doi.org/10.1158/0008-5472.c.6513576.v1

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Supplementary Information from E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment

1-Supplementary methods 2-Supplementary Figure legends 3-Supplementary references

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c113bd0a2cdcb35d220f3dc823b4840
https://doi.org/10.1158/0008-5472.22430247.v1

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Akademický článek

Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis

Publikováno v: Gut Microbes, Vol 15, Iss 2 (2023)

ABSTRACTAnti-TNF therapy can induce and maintain a remission status during intestinal bowel disease. However, up to 30% of patients do not respond to this therapy by mechanisms that are unknown. Here, we show that the absence of MCJ, a natural inhibi

Externí odkaz: https://doaj.org/article/a753bfcd4ae14ccb8c85e30af3536b86

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Akademický článek

Hyperphosphorylation of hepatic proteome characterizes nonalcoholic fatty liver disease in S-adenosylmethionine deficiency

Autor: Aaron E. Robinson, Aleksandra Binek, Komal Ramani, Niveda Sundararaman, Lucía Barbier-Torres, Ben Murray, Vidya Venkatraman, Simion Kreimer, Angela Mc Ardle, Mazen Noureddin, David Fernández-Ramos, Fernando Lopitz-Otsoa, Virginia Gutiérrez de Juan, Oscar Millet, José M. Mato, Shelly C. Lu, Jennifer E. Van Eyk

Publikováno v: iScience, Vol 26, Iss 2, Pp 105987- (2023)

Summary: Methionine adenosyltransferase 1a (MAT1A) is responsible for hepatic S-adenosyl-L-methionine (SAMe) biosynthesis. Mat1a−/− mice have hepatic SAMe depletion, develop nonalcoholic steatohepatitis (NASH) which is reversed with SAMe administ

Externí odkaz: https://doaj.org/article/5a0db57b521d4dd29148c78a30164d06

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Akademický článek

Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Non-alcoholic fatty liver (NAFLD) disease causes degeneration of the liver, affects about 25% of people globally, and has no approved treatment. Here, the authors show that the therapeutic siRNA-driven silencing of MCJ in the liver is an effective an

Externí odkaz: https://doaj.org/article/f4585c15ec8641c2ad4a105f86c1a9ca

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Akademický článek

Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis

Publikováno v: Molecular Metabolism, Vol 53, Iss , Pp 101275- (2021)

Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic fatty liver disease (NAFLD). Herein

Externí odkaz: https://doaj.org/article/358512f74108488aa4daf723e0bda944

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