Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Virginia Gray Johnson"'
Autor:
S. M. Andrew, Richard J. Youle, Jef C. M. Raus, H. R. Hoogenboom, Virginia Gray Johnson, P. J. Nicholls
Publikováno v:
Journal of Biological Chemistry. 268:5302-5308
Chimeric proteins consisting of a fusion between binding-deficient mutants of diphtheria toxin (DT) or Pseudomonas exotoxin A (PE) and a single-chain antibody (E6 sFv) against the human transferrin receptor (TfnR) were expressed in a rabbit reticuloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0680818f7c6b73cb4d619ac56c41598
https://doi.org/10.1016/s0021-9258(18)53533-x
https://doi.org/10.1016/s0021-9258(18)53533-x
Autor:
Virginia Gray Johnson
Publikováno v:
Science. 250:832-834
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad069926fbe987da47bbea2c56ec438b
https://doi.org/10.1126/science.250.4982.832-a
https://doi.org/10.1126/science.250.4982.832-a
Autor:
Virginia Gray Johnson
Publikováno v:
Science. 250:832-834
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfec3a6c3b3328059f57b65f7d206dc
https://doi.org/10.1126/science.250.4982.832-b
https://doi.org/10.1126/science.250.4982.832-b
Publikováno v:
Journal of immunological methods. 165(1)
Cloning the correct VL kappa gene from hybridomas derived from MOPC-21 can be problematic because such cell lines variably express a transcript which is aberrantly rearranged at the VJ recombination site. Cellular levels of the aberrant transcript ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7dfa03d596c76fc20c95c5ba8cc763
https://pubmed.ncbi.nlm.nih.gov/8409471
https://pubmed.ncbi.nlm.nih.gov/8409471
Publikováno v:
Journal of Biological Chemistry. 263:1295-1300
The role of the receptor in the transport of diphtheria toxin (DT) to the cytosol was examined. A point-mutant form of DT, CRM 107 (CRM represents cross-reacting material), that has an 8,000-fold lower affinity for the DT receptor than native toxin w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f24830dfe3d7fd4c81cd771c9fdadddb
https://doi.org/10.1016/s0021-9258(19)57299-4
https://doi.org/10.1016/s0021-9258(19)57299-4
Publikováno v:
Journal of Biological Chemistry. 264:17739-17744
Diphtheria toxin (DT) is a soluble protein that translocates across hydrophobic lipid bilayers in response to low pH. The translocation activity of DT has been localized to the 40-kDa toxin B chain and can be expressed independently of the C-terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::488d44d516f267515cf96b06e59c5e81
https://doi.org/10.1016/s0021-9258(19)84633-1
https://doi.org/10.1016/s0021-9258(19)84633-1
Autor:
Virginia Gray Johnson, Richard J. Youle, Larry Greenfield, John Zovickian, Charles J. Wrobel, Debra J. Wilson, Edward H. Oldfield
Publikováno v:
Journal of neurosurgery. 70(2)
✓ A novel antibody-toxin conjugate has been developed for use in cancer therapy. This report demonstrates that this new reagent selectively kills glioblastoma- and medulloblastoma-derived cell lines, medulloblastoma cells in primary culture, and ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97987abe056922319fa667bb82f0c785
https://pubmed.ncbi.nlm.nih.gov/2783608
https://pubmed.ncbi.nlm.nih.gov/2783608
Publikováno v:
Science (New York, N.Y.). 238(4826)
Monoclonal antibodies linked to toxic proteins (immunotoxins) can selectively kill some tumor cells in vitro and in vivo. However, reagents that combine the full potency of the native toxins with the high degree of cell type selectivity of monoclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a860d18a3816f367f19a3cd89c442a15
https://pubmed.ncbi.nlm.nih.gov/3498987
https://pubmed.ncbi.nlm.nih.gov/3498987
Publikováno v:
Journal of neurosurgery. 66(6)
✓ Immunotoxins are hybrid molecules which combine the exquisite selectivity of monoclonal antibodies with the potent toxicity of protein toxins. An immunotoxin was constructed by linking a murine monoclonal antibody against the human transferrin re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a5039780db8fff92c6e214cba4c28b
https://pubmed.ncbi.nlm.nih.gov/3033171
https://pubmed.ncbi.nlm.nih.gov/3033171
Publikováno v:
Science. 132:1021-1021
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d0e0b51ab4f6f9707a3bb846de5cc9
https://doi.org/10.1126/science.132.3433.1021
https://doi.org/10.1126/science.132.3433.1021