Emerging evidence for the modulation of exocytosis by signalling lipids

Autor: José Villanueva, Virginia Garcia-Martinez, Yolanda Gimenez-Molina, Bazbek Davletov, Luis M. Gutiérrez, Frédéric Darios

Publikováno v: FEBS Letters
FEBS Letters, 2018, 592 (21), pp.3493-3503. ⟨10.1002/1873-3468.13178⟩
FEBS Letters, Wiley, 2018, 592 (21), pp.3493-3503. ⟨10.1002/1873-3468.13178⟩
Febs Letters

Membrane fusion is a key event in exocytosis of neurotransmitters and hormones stored in intracellular vesicles. In this process, soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins are essential components of the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ca1d6587b794dfc5353519df53303b
https://doi.org/10.1002/1873-3468.13178

Sphingomyelin derivatives increase the frequency of microvesicle and granule fusion in chromaffin cells

Autor: María Ángeles Montes, Virginia Garcia-Martinez, José Villanueva, Yolanda Gimenez-Molina, G.A. de Toledo, Luis M. Gutiérrez

Publikováno v: Neuroscience. 295:117-125

Sphingomyelin derivatives like sphingosine have been shown to enhance secretion in a variety of systems, including neuroendocrine and neuronal cells. By studying the mechanisms underlying this effect, we demonstrate here that sphingomyelin rafts co-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d2dee5c731abd1c36dd275a55373e1
https://doi.org/10.1016/j.neuroscience.2015.03.036

Metabolic activity of cerebellar and basal ganglia-thalamic neurons is reduced in parkinsonism

Autor: Chantal François, Maria Herrero, Merle Ruberg, Virginia Garcia-Martinez, Etienne C. Hirsch, Anne-Sophie Rolland

Publikováno v: Brain. 130:265-275

We have examined whether degeneration of nigrostriatal dopaminergic neurons causes dysfunction of both the basal ganglia-thalamic and cerebello-thalamic pathways. Changes in the activity of thalamic neurons receiving input from the basal ganglia or t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097c7eaa676ac26e5c355eeee2dfa94b
https://doi.org/10.1093/brain/awl337

Lipid Metabolites Enhance Secretion Acting on SNARE Microdomains and Altering the Extent and Kinetics of Single Release Events in Bovine Adrenal Chromaffin Cells

Autor: Victor M. Darley-Usmar, Luis M. Gutiérrez, José Villanueva, Cristina J. Torregrosa-Hetland, Bazbek Davletov, Virginia Garcia-Martinez, Ashlee N. Higdon, Robert Bittman

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 9, p e75845 (2013)

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Lipid mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd79fa0c88c999160bf53b5b50486dde
http://europepmc.org/articles/PMC3779176

Neurite extensions in chromaffin cells: Study of the influence of the cytoskeletal structure on calcium dynamics and secretion

Autor: José Villanueva, Salvador Viniegra, Virginia González-Vélez, Amparo Gil, Virginia Garcia-Martinez, Luis M. Gutiérrez, Javier Segura, Cristina J. Torregrosa-Hetland

The extension of neurites by bovine chromaffin cells in culture represents an opportunity to analyse the factors contributing to shape secretion from a round endocrine to a polarized neuronal model. Neurite-emitting chromaffin cells indeed present a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203b768887694a80053a689d53f687cd
http://hdl.handle.net/10261/309602