Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Virginia E, Papaioannou"'
Autor:
Daniel Concepcion, Andrew J. Washkowitz, Akiko DeSantis, Phillip Ogea, Jason I. Yang, Nataki C. Douglas, Virginia E. Papaioannou
Publikováno v:
Biology Open, Vol 6, Iss 7, Pp 1065-1073 (2017)
Tbx6 is a T-box transcription factor with multiple roles in embryonic development as evidenced by dramatic effects on mesoderm cell fate determination, left/right axis determination, and somite segmentation in mutant mice. The expression of Tbx6 is r
Externí odkaz:
https://doaj.org/article/05c0c47460f646a691502fbd2ef8ac1e
Publikováno v:
Biology Open, Vol 7, Iss 5 (2018)
The Tbx6 transcription factor plays multiple roles during gastrulation, somite formation and body axis determination. One of the notable features of the Tbx6 homozygous mutant phenotype is randomization of left/right axis determination. Cilia of the
Externí odkaz:
https://doaj.org/article/75442cf36cd64a369345b04327185489
Autor:
Virginia E. Papaioannou
Publikováno v:
Biographical Memoirs of Fellows of the Royal Society. 67:153-171
Salome Gluecksohn-Waelsch was a pioneer in establishing the field of mammalian developmental genetics, bringing together experimental embryology and genetics at a time when the role of genes in development was far from accepted. She studied in German
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d174546ea6d2bf3f076a9eda568b329
https://doi.org/10.1098/rsbm.2019.0024
https://doi.org/10.1098/rsbm.2019.0024
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70149 (2013)
Members of the T-box family of transcription factors are important regulators orchestrating the complex regionalization of the developing mammalian heart. Individual mutations in Tbx20 and Tbx3 cause distinct congenital heart abnormalities in the mou
Externí odkaz:
https://doaj.org/article/6ae811f8319b4351adc24a831f2795e7
Autor:
Francesca Lugani, Ripla Arora, Natalia Papeta, Ami Patel, Zongyu Zheng, Roel Sterken, Ruth A Singer, Gianluca Caridi, Cathy Mendelsohn, Lori Sussel, Virginia E Papaioannou, Ali G Gharavi
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003206 (2013)
Danforth's short tail mutant (Sd) mouse, first described in 1930, is a classic spontaneous mutant exhibiting defects of the axial skeleton, hindgut, and urogenital system. We used meiotic mapping in 1,497 segregants to localize the mutation to a 42.8
Externí odkaz:
https://doaj.org/article/5f4f2d23e14d4828a4b401726b1aba27
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43581 (2012)
Loss of Tbx4 results in absence of chorio-allantoic fusion and failure of formation of the primary vascular plexus of the allantois leading to embryonic death at E10.5. We reviewed the literature for genes implicated in chorio-allantoic fusion, cavit
Externí odkaz:
https://doaj.org/article/a45867e41b2c4f5c8ee9763b2cc5d540
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002866 (2012)
Normal development of the respiratory system is essential for survival and is regulated by multiple genes and signaling pathways. Both Tbx4 and Tbx5 are expressed throughout the mesenchyme of the developing lung and trachea; and, although multiple ge
Externí odkaz:
https://doaj.org/article/171ac9baff84436ba3cdb82cc5cd9538
Autor:
Svetlana Gavrilov, Darja Marolt, Nataki C. Douglas, Robert W. Prosser, Imran Khalid, Mark V. Sauer, Donald W. Landry, Gordana Vunjak-Novakovic, Virginia E. Papaioannou
Publikováno v:
Stem Cells International, Vol 2011 (2011)
We report the derivation and characterization of two new human embryonic stem cells (hESC) lines (CU1 and CU2) from embryos with an irreversible loss of integrated organismic function. In addition, we analyzed retrospective data of morphological prog
Externí odkaz:
https://doaj.org/article/5c3c130cebf24fc89935f6afa2c9b3dc
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2511 (2008)
The determination of left/right body axis during early embryogenesis sets up a developmental cascade that coordinates the development of the viscera and is essential to the correct placement and alignment of organ systems and vasculature. Defective l
Externí odkaz:
https://doaj.org/article/1c47fd41bc1d48c9bb6a6d85b7852d62