Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Virginia De Cesare"'
Autor:
Virginia De Cesare
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The attachment of ubiquitin to a substrate (ubiquitination or ubiquitylation) impacts its lifetime and regulates its function within the cell. Several classes of enzymes oversee the attachment of ubiquitin to the substrate: an E1 activating enzyme th
Externí odkaz:
https://doaj.org/article/21821e9a920848eab6507ea989c3ab7f
Autor:
Nicolas Huguenin-Dezot, Virginia De Cesare, Julien Peltier, Axel Knebel, Yosua Adi Kristaryianto, Daniel T. Rogerson, Yogesh Kulathu, Matthias Trost, Jason W. Chin
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 1180-1193 (2016)
Ubiquitin is post-translationally modified by phosphorylation at several sites, but the consequences of these modifications are largely unknown. Here, we synthesize multi-milligram quantities of ubiquitin phosphorylated at serine 20, serine 57, and s
Externí odkaz:
https://doaj.org/article/b5b139d187af49c2bc7b15568d7770ec
Autor:
Francesca R Cianfanelli, Juliana Alcoforado Diniz, Manman Guo, Virginia De Cesare, Matthias Trost, Sarah J Coulthurst
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005735 (2016)
The Type VI secretion system (T6SS) is widespread among bacterial pathogens and acts as an effective weapon against competitor bacteria and eukaryotic hosts by delivering toxic effector proteins directly into target cells. The T6SS utilises a bacteri
Externí odkaz:
https://doaj.org/article/84b3a553f9f54121bfb3db3f0884dabf
Autor:
Syed Arif Abdul Rehman, Elena Di Nisio, Chiara Cazzaniga, Odetta Antico, Axel Knebel, Clare Johnson, Frederic Lamoliatte, Rodolfo Negri, Miratul Muqit MK, Virginia De Cesare
E2 conjugating enzymes (E2s) play a central role in the enzymatic cascade that leads to the attachment of ubiquitin to a substrate. This process, termed ubiquitylation is fundamental for maintaining cellular homeostasis and impacts almost all cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5213529c293d7dae87454baf4c9f7290
https://doi.org/10.1101/2023.03.05.531151
https://doi.org/10.1101/2023.03.05.531151
Autor:
Sven M. Lange, Matthew R. McFarland, Frederic Lamoliatte, Dominika Kwaśna, Linnan Shen, Iona Wallace, Isobel Cole, Lee A. Armstrong, Axel Knebel, Clare Johnson, Virginia De Cesare, Yogesh Kulathu
Branched ubiquitin (Ub) chains make up a significant proportion of Ub polymers in human cells and are formed when two or more sites on a single Ub molecule are modified with Ub creating bifurcated architectures. Despite their abundance, we have a poo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e35913596d7c4ef61fc79481ed7099a7
https://doi.org/10.1101/2023.01.10.523363
https://doi.org/10.1101/2023.01.10.523363
Autor:
Virginia De Cesare, Paul Davies
Publikováno v:
Methods in Molecular Biology ISBN: 9781071628027
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::384f81236dbfe375142da6ce0d8a4d68
https://doi.org/10.1007/978-1-0716-2803-4_8
https://doi.org/10.1007/978-1-0716-2803-4_8
Autor:
Virginia, De Cesare, Paul, Davies
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2591
Ubiquitylation (or ubiquitination) is the reversible conjugation of a 76-amino-acid polypeptide (ubiquitin) to a target protein to modulate various biological processes. Deubiquitylating enzymes (DUBs) are a class of enzymes that specifically remove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c3090ecdfd0e3ccabba355b07c5c7c3
https://pubmed.ncbi.nlm.nih.gov/36350546
https://pubmed.ncbi.nlm.nih.gov/36350546
Autor:
Andreas Haag, Beatriz Rapun-Araiz, Virginia De Cesare, Pedro Dorado-Morales, José Penadés, Iñigo Lasa
Publikováno v:
Access Microbiology. 4
In bacteria, adaptation to changes in the environment is mainly controlled through two-component signal transduction systems (TCSs). Most bacteria contain dozens of TCSs, each of them responsible for sensing a different range of signals and controlli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::359c86a9fc8b8b79481d2e2bbddf89d7
https://doi.org/10.1099/acmi.ac2021.po0030
https://doi.org/10.1099/acmi.ac2021.po0030
Autor:
Ryan Traynor, Jennifer Moran, Michael Stevens, Axel Knebel, Bahareh Behrouz, Kalpana Merchant, C. James Hastie, Paul Davies, Miratul M. K. Muqit, Virginia De Cesare
Parkinson’s disease (PD) is a progressive neurological disorder that manifests clinically as alterations in movement (bradykinesia, postural instability, loss of balance, and resting tremors) as well as multiple non-motor symptoms including but not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860152ff160f8865fe516b08cc35f28b
https://doi.org/10.1101/2022.03.04.482851
https://doi.org/10.1101/2022.03.04.482851
Autor:
Virginia De Cesare, Ryan Traynor, Axel Knebel, C. James Hastie, Paul Davies, Hilary McLauchlan, Matthias Trost, Jennifer Moran, Maria Stella Ritorto
Publikováno v:
Nature Protocols. 15:4034-4057
Deubiquitylating enzymes (DUBs) play a vital role in the ubiquitin pathway by editing or removing ubiquitin from their substrate. As breakthroughs within the ubiquitin field continue to highlight the potential of deubiquitylating enzymes as drug targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba36523dc779cadbfa7437b93f233f8d
https://doi.org/10.1038/s41596-020-00405-0
https://doi.org/10.1038/s41596-020-00405-0