Zobrazeno 1 - 10
of 593
pro vyhledávání: '"Virginia B, Kraus"'
Autor:
Megan L. Libke, Daniel J. Cunningham, Bridgette D. Furman, John S. Yi, Jonathan M. Brunger, Virginia B. Kraus, Farshid Guilak, Amy L. McNulty, Steven A. Olson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Although various joint injuries result in post-traumatic osteoarthritis (PTOA), differences in chondrocyte response to specific injuries, such as blunt compression or fracture, are unclear. Furthermore, the role of underlying joint inflammat
Externí odkaz:
https://doaj.org/article/032f9d701d224ecab5bbd0cf5939dc05
Autor:
Shirley P. Yu, Leticia A. Deveza, Virginia B. Kraus, Morten Karsdal, Anne-Christine Bay-Jensen, Jamie E. Collins, Ali Guermazi, Frank W. Roemer, Christoph Ladel, Venkatesha Bhagavath, David J. Hunter
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-13 (2024)
Abstract Background To assess the prognostic value of short-term change in biochemical markers as it relates to bone marrow lesions (BMLs) on MRI in knee osteoarthritis (OA) over 24 months and, furthermore, to assess the relationship between biochemi
Externí odkaz:
https://doaj.org/article/66a88f0b88a841a7a733440fa117c61f
Autor:
Akshay Bareja, David E. Lee, Tricia Ho, Greg Waitt, Lauren H. McKay, Sarah A. Hannou, Melissa C. Orenduff, Kristen M. McGreevy, Alexandra Binder, Calen P. Ryan, Erik J. Soderblom, Daniel W. Belsky, Luigi Ferrucci, Jayanta Kumar Das, Nirad Banskota, Virginia B. Kraus, Janet L. Huebner, William E. Kraus, Kim M. Huffman, Gurpreet S. Baht, Steve Horvath, Robert J. Parmer, Lindsey A. Miles, James P. White
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113881- (2024)
Summary: An intriguing effect of short-term caloric restriction (CR) is the expansion of certain stem cell populations, including muscle stem cells (satellite cells), which facilitate an accelerated regenerative program after injury. Here, we utilize
Externí odkaz:
https://doaj.org/article/427aacba1e9c45278727a51ef1f744a6
Autor:
Yao Fu, Albert Batushansky, Michael Kinter, Janet L. Huebner, Virginia B. Kraus, Timothy M. Griffin
Publikováno v:
JBMR Plus, Vol 7, Iss 7, Pp n/a-n/a (2023)
ABSTRACT Leptin is a proinflammatory adipokine that contributes to obesity‐associated osteoarthritis (OA), especially in women. However, the extent to which leptin causes knee OA separate from the effect of increased body weight is not clear. We hy
Externí odkaz:
https://doaj.org/article/aa1cc937840a407a886dca46ed902848
Autor:
Louie C. Alexander, Grant McHorse, Janet L. Huebner, Anne-Christine Bay-Jensen, Morten A. Karsdal, Virginia B. Kraus
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-9 (2021)
Abstract Objective To compare C-reactive protein (CRP) and matrix metalloproteinase-generated neoepitope of CRP (CRPM) as biomarkers of inflammation and radiographic severity in patients with knee osteoarthritis. Methods Participants with symptomatic
Externí odkaz:
https://doaj.org/article/59e130860e7b4ba885306f3c4a7fb3d7
Autor:
Adam P. Goode, David Hu, Steven Z. George, Todd A. Schwartz, Virginia B. Kraus, Janet L. Huebner, Rebecca J. Cleveland, Kenneth A. Taylor, Joanne M. Jordan, Yvonne M. Golightly
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 4, Iss 3, Pp 100270- (2022)
Objective: Describe the association between biomarkers and lumbar spine degeneration (vertebral osteophytes [OST], facet joint osteoarthritis [FOA], and disc space narrowing [DSN]), for persons with and without low back pain (LBP) and determine wheth
Externí odkaz:
https://doaj.org/article/dbf4880876a1468590395f85fb58089b
Autor:
Christopher G Vann, Xin Zhang, Alastair Khodabukus, Melissa C. Orenduff, Yu-Hsiu Chen, David L. Corcoran, George A. Truskey, Nenad Bursac, Virginia B. Kraus
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Exercise affects the expression of microRNAs (miR/s) and muscle-derived extracellular vesicles (EVs). To evaluate sarcoplasmic and secreted miR expression in human skeletal muscle in response to exercise-mimetic contractile activity, we utilized a th
Externí odkaz:
https://doaj.org/article/01b3dc9dd88a468698e95c74c8051b9e
Autor:
Yunyun Luo, Jonathan Samuels, Svetlana Krasnokutsky, Inger Byrjalsen, Virginia B. Kraus, Yi He, Morten A. Karsdal, Steven B. Abramson, Mukundan Attur, Anne C. Bay-Jensen
Publikováno v:
Journal of Orthopaedics and Traumatology, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background Osteoarthritis (OA) is a disease with multiple endotypes. A hallmark of OA is loss of cartilage; however, it is evident that the rate of cartilage loss differs among patients, which may partly be attributed to differential capacit
Externí odkaz:
https://doaj.org/article/fe780c80254c4b1aad37ba8138ac360d
Autor:
Mukundan Attur, Svetlana Krasnokutsky, Hua Zhou, Jonathan Samuels, Gregory Chang, Jenny Bencardino, Pamela Rosenthal, Leon Rybak, Janet L. Huebner, Virginia B. Kraus, Steven B. Abramson
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-17 (2020)
Abstract Objective Predictive biomarkers of progression in knee osteoarthritis are sought to enable clinical trials of structure-modifying drugs. A peripheral blood leukocyte (PBL) inflammatory gene signature, MRI-based bone marrow lesions (BML) and
Externí odkaz:
https://doaj.org/article/609d3b655b50445fa3b8c11215d798ff
Autor:
Kelly A. Kimmerling, Sara J. Oswald, Janet L. Huebner, Dianne Little, Virginia B. Kraus, Jing X. Kang, Chia-Lung Wu, Farshid Guilak
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-10 (2020)
Abstract Background Dietary fatty acid (FA) content has been shown to influence the development of post-traumatic osteoarthritis (PTOA) in obesity. We used the fat-1 transgenic mouse to examine the hypothesis that endogenous reduction of ω-6 to ω-3
Externí odkaz:
https://doaj.org/article/37d54ee769984a20a71f14b945b7f49b