Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Virginia Andreotti"'
Autor:
Vera V. Grinkevich, Aparna Vema, Karin Fawkner, Natalia Issaeva, Virginia Andreotti, Eleanor R. Dickinson, Elisabeth Hedström, Clemens Spinnler, Alberto Inga, Lars-Gunnar Larsson, Anders Karlén, Margareta Wilhelm, Perdita E. Barran, Andrei L. Okorokov, Galina Selivanova, Joanna E. Zawacka-Pankau
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Restoration of the p53 tumor suppressor for personalised cancer therapy is a promising treatment strategy. However, several high-affinity MDM2 inhibitors have shown substantial side effects in clinical trials. Thus, elucidation of the molecular mecha
Externí odkaz:
https://doaj.org/article/6e3200658e124c519165fca58876e250
Autor:
Irene Vanni, Milena Casula, Lorenza Pastorino, Antonella Manca, Bruna Dalmasso, Virginia Andreotti, Marina Pisano, Maria Colombino, Italian Association for Cancer Research (AIRC) Study Group, Ulrich Pfeffer, Enrica Teresa Tanda, Carla Rozzo, Panagiotis Paliogiannis, Antonio Cossu, Paola Ghiorzo, Giuseppe Palmieri, for the Italian Melanoma Intergroup (IMI)
Publikováno v:
Diagnostic Pathology, Vol 15, Iss 1, Pp 1-18 (2020)
Abstract Background Identification of somatic mutations in key oncogenes in melanoma is important to lead the effective and efficient use of personalized anticancer treatment. Conventional methods focus on few genes per run and, therefore, are unable
Externí odkaz:
https://doaj.org/article/69d423c7d1ab4b458a345ad25ac7c05f
Clinical, pathological and dermoscopic phenotype of MITF p.E318K carrier cutaneous melanoma patients
Autor:
Giulia Ciccarese, Bruna Dalmasso, William Bruno, Paola Queirolo, Lorenza Pastorino, Virginia Andreotti, Francesco Spagnolo, Enrica Tanda, Giovanni Ponti, Cesare Massone, Francesco Drago, Aurora Parodi, Giovanni Ghigliotti, Maria Antonietta Pizzichetta, Paola Ghiorzo, Italian Melanoma Intergroup (I.M.I.)
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-11 (2020)
Abstract Background The p.E318K variant of the Melanocyte Inducing Transcription Factor (MITF) has been implicated in genetic predisposition to melanoma as an intermediate penetrance allele. However, the impact of this variant on clinico-phenotypic,
Externí odkaz:
https://doaj.org/article/84506d9f98bb426ab3107f4dad94e00a
Autor:
Erika Bandini, Ilaria Cangini, Valentina Arcangeli, Mila Ravegnani, Virginia Andreotti, Giovanna Prisinzano, Lorenza Pastorino, Giovanni Martinelli, Fabio Falcini, Daniele Calistri, Valentina Zampiga, Rita Danesi
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Birt–Hogg–Dubé syndrome (BHDS) is a rare autosomal dominant inherited disorder caused by a mutation in folliculin (FLCN) gene transmitted via germline autosomal dominant pattern. Patients with this syndrome have an increased susceptibility to re
Externí odkaz:
https://doaj.org/article/1d148c0101d04f9e91aece46a508a586
Autor:
Irene Vanni, Enrica Teresa Tanda, Bruna Dalmasso, Lorenza Pastorino, Virginia Andreotti, William Bruno, Andrea Boutros, Francesco Spagnolo, Paola Ghiorzo
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Melanoma is one of the most aggressive tumors of the skin, and its incidence is growing worldwide. Historically considered a drug resistant disease, since 2011 the therapeutic landscape of melanoma has radically changed. Indeed, the improved knowledg
Externí odkaz:
https://doaj.org/article/86fb5a66b05a4456ad48a400c2734cc4
Autor:
Enrica Teresa Tanda, Irene Vanni, Andrea Boutros, Virginia Andreotti, William Bruno, Paola Ghiorzo, Francesco Spagnolo
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Incidence of melanoma has been constantly growing during the last decades. Although most of the new diagnoses are represented by thin melanomas, the number of melanoma-related deaths in 2018 was 60,712 worldwide (Global Cancer Observatory, 2019). Unt
Externí odkaz:
https://doaj.org/article/8feba6aadf664dc7a62467d26485dcd7
Autor:
Irene Vanni, Enrica Teresa Tanda, Francesco Spagnolo, Virginia Andreotti, William Bruno, Paola Ghiorzo
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
The incidence of melanoma, among the most lethal cancers, is widespread and increasing. Metastatic melanoma has a poor prognosis, representing about 90% of skin cancer mortality. The increased knowledge of tumor biology and the greater understanding
Externí odkaz:
https://doaj.org/article/59b9b870b4c449a1985ad42236460aea
Autor:
William Bruno, Virginia Andreotti, Alessandra Bisio, Lorenza Pastorino, Giuseppe Fornarini, Stefania Sciallero, Giovanna Bianchi-Scarrà, Alberto Inga, Paola Ghiorzo
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189123 (2017)
CDKN2A coding region germline variants are associated with pancreatic adenocarcinoma (PC) susceptibility. Recently, we described functional germline 5'UTR CDKN2A variants from melanoma patients affecting the post-transcriptional regulation of p16INK4
Externí odkaz:
https://doaj.org/article/d2da31a7d05c4b75a4a4d1be1334c9ec
Autor:
Virginia Andreotti, Yari Ciribilli, Paola Monti, Alessandra Bisio, Mattia Lion, Jennifer Jordan, Gilberto Fronza, Paola Menichini, Michael A Resnick, Alberto Inga
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20643 (2011)
BackgroundThe p53 tumor suppressor, which is altered in most cancers, is a sequence-specific transcription factor that is able to modulate the expression of many target genes and influence a variety of cellular pathways. Inactivation of the p53 pathw
Externí odkaz:
https://doaj.org/article/2b8a025dfb6a4609b60f93c77cb8b8e6
Autor:
Yari Ciribilli, Virginia Andreotti, Daniel Menendez, Jan-Stephan Langen, Gilbert Schoenfelder, Michael A Resnick, Alberto Inga
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10236 (2010)
BackgroundRecently, we established that a C>T single nucleotide polymorphism (SNP) in the promoter of the VEGF receptor FLT1 gene generates a (1/2) site p53 response element (RE-T) that results in p53 responsiveness of the promoter. The transcription
Externí odkaz:
https://doaj.org/article/df11313559c046e288d78100b7f01f31