Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Virginia A. Zakian"'
Autor:
P. Daniela Garcia, Virginia A. Zakian
Publikováno v:
Microbial Cell, Vol 7, Iss 9, Pp 250-254 (2020)
RNase P, an RNA-protein complex, is essential for processing tRNAs. Three of the ten protein subunits of Saccharomyces cerevisiae RNase P (and a related complex, RNase MRP) co-purify with yeast telomerase, another RNA-protein complex. The three telom
Externí odkaz:
https://doaj.org/article/044800ec37254842a525a73e3ea2ee5e
Autor:
P. Daniela Garcia, Robert W. Leach, Gable M. Wadsworth, Krishna Choudhary, Hua Li, Sharon Aviran, Harold D. Kim, Virginia A. Zakian
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Pop1 and 6 are subunits of RNase P and RNase MRP, which process ribosomal and tRNAs. The authors show that when Pop1 and 6 are impaired, the telomerase subunit Est1 binds telomerase RNA at normal levels, but the binding is unstable. As a result, nucl
Externí odkaz:
https://doaj.org/article/60a84cb1852b4201965cf90b77707313
Autor:
Phong Lan Thao Tran, Thomas J. Pohl, Chi-Fu Chen, Angela Chan, Sebastian Pott, Virginia A. Zakian
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The budding yeast genome encodes two Pif1 family helicases, Pif1 and Rrm3, previously shown to have distinct functions in the maintenance of telomeres and other aspects of genome stability. Here the authors identify a role for Pif1 (and Rrm3) in prom
Externí odkaz:
https://doaj.org/article/2e8870bb59154364bb030628f649dba0
Publikováno v:
Cell Reports, Vol 6, Iss 2, Pp 346-356 (2014)
Human RecQ4 (hRecQ4) affects cancer and aging but is difficult to study because it is a fusion between a helicase and an essential replication factor. Budding yeast Hrq1 is homologous to the disease-linked helicase domain of RecQ4 and, like hRecQ4, i
Externí odkaz:
https://doaj.org/article/38ecaad018a8415c95738ac3bc92d11a
Autor:
Virginia A. Zakian, P. Daniela Garcia
Publikováno v:
Microbial Cell, Vol 7, Iss 9, Pp 250-254 (2020)
RNase P, an RNA-protein complex, is essential for processing tRNAs. Three of the ten protein subunits of Saccharomyces cerevisiae RNase P (and a related complex, RNase MRP) co-purify with yeast telomerase, another RNA-protein complex. The three telom
Publikováno v:
Genetics
Two common features of centromeres are their transcription into noncoding centromere RNAs (cen-RNAs) and their assembly into nucleosomes that contain a centromere-specific histone H3 (cenH3). Here, we show that Saccharomyces cerevisiae cen-RNA was pr
Publikováno v:
Genetics. 211:105-119
Pif1 family helicases are found in virtually all eukaryotes. Saccharomyces cerevisiae (Sc) encodes two Pif1 family helicases, ScPif1 and Rrm3. ScPif1 is multifunctional, required not only for maintenance of mitochondrial DNA but also for multiple dis
Autor:
Virginia A. Zakian, Chi Fu Chen, Phong Lan Thao Tran, Sebastian Pott, Thomas J. Pohl, Angela Chan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
Saccharomyces cerevisiae encodes two Pif1 family DNA helicases, Pif1 and Rrm3. Rrm3 promotes DNA replication past stable protein complexes at tRNA genes (tDNAs). We identify a new role for the Pif1 helicase: promotion of replication and suppression o
Autor:
Virginia A. Zakian, Thomas J. Pohl
Publikováno v:
DNA Repair (Amst)
An R-loop is a structure that forms when an RNA transcript stays bound to the DNA strand that encodes it and leaves the complementary strand exposed as a loop of single stranded DNA. R-loops accumulate when the processing of RNA transcripts is impair
Autor:
Carly L. Geronimo, Virginia A. Zakian
Publikováno v:
DNA Repair. 44:151-158
It is widely appreciated that the ends of linear DNA molecules cannot be fully replicated by the conventional replication apparatus. Less well known is that semi-conservative replication of telomeric DNA also presents problems for DNA replication. Th