Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Virginia, Takahashi"'
Autor:
Richard Stebbings, Christopher Jones, Peter Cotton, Gillian Armour, Shaun Maguire, Vicky Skellett, Chi-Man Tang, Joanne Goodman, Tyler Brady, Virginia Takahashi, Andrew Daunt, Jean-Martin Lapointe, Taylor S. Cohen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Severe COVID-19 can be associated with a prothrombotic state, increasing risk of morbidity and mortality. The SARS-CoV-2 spike glycoprotein is purported to directly promote platelet activation via the S1 subunit and is cleaved from host cells during
Externí odkaz:
https://doaj.org/article/c44929d2e5bd4c7cb0271ac7a867a93e
Autor:
Taylor S. Cohen, Michelle L. Boland, Brandon B. Boland, Virginia Takahashi, Andrey Tovchigrechko, Young Lee, Aimee D. Wilde, Mark J. Mazaitis, Omari Jones-Nelson, Christine Tkaczyk, Rajiv Raja, C. Kendall Stover, Bret R. Sellman
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2431-2441 (2018)
Summary: Clinical severity of Staphylococcus aureus respiratory infection correlates with alpha toxin (AT) expression. AT activates the NLRP3 inflammasome; deletion of Nlrp3, or AT neutralization, protects mice from lethal S. aureus pneumonia. We tes
Externí odkaz:
https://doaj.org/article/5ce6e8afcf3447d3a86bea39073220d6
Autor:
Kevin M Tuffy, Michael E Abram, Tiffany L Roe, Bahar Ahani, Tyler Brady, Nicolette Schuko, Lori Clarke, Carolina Caceres, Tara Kenny, Virginia Takahashi, Tianhui Zhang, David E Tabor, Gustavo H Kijak, Elizabeth J Kelly, Katie Streicher
Publikováno v:
Open Forum Infectious Diseases. 9
Background AZD7442 is a combination of extended–half-life SARS-CoV-2–neutralizing monoclonal antibodies (tixagevimab/cilgavimab) that bind to distinct epitopes on the SARS-CoV-2 spike protein. In the PROVENT study, a single 300 mg intramuscular d
Autor:
Richard, Stebbings, Christopher, Jones, Peter, Cotton, Gillian, Armour, Shaun, Maguire, Vicky, Skellett, Chi-Man, Tang, Joanne, Goodman, Tyler, Brady, Virginia, Takahashi, Andrew, Daunt, Jean-Martin, Lapointe, Taylor S, Cohen
Publikováno v:
Frontiers in immunology. 13
Severe COVID-19 can be associated with a prothrombotic state, increasing risk of morbidity and mortality. The SARS-CoV-2 spike glycoprotein is purported to directly promote platelet activation
Publikováno v:
Viruses, Vol 2, Iss 8, Pp 1734-1751 (2010)
Hepatitis C virus (HCV) infects over 130 million people worldwide and is a major cause of liver disease. No vaccine is available. Novel specific drugs for HCV are urgently required, since the standard-of-care treatment of pegylated interferon combine
Externí odkaz:
https://doaj.org/article/62991a4e0c244d5fa871a2d44ce03f2d
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32207 (2012)
Over 130 million people are infected chronically with hepatitis C virus (HCV), which, together with HBV, is the leading cause of liver disease. Novel small molecule inhibitors of Hepatitis C virus (HCV) are needed to complement or replace current tre
Externí odkaz:
https://doaj.org/article/f9f194d04056449b8948442dfd2ec619
Autor:
Langzhou Song, Valerian Nakaar, Uma Kavita, Albert Price, Jim Huleatt, Jie Tang, Andrea Jacobs, Ge Liu, Yan Huang, Priyanka Desai, Gail Maksymiuk, Virginia Takahashi, Scott Umlauf, Lucia Reiserova, Rodney Bell, Hong Li, Yi Zhang, William F McDonald, T J Powell, Lynda Tussey
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2257 (2008)
It is known that physical linkage of TLR ligands and vaccine antigens significantly enhances the immunopotency of the linked antigens. We have used this approach to generate novel influenza vaccines that fuse the globular head domain of the protectiv
Externí odkaz:
https://doaj.org/article/6ba45ece307a49aabda85d5795843da3
Autor:
Bret R. Sellman, Jessica Bonnell, Virginia Takahashi, Young Ho Lee, Raghothama Chaerkady, Sonja Hess, John J. Worthington, Rajiv Raja, Omari Jones-Nelson, Wen Yu, Taylor S. Cohen, C. Kendall Stover, Andrey Tovchigrechko, Mark A. Travis
Publikováno v:
Cohen, T S, Takahashi, V, Bonnell, J, Tovchigrechko, A, Chaerkady, R, Yu, W, Jones-Nelson, O, Lee, Y, Raja, R, Hess, S, Stover, C K, Worthington, J J, Travis, M A & Sellman, B R 2019, ' Staphylococcus aureus drives expansion of low-density neutrophils in diabetic mice ', The Journal of clinical investigation, vol. 130 . https://doi.org/10.1172/JCI126938
Diabetic individuals are at considerable risk for invasive infection by Staphylococcus aureus, however, the mechanisms underlying this enhanced susceptibility to infection are unclear. We observed increased mortality following i.v. S. aureus infectio
Publikováno v:
The Journal of General Virology
Hepatitis C virus (HCV) infects over 130 million people causing a worldwide epidemic of liver cirrhosis and hepatocellular-carcinoma. Because current HCV treatments are only partially effective, molecular mechanisms involved in HCV propagation are ac
Autor:
John A. Porco, John K. Snyder, Timothy P. Spicer, Aaron B. Beeler, Peter Hodder, Louis Scampavia, Arthur Donny Strosberg, Virginia Takahashi, Smitha Kota
Publikováno v:
ASSAY and Drug Development Technologies. 8:96-105
Binding of hepatitis C virus (HCV) RNA to core, the capsid protein, results in the formation of the nucleocapsid, the first step in the assembly of the viral particle. A novel assay was developed to discover small molecule inhibitors of core dimeriza