Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Virginia, Del Solar"'
Autor:
Yaron Marciano, Virginia del Solar, Nazia Nayeem, Dhwanit Dave, Jiye Son, María Contel, Rein V. Ulijn
Publikováno v:
Journal of the American Chemical Society.
We investigated the use of amphiphilic, protease-cleavable peptides as encapsulation moieties for hydrophobic metallodrugs, in order to enhance their bioavailability and consequent activity. Two hydrophobic, gold-containing anticancer agents varying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9f37e8fbd10c6580bfaa071c5fd63a
https://pubmed.ncbi.nlm.nih.gov/36542079
https://pubmed.ncbi.nlm.nih.gov/36542079
Autor:
Virginia del Solar, María Contel, Patrícia Appelt, Elsy El Khoury, Nazia Nayeem, Kirill Miachin, Daniela Buccella, Michelle C. Neary, Anton Khrystenko
Publikováno v:
Inorg Chem
The potential of ruthenium(II) compounds as an alternative to platinum-based clinical anticancer agents has been unveiled after extensive research for over 2 decades. As opposed to cisplatin, ruthenium(II) compounds have distinct mechanisms of action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f122ba2455f1e2779fd416f4b4e332d
https://europepmc.org/articles/PMC9912119/
https://europepmc.org/articles/PMC9912119/
Autor:
Virginia del Solar, Yusen Zhou, Rohitesh Gupta, Gabrielle Pawlowski, Khushi L. Matta, Sriram Neelamegham
Publikováno v:
Mol Omics
Small molecule monosaccharide analogs (e.g. 4F-GlcNAc, 4F-GalNAc) and acceptor decoys (e.g. ONAP, SNAP) are commonly used as metabolic glycoengineering tools to perturb molecular and cellular recognition processes. Azido-derivatized sugars (e.g. ManN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d31c754e8c1402f3eb9cf6abd11850
https://doi.org/10.1039/d0mo00023j
https://doi.org/10.1039/d0mo00023j
Autor:
Maria Contel, Jason Lewis, Patricia Manuela Ribeiro Pereira, Joshua Matthew, Natalia Curado Dianez, Virginia del Solar, Afruja Ahad, Hiwa Saeed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a72ac1fe172f9d7040b83c1fd137b6a4
https://doi.org/10.1021/scimeetings.1c00529
https://doi.org/10.1021/scimeetings.1c00529
Autor:
Aristotelis Antonopoulos, Alan E. Friedman, Monika Garg, Joseph T.Y. Lau, Xinheng Yu, Sriram Neelamegham, Shuen-Shiuan Wang, Virginia del Solar, Anne Dell, Mehrab Nasirikenari, Srinivasa-Gopalan Sampathkumar, Syed Meheboob Ahmed, Ahana Addya, Kavita Agarwal, Stuart M. Haslam
SUMMARYThere is a critical need to develop small molecule inhibitors of mucin-type O-linked glycosylation. The best known reagent currently is peracetylated benzyl-GalNAc, but it is only effective at millimolar concentrations. This manuscript demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07a96dae444101e4722b65caf19463a5
https://doi.org/10.1101/2020.12.13.422539
https://doi.org/10.1101/2020.12.13.422539
Autor:
G. Ekin Atilla-Gokcumen, Adolfo Quiñones-Lombraña, Virginia del Solar, Nasi Li, Javier G. Blanco
Publikováno v:
Biopharmaceutics & Drug Disposition. 39:315-318
Loxoprofen is an anti-inflammatory drug that requires bioactivation into the trans-OH metabolite to exert pharmacological activity. Evidence suggests that carbonyl reductase 1 (CBR1) is important during the bioactivation of loxoprofen. This study exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6d609335b2519b3417e9f0b4c6e2e65
https://doi.org/10.1002/bdd.2135
https://doi.org/10.1002/bdd.2135
Autor:
Shuen-Shiuan, Wang, Virginia Del, Solar, Xinheng, Yu, Aristotelis, Antonopoulos, Alan E, Friedman, Kavita, Agarwal, Monika, Garg, Syed Meheboob, Ahmed, Ahana, Addhya, Mehrab, Nasirikenari, Joseph T, Lau, Anne, Dell, Stuart M, Haslam, Srinivasa-Gopalan, Sampathkumar, Sriram, Neelamegham
Publikováno v:
Cell Chem Biol
There is a critical need to develop small molecule inhibitors of mucin-type O-linked glycosylation. The best-known reagent currently is benzyl-GalNAc, but it is only effective at millimolar concentrations. This manuscript demonstrates that Ac(5)GalNT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::478c013f7af2420ef457ea085bc37402
https://pubmed.ncbi.nlm.nih.gov/33609441
https://pubmed.ncbi.nlm.nih.gov/33609441
Autor:
Sriram Neelamegham, Virginia del Solar, Joseph T.Y. Lau, Xinheng Yu, Stuart M. Haslam, Ahana Addhya, Monika Garg, Anne Dell, Shuen-Shiuan Wang, Kavita Agarwal, Syed Meheboob Ahmed, Alan E. Friedman, Srinivasa-Gopalan Sampathkumar, Mehrab Nasirikenari, Aristotelis Antonopoulos
Publikováno v:
Cell Chemical Biology. 28:699-710.e5
Summary There is a critical need to develop small-molecule inhibitors of mucin-type O-linked glycosylation. The best-known reagent currently is benzyl-GalNAc, but it is effective only at millimolar concentrations. This article demonstrates that Ac5Ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4802e654e4e6fd566283626678025b7e
https://doi.org/10.1016/j.chembiol.2021.01.017
https://doi.org/10.1016/j.chembiol.2021.01.017
Autor:
Adolfo, Quiñones-Lombraña, Nasi, Li, Virginia, Del Solar, G Ekin, Atilla-Gokcumen, Javier G, Blanco
Publikováno v:
Biopharmaceuticsdrug disposition. 39(6)
Loxoprofen is an anti-inflammatory drug that requires bioactivation into the trans-OH metabolite to exert pharmacological activity. Evidence suggests that carbonyl reductase 1 (CBR1) is important during the bioactivation of loxoprofen. This study exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::53a474f82794346c7903a2e68dd6128d
https://pubmed.ncbi.nlm.nih.gov/29851133
https://pubmed.ncbi.nlm.nih.gov/29851133
Autor:
Darleny Y. Lizardo, Nasi Li, Virginia del Solar, Jerod J. Hurst, Christopher J. Brais, G. Ekin Atilla-Gokcumen
Publikováno v:
Chemistry & Biology. 22(12):1662-1670
Apoptosis is accompanied by distinct morphological changes at the plasma and organelle membrane level. Involvement of certain lipids in apoptosis has been established; however, we have limited understanding of the specific lipid structures that parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d5b31207e500f2b8e27c4d6d9d09a2