Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Virgil McCarthy"'
Autor:
Steven B. Kanner, Koc-Kan Ho, Michael V. McCullar, Marc O'Reilly, Kevin Wright, Scott Pearce, Xiao-Hui Liu, Michael Saunders, Yong Xu, Virgil McCarthy, Jihua Liu, David Vollmer, Anna Senina, Bai Luo, Jeremy Bullough, Adrianne Clifford, Rebecca N. Nix, Jason M. Foulks, K. Mark Parnell
Inactivation of the M2 form of pyruvate kinase (PKM2) in cancer cells is associated with increased tumorigenicity. To test the hypothesis that tumor growth may be inhibited through the PKM2 pathway, we generated a series of small-molecule PKM2 activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1681cbb614c99d18db4a719f8206e70
https://doi.org/10.1158/1535-7163.c.6536250
https://doi.org/10.1158/1535-7163.c.6536250
Supplementary Figure Legends from Pharmacologic Activation of PKM2 Slows Lung Tumor Xenograft Growth
Autor:
Steven B. Kanner, Koc-Kan Ho, Michael V. McCullar, Marc O'Reilly, Kevin Wright, Scott Pearce, Xiao-Hui Liu, Michael Saunders, Yong Xu, Virgil McCarthy, Jihua Liu, David Vollmer, Anna Senina, Bai Luo, Jeremy Bullough, Adrianne Clifford, Rebecca N. Nix, Jason M. Foulks, K. Mark Parnell
Supplementary Figure Legends - PDF file 41K, Legends for supplemental figures 1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06832d9dfe0e27d733354edca60423ca
https://doi.org/10.1158/1535-7163.22499760
https://doi.org/10.1158/1535-7163.22499760
Autor:
Steven B. Kanner, Koc-Kan Ho, Michael V. McCullar, Marc O'Reilly, Kevin Wright, Scott Pearce, Xiao-Hui Liu, Michael Saunders, Yong Xu, Virgil McCarthy, Jihua Liu, David Vollmer, Anna Senina, Bai Luo, Jeremy Bullough, Adrianne Clifford, Rebecca N. Nix, Jason M. Foulks, K. Mark Parnell
Supplementary Figures 1-4 - PDF file 294K, Supplementary Figure 1: PKM2 activation by screening hit XC-409; Supplementary Figure 2: Phosphorylation state of PKM2 at Tyr105 in cancer cell lines; supplementary Figure 3: Viability of a selection of lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a47597581c335365308895b32c34bb
https://doi.org/10.1158/1535-7163.22499757
https://doi.org/10.1158/1535-7163.22499757
Autor:
Steve Warner, C. Erec Stebbins, Bhasker Aavula, Adam J. Pelzek, Vincent A. Fischetti, Bhaskaran Shyam S, Michael V. McCullar, Chongtie Shi, Yong Xu, Jared Bearss, David J. Bearss, Allan R. Goldberg, Adrianne Clifford, Bradley Wolfe, Carissa Jones, David Vollmer, Hariprasad Vankayalapati, Virgil McCarthy, Raymond Schuch, Benjamin Brenning
We present the discovery and optimization of a novel series of inhibitors of bacterial UDP-N-acetylglucosamine 2-epimerase (called 2-epimerase in this paper). Starting from virtual screening hits, the activity of various inhibitory molecules was opti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5883c5adf918a7715891e5ca62340156
https://europepmc.org/articles/PMC3890692/
https://europepmc.org/articles/PMC3890692/
Autor:
Anna Senina, David Vollmer, Xiao-Hui Liu, Kevin Wright, Virgil McCarthy, Scott Pearce, Marc O'Reilly, Jason M. Foulks, K. Mark Parnell, Steven B. Kanner, Jihua Liu, Bai Luo, Jeremy Bullough, Koc-Kan Ho, Adrianne Clifford, Rebecca N. Nix, Michael Saunders, Yong Xu, Michael V. McCullar
Publikováno v:
Molecular cancer therapeutics. 12(8)
Inactivation of the M2 form of pyruvate kinase (PKM2) in cancer cells is associated with increased tumorigenicity. To test the hypothesis that tumor growth may be inhibited through the PKM2 pathway, we generated a series of small-molecule PKM2 activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b90d2d6c90d134e7e9c28f8e4947900
https://pubmed.ncbi.nlm.nih.gov/23720766
https://pubmed.ncbi.nlm.nih.gov/23720766
Autor:
Matthew Shaffer, Scott Pearce, Kan Ho, Yong Xu, Michael V. McCullar, Virgil McCarthy, David Vollmer, Xiao-Hui Liu, Jeremy Bullough, Adrianne Clifford, Bai Luo, Steven B. Kanner, Michael Saunders, Jihua Liu, Anna Senina, Jason M. Foulks, K. Mark Parnell
Publikováno v:
Molecular Cancer Therapeutics. 10:B143-B143
Tumor cells primarily utilize aerobic glycolysis, rather than oxidative phosphorylation, to metabolize glucose (the Warburg effect). The M2 splice form of pyruvate kinase (PKM2), the enzyme catalyzing the rate-limiting final step of glycolysis, is hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b0e403b2420f520327f44030c7feca6
https://doi.org/10.1158/1535-7163.targ-11-b143
https://doi.org/10.1158/1535-7163.targ-11-b143
Autor:
Steven L. Warner, Xiao-Hui Liu, Jared Bearss, Virgil McCarthy, Vollmer David, Colin Olsen, Hariprasad Vankayalapati, Eric Gourley, Carissa Jones, David J. Bearss
Publikováno v:
Molecular Cancer Therapeutics. 8:C206-C206
Activation of JAK2, an intracellular protein tyrosine kinase, is known to induce cell proliferation and apoptosis and it has been shown to be mediated by pro-inflammatory cytokines. JAK2 dysregulation is implicated in myeloproliferative disorders, so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9891af438902450bf2c5b0fc1b22f8c9
https://doi.org/10.1158/1535-7163.targ-09-c206
https://doi.org/10.1158/1535-7163.targ-09-c206
Autor:
Jason Scholl, Virgil McCarthy, Rajashree Joshi-Hangal, David Vollmer, Chongtie Shi, Paul Severson, Jared Bearss, Sanjeev Redkar, Roger Inloes, Carissa Jones, David J. Bearss
Publikováno v:
Molecular Cancer Therapeutics. 8:A190-A190
SGI-110 is a second generation hypomethylating agent being developed for treatment in myelodysplastic syndrome (MDS) and solid tumor malignancies. In previous work, SGI-110 has demonstrated potent in vivo activity in a number of tumor types, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68a0613100a2e1f9e4b5ece257e914ad
https://doi.org/10.1158/1535-7163.targ-09-a190
https://doi.org/10.1158/1535-7163.targ-09-a190
Autor:
Chongtie Shi, David Vollmer, Virgil McCarthy, Carissa Jones, Colin Olsen, Hariprasad Vankayalapati, Steven L. Warner, Xiao-Hui Liu, William Hewitt, Jared Bearss, Eric Gourley, Chunlin Tang, David J. Bearss
Publikováno v:
Molecular Cancer Therapeutics. 8:C199-C199
Epithelial and endothelial tyrosine kinase (Etk) is a nonreceptor tyrosine kinase that plays a central role in the proliferation, differentiation, apoptosis, and tumorigenicity of epithelial cells. Inhibition of Etk signaling can result in impaired c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0840655022b6cb8c58e14e4ec6d46f4b
https://doi.org/10.1158/1535-7163.targ-09-c199
https://doi.org/10.1158/1535-7163.targ-09-c199