Výsledky vyhledávání - "Virgil L. Styles"

Identification of an impurity in synthetically prepared GAZT: 4″,5″-dehydro-GAZT

Autor: Doug Minick, Gary E. Martin, Virgil L. Styles, Janet L. Rideout, Cecilia S. Koble, Robert L. Johnson, Ronald C. Crouch, William R. Hall, James Cichetti

Publikováno v: Journal of Heterocyclic Chemistry. 28:1795-1799

A minor impurity was recorded by hplc during the final purification of synthetically prepared samples of the 5′-0-glucuronide of azidothymidine (GAZT). Following isolation of a small quantity of this impurity by hplc, elucidation of the structure w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e3294b8b1f1a590afed6000547e832c
https://doi.org/10.1002/jhet.5570280724

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A CONVENIENT SYNTHESIS OF THIOFIBRATE ANALOGS FROM ARYL SULFONYL CHLORIDES

Autor: Eric E. Boros, Virgil L. Styles, Peter Brown, Istvan Kaldor

Publikováno v: Synthetic Communications. 31:505-510

An expedient synthesis of pharmacologically relevant thioisobutyric acid esters from aryl sulfonyl chlorides is described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58a2ca25c4c46ec68963d3fcc2e4155e
https://doi.org/10.1081/scc-100000575

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Preparation of fluorinated phenoxathiin dioxide monoamine oxidase-A inhibitors: Intramolecular radical substitution at sulfurversusthe mauthner synthesis

Autor: Morton Harfenist, Mark D. Reeves, Eric E. Boros, Virgil L. Styles, James L. Kelley, William R. Hall

Publikováno v: Journal of Heterocyclic Chemistry. 35:699-706

Five unique fluorinated analogs, 8a-c and 15a,b, of the monoamine oxidase-A inhibitor 3-iso-propoxyphenoxathiin 10,10-dioxide (II) were prepared via oxidation of the corresponding phenoxathiins 7 and 14. 3-Fluoro-7-isopropoxy- 7a, 2-fluoro-3-isopropo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc64781d397d7cf9a96b908793e3eb1c
https://doi.org/10.1002/jhet.5570350332

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Synthesis of 5-(4-substituted benzyl)-2,4-diaminoquinazolines as inhibitors ofcandida albicansdihydrofolate reductase

Autor: Robert L. Tansik, Sharon K. Rudolph, Christine M. Boytos, Virgil L. Styles, Joseph H. Chan, G. Erik Jagdmann

Publikováno v: Journal of Heterocyclic Chemistry. 32:1461-1465

Several 5-(4-substituted benzyl)-2,4-diaminoquinazolines were prepared as potentially selective inhibitors of Candida albicans dihydrofolate reductase. These compounds were synthesized by a novel route, which included as a key step the displacement o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a57b311d2226b1046ec5d462af4ec66
https://doi.org/10.1002/jhet.5570320508

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7-(2-fluorobenzyl)-4-(substituted)-7-H-imidazo[4,5-d−1,2,3-triazines and −7H-pyrazolo[3,4-d]-1,2,3-triazines. Synthesis and anticonvulsant activity

Autor: James L. Kelley, David Wilson, F. E. Soroko, Virgil L. Styles, Barrett R. Cooper

Publikováno v: Journal of Heterocyclic Chemistry. 32:1417-1421

The imidazo[4,5-d]-1,2,3-triazine and pyrazolo[3,4-d]-1,2,3-triazine analogues of the potent anticonvul-sant purine, BW 78U79 (9-(2-fluorobenzyl)-6-methylamino-9H-purine, 1), were synthesized and tested for anticonvulsant activity. The imidazo[4,5-d]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6add8bd6229efcb002873fc22829e07
https://doi.org/10.1002/jhet.5570320502

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ChemInform Abstract: Identification of an Impurity in Synthetically Prepared GAZT: 4′′,5′′- Dehydro-GAZT

Autor: Cecilia S. Koble, Doug Minick, James Cichetti, Gary E. Martin, Ronald C. Crouch, Janet L. Rideout, Virgil L. Styles, William R. Hall, Robert L. Johnson

Publikováno v: ChemInform. 23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b952faf19c95b81ba86eeb044322f81f
https://doi.org/10.1002/chin.199211257

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ChemInform Abstract: Synthesis and Anticonvulsant Activity of 3H-Imidazo(4,5-c)pyridazine, 1H-Imidazo(4,5-d)pyridazine and 1H-Benzimidazole Analogues of 9-(2- Fluorobenzyl)-6-methylamino-9H-purine

Autor: James L. Kelley, Barrett R. Cooper, F. E. Soroko, James B. Thompson, Virgil L. Styles

Publikováno v: ChemInform. 27

The 3H-imidazo[4,5-c]pyridazine, 1H-imidazo[4,5-d]pyridazine, and 1H-benzimidazole analogues of the potent anticonvulsant purine 9-(2-fluorobenzyl)-6-methylamino-9H-purine (1, 78U79) were synthesized and tested for anticonvulsant activity. The 3H-imi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecfbea94083396f94aae20eacc089e26
https://doi.org/10.1002/chin.199613163

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