Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Virendar K. Kaushik"'
Autor:
Mark Chaffin, Irinna Papangeli, Bridget Simonson, Amer-Denis Akkad, Matthew C. Hill, Alessandro Arduini, Stephen J. Fleming, Michelle Melanson, Sikander Hayat, Maria Kost-Alimova, Ondine Atwa, Jiangchuan Ye, Kenneth C. Bedi, Matthias Nahrendorf, Virendar K. Kaushik, Christian M. Stegmann, Kenneth B. Margulies, Nathan R. Tucker, Patrick T. Ellinor
Publikováno v:
Nature. 608:174-180
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3953303da37730099f0ab2b5ff9e6a36
https://doi.org/10.1038/s41586-022-04817-8
https://doi.org/10.1038/s41586-022-04817-8
Autor:
Bryan T. MacDonald, Nadine H. Elowe, Colin W. Garvie, Virendar K. Kaushik, Patrick T. Ellinor
Corin is a transmembrane tethered enzyme best known for processing the hormone atrial natriuretic peptide (ANP) in cardiomyocytes to control electrolyte balance and blood pressure. Loss of function mutations in Corin prevent ANP processing and lead t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f604ff35c2f23994f0e7148ee118f50f
https://doi.org/10.1101/2023.04.26.538495
https://doi.org/10.1101/2023.04.26.538495
Autor:
Matthew G. Rees, Lisa Brenan, Mariana do Carmo, Patrick Duggan, Besnik Bajrami, Michael Arciprete, Andrew Boghossian, Emma Vaimberg, Steven J. Ferrara, Timothy A. Lewis, Danny Rosenberg, Tenzin Sangpo, Jennifer A. Roth, Virendar K. Kaushik, Federica Piccioni, John G. Doench, David E. Root, Cory M. Johannessen
Publikováno v:
Nature Chemical Biology. 18:615-624
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ac7ee4182f44347d0a5bf923187d891
https://doi.org/10.1038/s41589-022-00996-7
https://doi.org/10.1038/s41589-022-00996-7
Autor:
Dale Porter, Alessandra Ianari, Merissa Brousseau, Patrick McCarren, Foxy P. Robinson, Adam Skepner, Virendar K. Kaushik, Kathleen M. Mulvaney, Arthur J. Campbell, Martin J Drysdale, Zachary Mullin-Bernstein, Brian J. McMillan, Robert Hilgraf, Ritu Singh, Matthew J. Ranaghan, Meghan O’Keefe, William R. Sellers, David C. McKinney, Jamie A. Moroco, Michael F. Mesleh, David E. Timm, Besnik Bajrami, Florence F. Wagner
Publikováno v:
J Med Chem
PRMT5 and its substrate adaptor proteins (SAPs), pICln and Riok1, are synthetic lethal dependencies in MTAP-deleted cancer cells. SAPs share a conserved PRMT5 binding motif (PBM) which mediates binding to a surface of PRMT5 distal to the catalytic si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2c09646bd9e9db576eb95fa59b4da5
https://doi.org/10.1021/acs.jmedchem.1c00507
https://doi.org/10.1021/acs.jmedchem.1c00507
Autor:
Sonia M Vallabh, Arthur J. Campbell, Jayme L. Dahlin, Michael F. Mesleh, Kong T. Nguyen, Dominick Casalena, S. Kirk Wright, Dmitry L. Usanov, Christopher T. Lemke, Jamie A. Moroco, Joshua R. Sacher, Andrew G. Reidenbach, Murugappan Sathappa, Om K. Shrestha, Eric Vallabh Minikel, Jenna B. Yehl, Douglas S. Auld, Stuart L. Schreiber, V.L. Rangel, Alix I. Chan, Rishi N. Shah, Maria Cristina Nonato, David R. Liu, Florence F. Wagner, Alison Leed, Virendar K. Kaushik
Publikováno v:
J Biol Chem
Prion disease is a rapidly progressive neurodegenerative disorder caused by misfolding and aggregation of the prion protein (PrP), and there are currently no therapeutic options. PrP ligands could theoretically antagonize prion formation by protectin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8fc34d169f5f23f5d3171c3a119372
https://doi.org/10.1074/jbc.ra120.014905
https://doi.org/10.1074/jbc.ra120.014905
Autor:
Taiji Mizoguchi, Bryan T MacDonald, Bidur Bhandary, Nicholas R Popp, Dylan Laprise, Alessandro Arduini, Daniel Lai, Qiuyu M Zhu, Yi Xing, Virendar K Kaushik, Sekar Kathiresan, Patrick T Ellinor
Publikováno v:
Circulation. 144
Background: Despite contemporary therapy, coronary artery disease (CAD) remains a leading cause of mortality. Genetic variants at ADAMTS7 have been associated with CAD and the loss of ADAMTS7 is protective for atherosclerosis. ADAMTS7 (a disintegrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cb9198568b6acf074ecdb460637fc06
https://doi.org/10.1161/circ.144.suppl_1.12121
https://doi.org/10.1161/circ.144.suppl_1.12121
Autor:
Minxian, Wang, Vivian S, Lee-Kim, Deepak S, Atri, Nadine H, Elowe, John, Yu, Colin W, Garvie, Hong-Hee, Won, Joseph E, Hadaya, Bryan T, MacDonald, Kevin, Trindade, Olle, Melander, Daniel J, Rader, Pradeep, Natarajan, Sekar, Kathiresan, Virendar K, Kaushik, Amit V, Khera, Rajat M, Gupta
Publikováno v:
Circ Genom Precis Med
BACKGROUND: Corin is a protease expressed in cardiomyocytes that plays a key role in salt handling and intravascular volume homeostasis via activation of natriuretic peptides. It is unknown if Corin loss-of-function is causally associated with risk o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::609b79810016a6379ab5ada9f4ba4595
https://pubmed.ncbi.nlm.nih.gov/34592835
https://pubmed.ncbi.nlm.nih.gov/34592835
Autor:
Daniel J. Rader, Sekar Kathiresan, Joseph E. Hadaya, Rajat M. Gupta, John Yu, Deepak Atri, Vivian S. Lee-Kim, Virendar K. Kaushik, Hong-Hee Won, Minxian Wang, Colin W. Garvie, Kevin Trindade, Amit Khera, Bryan T. MacDonald, Nadine H. Elowe, Pradeep Natarajan, Olle Melander
Publikováno v:
Circulation: Genomic and Precision Medicine. 14
Background: Corin is a protease expressed in cardiomyocytes that plays a key role in salt handling and intravascular volume homeostasis via activation of natriuretic peptides. It is unknown if Corin loss-of-function (LOF) is causally associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77cf011950cb03226e890012d1d7049c
https://doi.org/10.1161/circgen.121.003399
https://doi.org/10.1161/circgen.121.003399
Autor:
Nicholas R Popp, Patrick T. Ellinor, Qiuyu Martin Zhu, Yi Xing, Alessandro Arduini, Taiji Mizoguchi, Daniel Lai, Dylan Laprise, Virendar K. Kaushik, Sekar Kathiresan, Bryan T. MacDonald, Bidur Bhandary
Publikováno v:
Circ Res
Rationale: Despite contemporary therapy, coronary artery disease (CAD) remains a leading cause of mortality. Genetic variants at ADAMTS7 have been associated with CAD and the loss of ADAMTS7 (a disintegrin and metalloproteinase with thrombospondin mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3955d330c41dd2893ed411cbafb6269e
https://europepmc.org/articles/PMC8349873/
https://europepmc.org/articles/PMC8349873/
Publikováno v:
Proceedings of the National Academy of Sciences. 116:3546-3555
The mitochondrial uniporter is a Ca 2+ -channel complex resident within the organelle’s inner membrane. In mammalian cells the uniporter’s activity is regulated by Ca 2+ due to concerted action of MICU1 and MICU2, two paralogous, but functionally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e1e8ee366a2cbdfaaf491b76902cea
https://doi.org/10.1073/pnas.1817759116
https://doi.org/10.1073/pnas.1817759116