Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Viranga Tilakaratna"'
Autor:
Rawshan Choudhury, Nadhim Bayatti, Richard Scharff, Ewa Szula, Viranga Tilakaratna, Maja Søberg Udsen, Selina McHarg, Janet A. Askari, Martin J. Humphries, Paul N. Bishop, Simon J. Clark
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Retinal pigment epithelial (RPE) cells that underlie the neurosensory retina are essential for the maintenance of photoreceptor cells and hence vision. Interactions between the RPE and their basement membrane, i.e. the inner layer of Bruch
Externí odkaz:
https://doaj.org/article/744e5ccb41c64bcf9d0d0a1eaadb8a8c
Autor:
Valentina Cipriani, Laura Lorés-Motta, Fan He, Dina Fathalla, Viranga Tilakaratna, Selina McHarg, Nadhim Bayatti, İlhan E. Acar, Carel B. Hoyng, Sascha Fauser, Anthony T. Moore, John R. W. Yates, Eiko K. de Jong, B. Paul Morgan, Anneke I. den Hollander, Paul N. Bishop, Simon J. Clark
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
A locus on chromosome 1 encompassing the CFHR genes is highly associated with AMD risk. Here, Cipriani and colleagues investigate the role of CFHR4, encoding FHR-4, and demonstrate a relationship between AMD risk, circulating FHR-4 levels and genetic
Externí odkaz:
https://doaj.org/article/0b0f1261bc8d49669412ef574f2fe536
Autor:
Viranga Tilakaratna, Douda Bensasson
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 9, Pp 2919-2929 (2017)
Genetic admixture can provide material for populations to adapt to local environments, and this process has played a crucial role in the domestication of plants and animals. The model yeast, Saccharomyces cerevisiae, has been domesticated multiple ti
Externí odkaz:
https://doaj.org/article/ad437557031240249d076ced8c218ac9
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Age-related macular degeneration (AMD) is the leading cause of blindness in the western world and affects nearly 200 million people globally. Local inflammation driven by complement system dysregulation is currently a therapeutic target. Bruch’s me
Externí odkaz:
https://doaj.org/article/f46c55d2b45948899b31df7333679f27
Autor:
Alex Langford-Smith, Viranga Tilakaratna, Paul R Lythgoe, Simon J Clark, Paul N Bishop, Anthony J Day
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147576 (2016)
Age-related cataract formation is the primary cause of blindness worldwide and although treatable by surgical removal of the lens the majority of sufferers have neither the finances nor access to the medical facilities required. Therefore, a better u
Externí odkaz:
https://doaj.org/article/697f9e7192c34982aa456dc55c930c1b
Autor:
Nicholas J. Turner, Aled D. Roberts, Itziar Peñafiel, Nigel S. Scrutton, Viranga Tilakaratna, Sebastian C. Cosgrove, William Finnigan, Karl A. P. Payne
Publikováno v:
Green Chemistry. 23:4716-4732
The development of cost-effective and green enzyme immobilisation techniques will facilitate the adoption of continuous flow biocatalysis (CFB) by industry and academia. In this work, a relatively mild sulfite pulping process was employed to remove l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2ff833e3925c6fce458535c0fa4d23
https://doi.org/10.1039/d1gc01008e
https://doi.org/10.1039/d1gc01008e
Autor:
Martin J. Humphries, Paul N. Bishop, Nadhim Bayatti, Maja Søberg Udsen, Rawshan Choudhury, Viranga Tilakaratna, Selina McHarg, Richard Scharff, Ewa Szula, Simon J. Clark, Janet A. Askari
Publikováno v:
Scientific Reports
Choudhury, R, Bayatti, N, Scharff, R, Szula, E, Tilakaratna, V, Udsen, M, Mcharg, S, Askari, J, Humphries, M J, Bishop, P & Clark, S 2021, ' FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress ', Scientific Reports, vol. 11, no. 1, 14175 . https://doi.org/10.1038/s41598-021-93708-5
Choudhury, R, Bayatti, N, Scharff, R, Szula, E, Tilakaratna, V, Udsen, M S, McHarg, S, Askari, J A, Humphries, M J, Bishop, P N & Clark, S J 2021, ' FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress ', Scientific Reports, vol. 11, 14175 . https://doi.org/10.1038/s41598-021-93708-5
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Choudhury, R, Bayatti, N, Scharff, R, Szula, E, Tilakaratna, V, Udsen, M, Mcharg, S, Askari, J, Humphries, M J, Bishop, P & Clark, S 2021, ' FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress ', Scientific Reports, vol. 11, no. 1, 14175 . https://doi.org/10.1038/s41598-021-93708-5
Choudhury, R, Bayatti, N, Scharff, R, Szula, E, Tilakaratna, V, Udsen, M S, McHarg, S, Askari, J A, Humphries, M J, Bishop, P N & Clark, S J 2021, ' FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress ', Scientific Reports, vol. 11, 14175 . https://doi.org/10.1038/s41598-021-93708-5
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Retinal pigment epithelial (RPE) cells that underlie the neurosensory retina are essential for the maintenance of photoreceptor cells and hence vision. Interactions between the RPE and their basement membrane, i.e. the inner layer of Bruch’s membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd44c6c515f5cf3e410767874f2acb8
https://pubmed.ncbi.nlm.nih.gov/34239032
https://pubmed.ncbi.nlm.nih.gov/34239032
Autor:
Fan He, Eiko K. de Jong, Laura Lorés-Motta, John R.W. Yates, Sascha Fauser, Anthony T. Moore, B. Paul Morgan, Nadhim Bayatti, Selina McHarg, Ilhan Erkin Acar, Simon J. Clark, Anneke I. den Hollander, Carel B. Hoyng, Paul N. Bishop, Valentina Cipriani, Dina Fathalla, Viranga Tilakaratna
Publikováno v:
Nature Communications
Nature Communications, 11
Cipriani, V, Lores-Motta, L, He, F, Fathalla, D, Tilakaratna, V, Mcharg, S, Bayatti, N, Acar, I E, Hyong, C B, Fauser, S, Moore, A T, Yates, J R W, de Jong, E K, Morgan, B P, den Hollander, A I, Bishop, P & Clark, S 2020, ' Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration ', Nature Communications, vol. 11, no. 1, 778, pp. 778 . https://doi.org/10.1038/s41467-020-14499-3
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, vol 11, iss 1
Nature Communications, 11, 1
Nature Communications, 11
Cipriani, V, Lores-Motta, L, He, F, Fathalla, D, Tilakaratna, V, Mcharg, S, Bayatti, N, Acar, I E, Hyong, C B, Fauser, S, Moore, A T, Yates, J R W, de Jong, E K, Morgan, B P, den Hollander, A I, Bishop, P & Clark, S 2020, ' Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration ', Nature Communications, vol. 11, no. 1, 778, pp. 778 . https://doi.org/10.1038/s41467-020-14499-3
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, vol 11, iss 1
Nature Communications, 11, 1
Age-related macular degeneration (AMD) is a leading cause of blindness. Genetic variants at the chromosome 1q31.3 encompassing the complement factor H (CFH, FH) and CFH related genes (CFHR1-5) are major determinants of AMD susceptibility, but their m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cc8d9a95cdbfac23be641800dac97a
http://europepmc.org/articles/PMC7005798
http://europepmc.org/articles/PMC7005798
Autor:
Tobias M. Hedison, Robin Hoeven, Balaji Lakavath, Muralidharan Shanmugam, Nigel S. Scrutton, Derren J. Heyes, Michiyo Sakuma, Viranga Tilakaratna
Publikováno v:
Lakavath, B, Hedison, T, Heyes, D, Shanmugam, M, Sakuma, M, Hoeven, R, Tilakaratna, V & Scrutton, N 2020, ' Radical-based photoinactivation of fatty acid photodecarboxylases ', Analytical Biochemistry|Anal Biochem, vol. 600, 113749 . https://doi.org/10.1016/j.ab.2020.113749
Fatty acid photodecarboxylases (FAP) are a recently discovered family of FAD-containing, light-activated enzymes, which convert fatty acids to n-alkanes/alkenes with potential applications in the manufacture of fine and speciality chemicals and fuels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992109bcf262d88b9321ee769b2fa976
https://doi.org/10.1016/j.ab.2020.113749
https://doi.org/10.1016/j.ab.2020.113749
Autor:
Markus A. Loeven, Anthony J. Day, Lambert P. van den Heuvel, Carolien M. S. Schophuizen, Viranga Tilakaratna, Johan van der Vlag, Jasper J. van Gemst, B. Jeroen Klevering
Publikováno v:
Investigative Ophthalmology and Visual Science, 59, 722-730
Investigative Ophthalmology and Visual Science, 59, 2, pp. 722-730
Loeven, M A, van Gemst, J J, Schophuizen, C M S, Tilakaratna, V, van Den Heuvel, L P, Day, A J, Klevering, B J & van Der Vlag, J 2018, ' A novel choroidal endothelial cell line has a decreased affinity for the age-related macular degeneration– associated complement factor h variant 402h ', Investigative Ophthalmology and Visual Science, vol. 59, no. 2, pp. 722-730 . https://doi.org/10.1167/iovs.IOVS-17-22893
Investigative Ophthalmology and Visual Science, 59, 2, pp. 722-730
Loeven, M A, van Gemst, J J, Schophuizen, C M S, Tilakaratna, V, van Den Heuvel, L P, Day, A J, Klevering, B J & van Der Vlag, J 2018, ' A novel choroidal endothelial cell line has a decreased affinity for the age-related macular degeneration– associated complement factor h variant 402h ', Investigative Ophthalmology and Visual Science, vol. 59, no. 2, pp. 722-730 . https://doi.org/10.1167/iovs.IOVS-17-22893
PURPOSE. Choroidal endothelial cells play a central role in the pathogenesis of age-related macular degeneration (AMD). Protocols for isolating primary choroidal endothelial cells have been described but require access to human donor eyes, which is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e6fac791457ef9244437821ff8d94d
http://hdl.handle.net/2066/187848
http://hdl.handle.net/2066/187848
