Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Viral terminase complex"'
Autor:
Kori Daniels, Amber Clemmons
Publikováno v:
Journal of the Advanced Practitioner in Oncology
Cytomegalovirus (CMV) is a double-stranded DNA virus that infects (seropositive on screening) more than half of adults by age 40. However, reactivation of detectable viral load (CMV reactivation) typically occurs only in immunocompromised patients. N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44aaa3837522af325644b8d752433d6
http://europepmc.org/articles/PMC7517777
http://europepmc.org/articles/PMC7517777
Autor:
Hanieh Ghassabian, Beatrice Mercorelli, Gualtiero Alvisi, Arianna Loregian, Martina Timmoneri, Giorgio Palu, Federico Falchi
Publikováno v:
Viruses
Volume 13
Issue 5
Viruses, Vol 13, Iss 941, p 941 (2021)
Volume 13
Issue 5
Viruses, Vol 13, Iss 941, p 941 (2021)
Human cytomegalovirus (HCMV) is a leading cause of severe diseases in immunocompromised individuals, including AIDS patients and transplant recipients, and in congenitally infected newborns. The utility of available drugs is limited by poor bioavaila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e776359a208a40ce9669483071fe306
Autor:
Arianna Loregian, Gualtiero Alvisi, Federico Falchi, Hanieh Ghassabian, Veronica Di Antonio, Martina Timmoneri, Giorgio Palù, Beatrice Mercorelli
Human cytomegalovirus (HCMV) is a leading cause of severe diseases in immunocompromised individuals, including AIDS and transplanted patients, and in congenitally infected newborns. Despite the availability of several antiviral drugs, their utility i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f3dc028c3440659d4c5a04042fb135
Autor:
Atul Humar, Shahid Husain, Victor H Ferreira, Pakpoom Phoompoung, Deepali Kumar, Auro Viswabandya, Jussi Tikkanen
Publikováno v:
Transplantation. 104(2)
Background Letermovir, a new viral terminase complex inhibitor, has been approved for the prevention of cytomegalovirus (CMV) infection in hematopoietic stem cell transplant patients. However, data on the efficacy and safety of letermovir for the tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a8124ef63b04c67b9e1554eff85269
https://pubmed.ncbi.nlm.nih.gov/32000236
https://pubmed.ncbi.nlm.nih.gov/32000236
Publikováno v:
BMC Infectious Diseases
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-5 (2019)
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-5 (2019)
Background The compound letermovir (LMV) has recently been approved for the prophylaxis of cytomegalovirus (CMV) infection and disease in adult CMV seropositive recipients of an allogeneic hematopoietic stem cell transplant. LMV inhibits CMV replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae2898741e6d14db6d7dab0d9a9adcd7
https://doi.org/10.1186/s12879-019-4016-1
https://doi.org/10.1186/s12879-019-4016-1
Publikováno v:
Future microbiology. 14
Cytomegalovirus (CMV) manifestations remain important complications after allogeneic hematopoietic stem cell transplantation (HSCT), even in the current era. Unfortunately, available anti-CMV agents, mainly viral polymerase inhibitors, have a substan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d679386cd9d410dd72f24b466664c7b2
https://pubmed.ncbi.nlm.nih.gov/30644320
https://pubmed.ncbi.nlm.nih.gov/30644320
Autor:
Guy Boivin, Jocelyne Piret
Publikováno v:
Antiviral research. 163
The prevention and treatment of human cytomegalovirus (HCMV) infections is based on the use of antiviral agents that currently target the viral DNA polymerase and that may cause serious side effects. The search for novel inhibitors against HCMV infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81675bafc4371a3c43681b71225a838
https://pubmed.ncbi.nlm.nih.gov/30690043
https://pubmed.ncbi.nlm.nih.gov/30690043
Publikováno v:
Biology of Blood and Marrow Transplantation. 25:S344-S345
Background Antiviral resistance to human cytomegalovirus (CMV) is an important complication for immunocompromised patients on prolonged antiviral regimens, and CMV remains the most clinically significant infection following allogeneic hematopoietic-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97557dcc1e028f771ecc641224ef622f
https://doi.org/10.1016/j.bbmt.2018.12.558
https://doi.org/10.1016/j.bbmt.2018.12.558
Autor:
McNulty, Reginald, Lokareddy, Ravi Kumar, Roy, Ankoor, Yang, Yang, Lander, Gabriel C., Heck, Albert J R, Johnson, John E., Cingolani, Gino, Sub Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics
Publikováno v:
Journal of Molecular Biology, 427(20), 3285. Academic Press Inc.
Packaging of viral genomes inside empty procapsids is driven by a powerful ATP-hydrolyzing motor, formed in many double-stranded DNA viruses by a complex of a small terminase (S-terminase) subunit and a large terminase (L-terminase) subunit, transien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ca0a8de0fb1543c0783edc43ee1665
https://doi.org/10.1016/j.jmb.2015.08.013
https://doi.org/10.1016/j.jmb.2015.08.013
Publikováno v:
Infection and Drug Resistance
Infection with cytomegalovirus is prevalent in immunosuppressed patients. In solid organ transplant and hematopoietic stem cell transplant recipients, cytomegalovirus infection is associated with high morbidity and preventable mortality. Prevention a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0fc9180804ce05b5e803245b1d07b8
http://europepmc.org/articles/PMC4531042
http://europepmc.org/articles/PMC4531042