Zobrazeno 1 - 10
of 22 770
pro vyhledávání: '"Viral Vector"'
Autor:
Wuh-Liang Hwu
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-13 (2024)
Abstract Gene therapy has made considerable strides in recent years. More than 4000 protein-coding genes have been implicated in more than 6000 genetic diseases; next-generation sequencing has dramatically revolutionized the diagnosis of genetic dise
Externí odkaz:
https://doaj.org/article/c3989bfb13684df09009458ecb06391b
Publikováno v:
International Journal of General Medicine, Vol Volume 17, Pp 3349-3360 (2024)
Abdallah Damin Abukhalil,* Raya Riyad Abushehadeh,* Sireen Sultan Shatat,* Ni’meh Al-Shami,* Hani A Naseef,* Hosniyeh Ladadweh,* Raed Madia* Faculty of Pharmacy, Nursing and Health Professions, Birzeit University, Birzei
Externí odkaz:
https://doaj.org/article/0cd4e45b7ff743c0a7fb1da90159c0dd
Autor:
Joshua Tworig, Francis Grafton, Kaylin Fisher, Markus Hörer, Christopher A. Reid, Mohammad A. Mandegar
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101384- (2024)
Recombinant adeno-associated virus (rAAV) is a widely used viral vector for gene therapy. However, these vectors have limited availability due to manufacturing challenges with productivity and quality. These challenges can be addressed by better unde
Externí odkaz:
https://doaj.org/article/66c2059588f943ce9337e481e3bd442c
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101376- (2024)
The replication-defective adeno-associated virus (AAV) is extensively utilized as a research tool or vector for gene therapy. The production process of AAV remains intricate, expensive, and mechanistically underexplored. With the aim of enhancing AAV
Externí odkaz:
https://doaj.org/article/243fe99486504bcaa78bf85bc85b05ea
Autor:
Annabelle Pfeifle, Wanyue Zhang, Jingxin Cao, Sathya N. Thulasi Raman, Rose Anderson-Duvall, Levi Tamming, Caroline Gravel, Heather Coatsworth, Wangxue Chen, Michael J. W. Johnston, Simon Sauve, Michael Rosu-Myles, Lisheng Wang, Xuguang Li
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
The rising prevalence of Lyme disease (LD) in North America and Europe has emerged as a pressing public health concern. Despite the availability of veterinary LD vaccines, no vaccine is currently available for human use. Outer surface protein C (OspC
Externí odkaz:
https://doaj.org/article/837dc5a0535f48e28585ad366021997c
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Cystic fibrosis is a life-threatening disease that is caused by mutations in CFTR, a gene which encodes an ion channel that supports proper function of several epithelial tissues, most critically the lung. Without CFTR, airway barrier mechanisms are
Externí odkaz:
https://doaj.org/article/2eb8cca551f34e00a315f7dd26e0fd0c
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106681- (2024)
Lenadogene nolparvovec is a gene therapy which has been developed to treat Leber hereditary optic neuropathy (LHON) caused by a point mutation in the mitochondrial NADH dehydrogenase 4 (ND4) gene. Clinical trials have demonstrated a significant impro
Externí odkaz:
https://doaj.org/article/254ba0f4562143f28a868d12e6c4e99d
Autor:
Sang-Jin Park, Joung‐Wook Seo, Kang-Hyun Han, Byoung-Seok Lee, Chanyeong Lee, Bong Young Kim, Kyong-Cheol Ko, Yong-Bum Kim
Publikováno v:
Vaccine: X, Vol 20, Iss , Pp 100545- (2024)
The coronavirus disease 2019 (COVID-19) emerged as a major global health crisis, posing significant health, economic, and social challenges. Vaccine development has been a crucial response to the severe-acute-respiratory-syndrome-related coronavirus-
Externí odkaz:
https://doaj.org/article/30a2d4449301445f83a040adb42f0cea
Publikováno v:
BMC Biotechnology, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Since the 2000’s, plants have been used as bioreactors for the transient production of molecules of interest such as vaccines. To improve protein yield, “amplicon” vectors based on plant viruses are used. These viral constru
Externí odkaz:
https://doaj.org/article/f87257f57f184c409c9dfc38d83dc510
Autor:
Hongzhi Li, Jing Zhang, Yuqi Shen, Yifan Ye, Qingyou Jiang, Lan Chen, Bohao Sun, Zhuo Chen, Luxi Shen, Hezhi Fang, Jifeng Yang, Haihua Gu
Publikováno v:
Biological Procedures Online, Vol 26, Iss 1, Pp 1-15 (2024)
Abstract Background MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), original found in synthetic heroin, causes Parkinson’s disease (PD) in human through its metabolite MPP+ by inhibiting complex I of mitochondrial respiratory chain in dopamine
Externí odkaz:
https://doaj.org/article/15cc9dfaf1134b84a5d90d9c1059b105