Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Viral Reverse Transcription"'
The MOV10 helicase restricts hepatitis B virus replication by inhibiting viral reverse transcription
Publikováno v:
J Biol Chem
Interferons inhibit viruses by inducing antiviral protein expression. One of the interferon-induced antiviral proteins, human Moloney leukemia virus 10 (MOV10), a superfamily 1 RNA helicase, has been shown to inhibit retroviruses and several RNA viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0989e50a010b2a57e698d97594f8fa9
https://doi.org/10.1074/jbc.ra119.009435
https://doi.org/10.1074/jbc.ra119.009435
Publikováno v:
J Virol Methods
The hepatitis B virus (HBV) ribonuclease H (RNaseH) is a promising but unexploited drug target. Inhibiting the RNaseH blocks viral reverse transcription by truncating the minus-polarity DNA strand, causing accumulation of RNA:DNA heteroduplexes, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34093d769065c04e0a24c1c7b3ca5eb
https://pubmed.ncbi.nlm.nih.gov/33766659
https://pubmed.ncbi.nlm.nih.gov/33766659
Autor:
Nobutoki Takamune, Nozomi Iga, Naoki Kishimoto, Chie Kirihara, Shogo Misumi, Towa Abe, Kengo Yamamoto
Publikováno v:
Retrovirology
Retrovirology, Vol 17, Iss 1, Pp 1-12 (2020)
Retrovirology, Vol 17, Iss 1, Pp 1-12 (2020)
Background A protein exhibiting more than one biochemical function is termed a moonlighting protein. Glycolytic enzymes are typical moonlighting proteins, and these enzymes control the infection of various viruses. Previously, we reported that glycer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbdb7648072d7e051f98a77262de3a0
http://europepmc.org/articles/PMC7488571
http://europepmc.org/articles/PMC7488571
Autor:
Motoyuki Otsuka, Takahiro Seimiya, Takahiro Kishikawa, Tatsunori Suzuki, Motoko Ohno, Rei Ishibashi, Kazuma Sekiba, Kazuhiko Koike, Mari Yamagami, Eri Tanaka
Publikováno v:
Oncotarget
Hepatitis B virus (HBV) infection, which is a major health concern worldwide, can lead to liver cirrhosis and hepatocellular carcinoma. Although current nucleos(t)ide analogs efficiently inhibit viral reverse transcription and viral DNA load clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e36b78b1bb0893d195ffba0b6684e09
https://doi.org/10.18632/oncotarget.25104
https://doi.org/10.18632/oncotarget.25104
Autor:
Kei Sato, Naoko Misawa, Shinji Nakaoka, Tatsuya Kurusu, Shingo Iwami, Kwang Su Kim, Keisuke Ejima, Yoshio Koyanagi, Yoshiki Koizumi
Publikováno v:
Journal of theoretical biology. 498
APOBEC3 proteins inhibit human immunodeficiency virus (HIV)-1 infection by independently impairing viral reverse transcription and inducing G-to-A mutations in viral DNA. An HIV-1-encoded protein, viral infectivity factor (Vif), can counteract these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f768d209e24be655e12f3dfd55908519
https://pubmed.ncbi.nlm.nih.gov/32335137
https://pubmed.ncbi.nlm.nih.gov/32335137
Publikováno v:
Virol Sin
Hepatitis B virus (HBV) is characterized with high mutations, which is attributed to the lack of proof-reading of the viral reverse transcriptase and host immune pressure. In this study, 31 HBV chronic carriers from 14 families were enrolled to inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b897d46adabbd4be882416e9d3e5c2f
https://pubmed.ncbi.nlm.nih.gov/32124248
https://pubmed.ncbi.nlm.nih.gov/32124248
Autor:
P Martí, Mayte Coiras, Mercedes Bermejo, Sara Rodríguez-Mora, Susana Rocha, Javier García-Pérez, Lorena Vigón, Zeger Debyser, Elena Mateos, José Alcamí, Juan J. Vílchez, María Rosa López-Huertas, Frauke Christ, Flore De Wit
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 8, p e1007958 (2019)
Instituto de Salud Carlos III (ISCIII)
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 8, p e1007958 (2019)
The causative mutation responsible for limb girdle muscular dystrophy 1F (LGMD1F) is one heterozygous single nucleotide deletion in the stop codon of the nuclear import factor Transportin 3 gene (TNPO3). This mutation causes a carboxy-terminal extens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7a5654530de8f9fe5b0b370c0936da
https://lirias.kuleuven.be/handle/123456789/641066
https://lirias.kuleuven.be/handle/123456789/641066
Autor:
Edward M. Campbell, Anastasia Selyutina, Sabrina Imam, Jessica Mattick, Sevnur Kömürlü, Felipe Diaz-Griffero, Amani Eddins, Sarah Talley
Publikováno v:
Journal of Virology. 93
TRIM5α is an antiviral restriction factor that inhibits retroviral infection in a species-specific fashion. TRIM5α binds to and forms assemblies around the retroviral capsid. Following binding, poorly understood, ubiquitin-dependent events lead to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04652595c1d0dc2458e89662532d2396
https://doi.org/10.1128/jvi.00558-19
https://doi.org/10.1128/jvi.00558-19
Autor:
Nozomi Iga, Naoki Kishimoto, Nobutoki Takamune, Shozo Shoji, Shogo Misumi, Ayano Onitsuka-Kishimoto
Publikováno v:
Biochemistry and Biophysics Reports
Human immunodeficiency virus type-1 (HIV-1) requires the packaging of human tRNALys3 as a primer for effective viral reverse transcription. Previously, we reported that glyceraldehyde 3-phosphate dehydrogenase (GAPDH) suppresses the packaging efficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfb7b9158a30856a164fe7b1e6e321f
http://europepmc.org/articles/PMC5614461
http://europepmc.org/articles/PMC5614461
Autor:
Owen Pornillos, Wesley I. Sundquist
Publikováno v:
Cell Host & Microbe
Summary TRIM5 is a RING domain E3 ubiquitin ligase with potent antiretroviral function. TRIM5 assembles into a hexagonal lattice on retroviral capsids, causing envelopment of the infectious core. Concomitantly, TRIM5 initiates innate immune signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118da740e57bdf6d79c1c0a58fd795b4
https://pubmed.ncbi.nlm.nih.gov/30503508
https://pubmed.ncbi.nlm.nih.gov/30503508