Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome

Autor: Gary Loughran, Jeffrey W. Bode, Pramod R. Bhatt, Kate M. O’Connor, David Gatfield, Annika Kratzel, Volker Thiel, Nenad Ban, John F. Atkins, René Dreos, Marc Leibundgut, Romane Meurs, Alain Scaiola, Angus McMillan

Publikováno v: Science (New York, N.y.)
Science, vol. 372, no. 6548, pp. 1306-1313

Shifting frames to make more proteins Severe acute respiratory syndrome coronavirus 2 critically depends on the ribosomal frameshifting that occurs between two large open reading frames in its genomic RNA for expression of viral replicase. Programmed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b048a2925451cc1fd784af0742d4b762

The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth

Autor: Tian Shu Fan, Timo W.M. De Groof, Diane Van Hoorick, Henry F. Vischer, Maarten P. Bebelman, Laura Smits-de Vries, Afsar Rahbar, Marco Siderius, Jeffrey R. van Senten, Tonny Lagerweij, Raimond Heukers, Jody van Offenbeek, Raymond H. de Wit, Thomas Wurdinger, Rob Leurs, Cecilia Söderberg-Nauclér, Joao Vieira, Martine J. Smit, Sabrina M. de Munnik

Publikováno v: Oncogene
Oncogene, 37(30), 4110-4121. Nature Publishing Group
Heukers, R, Fan, T S, de Wit, R H, van Senten, J R, de Groof, T W M, Bebelman, M P, Lagerweij, T, Vieira, J, de Munnik, S M, Smits-de Vries, L, van Offenbeek, J, Rahbar, A, van Hoorick, D, Söderberg-Naucler, C, Würdinger, T, Leurs, R, Siderius, M, Vischer, H F & Smit, M J 2018, ' The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth ', Oncogene, vol. 37, no. 30, pp. 4110-4121 . https://doi.org/10.1038/s41388-018-0255-7
Oncogene, 2018(30), 1-12. Nature Publishing Group
Heukers, R, Fan, T S, de Wit, R H, van Senten, J R, de Groof, T W M, Bebelman, M P, Lagerweij, T, Vieira, J, de Munnik, S M, Smits-de Vries, L, van Offenbeek, J, Rahbar, A, van Hoorick, D, Söderberg-Naucler, C, Würdinger, T, Leurs, R, Siderius, M, Vischer, H F & Smit, M J 2018, ' The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth ', Oncogene, vol. 2018, no. 30, pp. 1-12 . https://doi.org/10.1038/s41388-018-0255-7

Glioblastoma (GBM) is the most aggressive and an incurable type of brain cancer. Human cytomegalovirus (HCMV) DNA and encoded proteins, including the chemokine receptor US28, have been detected in GBM tumors. US28 displays constitutive activity and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d2b143f496bc5734d97f476890189d
http://europepmc.org/articles/PMC6062493

N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death

Autor: Sebastien Causse, Renaud Seigneuric, Eva Szegezdi, Sarah Shirley, Guillaume Herlem, Aymeric Morlé, Tijani Gharbi, Florent Dufour, Andrei Constantinescu, Gilles Guichard, Al Batoul Zakaria, Olivier Micheau, Pascal Schneider, Gaelle Picarda, Thibault Rattier, Fabien Picaud, Guillaume Marcion, Dirk M. Zajonc, Carmen Garrido, Chris A. Benedict

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2017, [Epub ahead of print]. ⟨10.1038/cdd.2016.150⟩
Cell death and differentiation, vol. 24, no. 3, pp. 500-510

International audience; APO2L/TRAIL (TNF-related apoptosis-inducing ligand) induces death of tumor cells through two agonist receptors, TRAIL-R1 and TRAIL-R2. We demonstrate here that N-linked glycosylation (N-glyc) plays also an important regulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41691b65bb3cbadb464044124dae0bca
https://doi.org/10.1038/cdd.2016.150

Differential expression of a prophage-encoded glycocin and its immunity protein suggests a mutualistic strategy of a phage and its host

Autor: Emma L. Denham, Ewoud Reilman, Sjouke Piersma, Marleen Rinket, Marcus C. de Goffau, Jan Maarten van Dijl

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, 9(1). Nature Publishing Group
Scientific Reports
Scientific Reports, 9(1):2845. Nature Publishing Group

Sublancin 168 is a highly potent and stable antimicrobial peptide secreted by the Gram-positive bacterium Bacillus subtilis. Production of sublancin gives B. subtilis a major competitive growth advantage over a range of other bacteria thriving in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b107b2dc6263a1772f5ccc6d9382d27b
https://doi.org/10.1038/s41598-019-39169-3

Partner-Mediated Polymorphism of an Intrinsically Disordered Protein

Autor: Christophe Bignon, Sonia Longhi, Francesca Troilo, Stefano Gianni

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2018, 16 (3), pp.2493-2507. ⟨10.1016/j.jmb.2017.11.012⟩
Journal of Molecular Biology, Elsevier, 2017, 〈10.1016/j.jmb.2017.11.012〉
Journal of Molecular Biology 430 (2018): 2493–2507. doi:10.1016/j.jmb.2017.11.012
info:cnr-pdr/source/autori:Bignon C.; Troilo F.; Gianni S.; Longhi S./titolo:Partner-Mediated Polymorphism of an Intrinsically Disordered Protein/doi:10.1016%2Fj.jmb.2017.11.012/rivista:Journal of Molecular Biology/anno:2018/pagina_da:2493/pagina_a:2507/intervallo_pagine:2493–2507/volume:430
Journal of Molecular Biology, Elsevier, 2017, ⟨10.1016/j.jmb.2017.11.012⟩
Journal of Molecular Biology, 2017, ⟨10.1016/j.jmb.2017.11.012⟩

International audience; Intrinsically disordered proteins (IDPs) recognize their partners through molecular recognition elements (MoREs). The MoRE of the C-terminal intrinsically disordered domain of the measles virus nucleoprotein (NTAIL) is partly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1c6a3c7e170b3725e577eba7c71f08
https://hal.archives-ouvertes.fr/hal-01802951