Výsledky vyhledávání - "Viral Proteins/chemistry"

Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome

Autor: Gary Loughran, Jeffrey W. Bode, Pramod R. Bhatt, Kate M. O’Connor, David Gatfield, Annika Kratzel, Volker Thiel, Nenad Ban, John F. Atkins, René Dreos, Marc Leibundgut, Romane Meurs, Alain Scaiola, Angus McMillan

Publikováno v: Science (New York, N.y.)
Science, vol. 372, no. 6548, pp. 1306-1313

Shifting frames to make more proteins Severe acute respiratory syndrome coronavirus 2 critically depends on the ribosomal frameshifting that occurs between two large open reading frames in its genomic RNA for expression of viral replicase. Programmed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b048a2925451cc1fd784af0742d4b762

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HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation

Autor: Mary Carrington, Tobias L. Lenz, Federica Pierini, Jacques Fellay, Paul J. McLaren, Jatin Arora

Publikováno v: Molecular biology and evolution, vol. 37, no. 3, pp. 639-650
Molecular Biology and Evolution

Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic diversity. A hallmark for balancing selection in humans is the heterozygote advantage at genes of the human leukocyte antigen (HLA), resulting in improved HIV-1 c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996687938bd13cc63fdb99d363b53a5f
https://serval.unil.ch/resource/serval:BIB_4A4E20C0A676.P001/REF.pdf

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Partner-Mediated Polymorphism of an Intrinsically Disordered Protein

Autor: Christophe Bignon, Sonia Longhi, Francesca Troilo, Stefano Gianni

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2018, 16 (3), pp.2493-2507. ⟨10.1016/j.jmb.2017.11.012⟩
Journal of Molecular Biology, Elsevier, 2017, 〈10.1016/j.jmb.2017.11.012〉
Journal of Molecular Biology 430 (2018): 2493–2507. doi:10.1016/j.jmb.2017.11.012
info:cnr-pdr/source/autori:Bignon C.; Troilo F.; Gianni S.; Longhi S./titolo:Partner-Mediated Polymorphism of an Intrinsically Disordered Protein/doi:10.1016%2Fj.jmb.2017.11.012/rivista:Journal of Molecular Biology/anno:2018/pagina_da:2493/pagina_a:2507/intervallo_pagine:2493–2507/volume:430
Journal of Molecular Biology, Elsevier, 2017, ⟨10.1016/j.jmb.2017.11.012⟩
Journal of Molecular Biology, 2017, ⟨10.1016/j.jmb.2017.11.012⟩

International audience; Intrinsically disordered proteins (IDPs) recognize their partners through molecular recognition elements (MoREs). The MoRE of the C-terminal intrinsically disordered domain of the measles virus nucleoprotein (NTAIL) is partly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1c6a3c7e170b3725e577eba7c71f08
https://hal.archives-ouvertes.fr/hal-01802951

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Deciphering the unconventional peptide binding to the PDZ domain of MAST2

Autor: Florence Cordier, Nicolas Wolff, Henri Buc, Bertrand Raynal, Elouan Terrien, Muriel Delepierre, Alain Chaffotte, Florent Delhommel

Publikováno v: Biochemical Journal
Biochemical Journal, Portland Press, 2015, 469 (1), pp.159-168. ⟨10.1042/BJ20141198⟩
Biochemical Journal, 2015, 469 (1), pp.159-168. ⟨10.1042/BJ20141198⟩

Phosphatase and tensin homologue (PTEN) and microtubule-associated serine threonine kinase 2 (MAST2) are key negative regulators of survival pathways in neuronal cells. The two proteins interact via the PDZ (PSD-95, Dlg1, Zo-1) domain of MAST2 (MAST2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4686c21e9c3b7509080eb7a4c0a244
https://doi.org/10.1042/bj20141198

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Multiple Regions of Kaposi’s Sarcoma-Associated Herpesvirus ORF59 RNA are Required for Its Expression Mediated by Viral ORF57 and Cellular RBM15

Autor: Vladimir Majerciak, Maria J. Massimelli, David J. Liewehr, Zhi-Ming Zheng, Seth M. Steinberg, Jeong-Gu Kang

Publikováno v: Viruses, Vol 7, Iss 2, Pp 496-510 (2015)
Viruses
Massimelli, MJ; Majerciak, V; Kang, JG; Liewehr, DJ; Steinberg, SM; & Zheng, ZM. (2015). Multiple regions of Kaposi’s Sarcoma-associated herpesvirus ORF59 RNA are required for its expression mediated by viral ORF57 and cellular RBM15. Viruses, 7(2), 496-510. doi: 10.3390/v7020496. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/92x0j507
Viruses, vol 7, iss 2
Viruses, 7(2), 496-510. Multidisciplinary Digital Publishing Institute (MDPI)

© 2015 by the authors; licensee MDPI, Basel, Switzerland. KSHV ORF57 (MTA) promotes RNA stability of ORF59, a viral DNA polymerase processivity factor. Here, we show that the integrity of both ORF59 RNA ends is necessary for ORF57-mediated ORF59 exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5751d7aa4bce0b95e77b67ded904cb70
http://www.mdpi.com/1999-4915/7/2/496

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DNA-Interacting Characteristics of the Archaeal Rudiviral Protein SIRV2_Gp1

Autor: Clare Rollie, Eveline Peeters, M. Boon, Tessa E. F. Quax, Malcolm F. White, Rob Lavigne, Marleen Voet, David Prangishvili, Ronnie Willaert

Publikováno v: Viruses, Vol 9, Iss 7, p 190 (2017)
Viruses
Viruses, 9(7):190. MDPI AG
Viruses; Volume 9; Issue 7; Pages: 190

Whereas the infection cycles of many bacterial and eukaryotic viruses have been characterized in detail, those of archaeal viruses remain largely unexplored. Recently, studies on a few model archaeal viruses such as SIRV2 (Sulfolobus islandicus rod-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770953151d28ef2e4964d26684b2e25b
https://www.mdpi.com/1999-4915/9/7/190

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Molecular modeling studies demonstrate key mutations that could affect the ligand recognition by influenza AH1N1 neuraminidase

Autor: Saúl Rojas-Hernández, Gema Lizbeth Ramírez-Salinas, Mirko Zimic, Verónica Briz, Miguel Quiliano, José Correa-Basurto, Jazmín García-Machorro

Publikováno v: Journal of Molecular Modeling. 21

The goal of this study was to identify neuraminidase (NA) residue mutants from human influenza AH1N1 using sequences from 1918 to 2012. Multiple alignment studies of complete NA sequences (5732) were performed. Subsequently, the crystallographic stru

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https://doi.org/10.1007/s00894-015-2835-6

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Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase

Autor: Emily Flashman, Colin Levy, Christopher J. Schofield, Nigel S. Scrutton, Christoph Loenarz, James E. Longbotham, Hanna Tarhonskaya, Sam Hay, Linus O. Johannissen, Shuo Jiang

Publikováno v: Longbotham, J E, Levy, C, Johannissen, L O, Tarhonskaya, H, Jiang, S, Loenarz, C, Flashman, E, Hay, S, Schofield, C J & Scrutton, N S 2015, ' Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase ', Biochemistry, vol. 54, no. 39, pp. 6093-6105 . https://doi.org/10.1021/acs.biochem.5b00789, https://doi.org/10.1021/acs.biochem.5b00789
Biochemistry

The Fe(II)- and 2-oxoglutarate (2-OG)-dependent dioxygenases comprise a large and diverse enzyme superfamily the members of which have multiple physiological roles. Despite this diversity, these enzymes share a common chemical mechanism and a core st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee79b4444f6ab443cfae678d65fbfeb8
https://doi.org/10.1021/acs.biochem.5b00789

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Inhibition of viral assembly in murine cells by HIV-1 matrix

Autor: Wolfgang Hübner, Benjamin K. Chen

Publikováno v: Virology. 352:27-38

In human cells, the N-terminal matrix (MA) domain of the human immunodeficiency virus type 1 (HIV-1) Gag targets assembly to specific membrane compartments. In murine fibroblasts, membrane targeting of Gag and assembly of HIV-1 are inefficient. These

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f58dd4c433e99acb89ec7a389e0882c
https://doi.org/10.1016/j.virol.2006.04.024

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