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Role of Motif B Loop in Allosteric Regulation of RNA-Dependent RNA Polymerization Activity

Autor: Cristina Ferrer-Orta, Jordi Querol-Audí, Baldo Oliva, Damià Garriga, Núria Verdaguer

Publikováno v: Journal of Molecular Biology; Vol 425
Digital.CSIC. Repositorio Institucional del CSIC
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Increasing amounts of data show that conformational dynamics are essential for protein function. Unveiling the mechanisms by which this flexibility affects the activity of a given enzyme and how it is controlled by other effectors opens the door to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d395bb47cba4e551f003a4fb9f6a08f1
https://doi.org/10.1016/j.jmb.2013.03.034

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

Autor: Xavier de Lamballerie, Bruno Canard, Ernest A. Gould, Erika J. Mancini, Rene Assenberg, Silvia Speroni, Hélène Malet, Gregory Moureau, Anna M. Jansson, Martino Bolognesi, Barbara Selisko, Johan Neyts, Rolf Hilgenfeld, Michela Bollati, Jonathan M. Grimes, Raymond J. Owens, David I. Stuart, Bruno Coutard, Mario Milani, Holger Steuber, Andrea Mattevi, Eloise Mastrangelo, Jingshan Ren, Cécile Baronti, Etienne Decroly, Torsten Unge, Karin Alvarez, Shelley Cook, Gilda Grard

Publikováno v: Antiviral Research
Antiviral research
87 (2010): 125–148. doi:10.1016/j.antiviral.2009.11.009
info:cnr-pdr/source/autori:Bollati M.; K. Alvarez; R. Assenberg; C. Baronti; B. Canard; S. Cook; B. Coutard; E. Decroly; X. de Lamballerie; E.A. Gould; G. Grard; J.M. Grimes; R. Hilgenfeld; A.M. Jansson; H. Malet; E.J. Mancini; E. Mastrangelo; A. Mattevi; M. Milani; G. Moureau, J./titolo:Structure and functionality in flavivirus NS-proteins: Perspectives for drug design/doi:10.1016%2Fj.antiviral.2009.11.009/rivista:Antiviral research (Print)/anno:2010/pagina_da:125/pagina_a:148/intervallo_pagine:125–148/volume:87

Flaviviridae are small enveloped viruses hosting a positive-sense single-stranded RNA genome. Besides yellow fever virus, a landmark case in the history of virology, members of the Flavivirus genus, such as West Nile virus and dengue virus, are incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3100478119ff8862457b51960b0d0797
https://doi.org/10.1016/j.antiviral.2009.11.009

Antiviral strategies to control calicivirus infections

Autor: Jacques Rohayem, Torsten Unge, Mirko Bergmann, Andrea Mattevi, Johan Neyts, Julia Gebhardt, Rolf Hilgenfeld, Paul A. Tucker, Ernest A. Gould

Publikováno v: Antiviral Research

Caliciviridae are human or non-human pathogenic viruses with a high diversity. Some members of the Caliciviridae, i.e. human pathogenic norovirus or rabbit hemorrhagic disease virus (RHDV), are worldwide emerging pathogens. The norovirus is the major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4945667e42359f528bcfd8e70b10bf80
https://doi.org/10.1016/j.antiviral.2010.05.002

Recombination in Enteroviruses Is a Biphasic Replicative Process Involving the Generation of Greater-than Genome Length ‘Imprecise’ Intermediates

Autor: Lowry, Kym, Woodman, Andrew, Cook, Jonathan P., Evans, David J.

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 10, Iss 6, p e1004191 (2014)

Recombination in enteroviruses provides an evolutionary mechanism for acquiring extensive regions of novel sequence, is suggested to have a role in genotype diversity and is known to have been key to the emergence of novel neuropathogenic variants of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8134375345af224cee7339ec51d9d80f
http://europepmc.org/articles/PMC4055744