Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Vira Patel"'
Autor:
Claude Dufresne, Ernest Asante-Appiah, Yves Leblanc, Vira Patel, Richard Friesen, Chidambaram Ramachandran, Brian P. Kennedy, Giovanna Scapin, Joseph W. Becker, Patrick Roy, Qingping Wang, Sangita B. Patel
Publikováno v:
Biochemistry. 41:9043-9051
Inhibitors of PTP-1B could be therapeutically beneficial in the treatment of type 2 diabetes. Owing to the large number of phosphatases in the cell, inhibitors against PTP-1B must not only be potent but selective as well. N-Benzoyl-L-glutamyl-[4-phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ecf8cc038338a776d5e8219c3a4f7d
https://doi.org/10.1021/bi0259554
https://doi.org/10.1021/bi0259554
Publikováno v:
Protein science : a publication of the Protein Society. 10(8)
Protein-tyrosine phosphatases catalyze the hydrolysis of phosphate monoesters via a two-step mechanism involving a covalent phospho-enzyme intermediate. Biochemical and site-directed mutagenesis experiments show that the invariant Cys residue present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94b9d913313331862e76f3d6333a2c7
https://pubmed.ncbi.nlm.nih.gov/11468356
https://pubmed.ncbi.nlm.nih.gov/11468356