Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Vira Kravets"'
Autor:
Nirmala V. Balasenthilkumaran, Jennifer C. Whitesell, Laura Pyle, Rachel S. Friedman, Vira Kravets
Publikováno v:
Frontiers in Network Physiology, Vol 4 (2024)
One of the challenges in studying islet inflammation–insulitis–is that it is a transient phenomenon. Traditional reporting of the insulitis progression is based on cumulative, donor-averaged values of leucocyte density in the vicinity of pancreat
Externí odkaz:
https://doaj.org/article/fc353adb09c34af7af45bfa39518745e
Autor:
Marko Šterk, Yaowen Zhang, Viljem Pohorec, Eva Paradiž Leitgeb, Jurij Dolenšek, Richard K P Benninger, Andraž Stožer, Vira Kravets, Marko Gosak
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 5, p e1012130 (2024)
Within the islets of Langerhans, beta cells orchestrate synchronized insulin secretion, a pivotal aspect of metabolic homeostasis. Despite the inherent heterogeneity and multimodal activity of individual cells, intercellular coupling acts as a homoge
Externí odkaz:
https://doaj.org/article/8347d06d07734c829efed481627ebe78
Autor:
Jennifer K Briggs, Anne Gresch, Isabella Marinelli, JaeAnn M Dwulet, David J Albers, Vira Kravets, Richard KP Benninger
Publikováno v:
eLife, Vol 12 (2023)
Diabetes is caused by the inability of electrically coupled, functionally heterogeneous β-cells within the pancreatic islet to provide adequate insulin secretion. Functional networks have been used to represent synchronized oscillatory [Ca2+] dynami
Externí odkaz:
https://doaj.org/article/4b9836aacff5411489a467e2968afa6b
Autor:
Vira Kravets, JaeAnn M Dwulet, Wolfgang E Schleicher, David J Hodson, Anna M Davis, Laura Pyle, Robert A Piscopio, Maura Sticco-Ivins, Richard K P Benninger
Publikováno v:
PLoS Biology, Vol 20, Iss 9, p e3001761 (2022)
Insulin-secreting β-cells are functionally heterogeneous. Whether there exist cells driving the first-phase calcium response in individual islets, has not been examined. We examine "first responder" cells, defined by the earliest [Ca2+] response dur
Externí odkaz:
https://doaj.org/article/9640275cc251401eb2cb503ecea4e967
Autor:
Arjun K. Fontaine, David G. Ramirez, Samuel F. Littich, Robert A. Piscopio, Vira Kravets, Wolfgang E. Schleicher, Naoko Mizoguchi, John H. Caldwell, Richard F. ff. Weir, Richard K. P. Benninger
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Previous studies have demonstrated stimulation of endocrine pancreas function by vagal nerve electrical stimulation. While this increases insulin secretion, expected concomitant reductions in circulating glucose do not occur. A complicating
Externí odkaz:
https://doaj.org/article/a57569d33df4487d82b410837e3941d0
Autor:
Melissa T Adams, JaeAnn M Dwulet, Jennifer K Briggs, Christopher A Reissaus, Erli Jin, Joseph M Szulczewski, Melissa R Lyman, Sophia M Sdao, Vira Kravets, Sutichot D Nimkulrat, Suzanne M Ponik, Matthew J Merrins, Raghavendra G Mirmira, Amelia K Linnemann, Richard KP Benninger, Barak Blum
Publikováno v:
eLife, Vol 10 (2021)
The spatial architecture of the islets of Langerhans is hypothesized to facilitate synchronized insulin secretion among β cells, yet testing this in vivo in the intact pancreas is challenging. Robo βKO mice, in which the genes Robo1 and Robo2 are d
Externí odkaz:
https://doaj.org/article/6ffc13e7f9f7467bb80f8e6003960f0d
Autor:
Kim-Vy Nguyen-Ngoc, Yesl Jun, Somesh Sai, R. Hugh F. Bender, Vira Kravets, Han Zhu, Christopher J. Hatch, Michael Schlichting, Roberto Gaetani, Medhavi Mallick, Stephanie J. Hachey, Karen L. Christman, Steven C. George, Christopher C.W. Hughes, Maike Sander
Blood vessels play a critical role in pancreatic islet health and function, yet current culture methods to generate islet organoids from human pluripotent stem cells (SC-islets) lack a vascular component. Here, we engineered 3D vascularized SC-islet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11e93582a9d7eda0944651a62048846a
https://doi.org/10.1101/2022.10.28.513298
https://doi.org/10.1101/2022.10.28.513298
Autor:
Richard K.P. Benninger, Nikki L. Farnsworth, Maria Esméria Corezola do Amaral, Vira Kravets, JaeAnn M. Dwulet, Wolfgang E. Schleicher, Jose Guadalupe Miranda, Robert A. Piscopio
Publikováno v:
Am J Physiol Endocrinol Metab
Caloric restriction can decrease the incidence of metabolic diseases, such as obesity and Type 2 diabetes mellitus. The mechanisms underlying the benefits of caloric restriction involved in insulin secretion and glucose homeostasis are not fully unde
Diabetes is caused by dysfunction of electrically coupled heterogeneous β-cells within the pancreatic islet. Functional networks have been used to represent cellular synchronization and study β-cells subpopulations, which play an important role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dda14d91b3330e27e169b75d1a52ab1
https://doi.org/10.1101/2022.02.06.479331
https://doi.org/10.1101/2022.02.06.479331
Autor:
Vira Kravets, Richard K.P. Benninger
Publikováno v:
Nat Rev Endocrinol
Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of transcriptional profile, protein expression and the regulation of hormone release. Even though this heterogeneity has long been appreciated, only within the past
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca0894692a341bb6c7fcbb919eb2476
https://europepmc.org/articles/PMC8915749/
https://europepmc.org/articles/PMC8915749/