Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Vipul Periwal"'
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 11, p e1011617 (2023)
The islets of Langerhans are critical endocrine micro-organs that secrete hormones regulating energy metabolism in animals. Insulin and glucagon, secreted by beta and alpha cells, respectively, are responsible for metabolic switching between fat and
Externí odkaz:
https://doaj.org/article/0bc03a2e37d74b8bba0b9fcb2130c8c3
Publikováno v:
The Astrophysical Journal, Vol 975, Iss 1, p 95 (2024)
The structure of the low redshift Universe is dominated by a multiscale void distribution delineated by filaments and walls of galaxies. The characteristics of voids, such as morphology, average density profile, and correlation function, can be used
Externí odkaz:
https://doaj.org/article/93316354ac394fb3a34174cc45cfe47e
Autor:
Manu Aggarwal, Vipul Periwal
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 5, p e1010341 (2023)
Persistent homology (PH) is a popular tool for topological data analysis that has found applications across diverse areas of research. It provides a rigorous method to compute robust topological features in discrete experimental observations that oft
Externí odkaz:
https://doaj.org/article/af7ced97153f48e8958ca9d344f9eb9c
Autor:
Anthony V Furano, Charlie E Jones, Vipul Periwal, Kathryn E Callahan, Jean-Claude Walser, Pamela R Cook
Publikováno v:
PLoS Genetics, Vol 16, Iss 8, p e1008991 (2020)
Accounting for continual evolution of deleterious L1 retrotransposon families, which can contain hundreds to thousands of members remains a major issue in mammalian biology. L1 activity generated upwards of 40% of some mammalian genomes, including hu
Externí odkaz:
https://doaj.org/article/36ead044c58f45f5959a9a1e4683e32b
Autor:
Jung Min Han, Vipul Periwal
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 8, p e1006661 (2019)
Multiple cellular organelles tightly orchestrate intracellular calcium (Ca2+) dynamics to regulate cellular activities and maintain homeostasis. The interplay between the endoplasmic reticulum (ER), a major store of intracellular Ca2+, and mitochondr
Externí odkaz:
https://doaj.org/article/9d479a0dc57648f485e8474e3cccea63
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 8, p e1004423 (2015)
Pancreatic islets of Langerhans consist of endocrine cells, primarily α, β and δ cells, which secrete glucagon, insulin, and somatostatin, respectively, to regulate plasma glucose. β cells form irregular locally connected clusters within islets t
Externí odkaz:
https://doaj.org/article/42a5f65e99ee4351aa7bc438b92de83f
Autor:
Zeina Shreif, Vipul Periwal
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 2, p e1003474 (2014)
As scientific advances in perturbing biological systems and technological advances in data acquisition allow the large-scale quantitative analysis of biological function, the robustness of organisms to both transient environmental stresses and inter-
Externí odkaz:
https://doaj.org/article/1fe756b2e5944cc8b22501643af8aba9
Autor:
Danh-Tai Hoang, Hitomi Matsunari, Masaki Nagaya, Hiroshi Nagashima, J Michael Millis, Piotr Witkowski, Vipul Periwal, Manami Hara, Junghyo Jo
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110384 (2014)
Morphogenesis, spontaneous formation of organism structure, is essential for life. In the pancreas, endocrine α, β, and δ cells are clustered to form islets of Langerhans, the critical micro-organ for glucose homeostasis. The spatial organization
Externí odkaz:
https://doaj.org/article/c7251a5acf274f8494548468db7151ee
Autor:
Xiaojun Wang, Ryosuke Misawa, Mark C Zielinski, Peter Cowen, Junghyo Jo, Vipul Periwal, Camillo Ricordi, Aisha Khan, Joel Szust, Junhui Shen, J Michael Millis, Piotr Witkowski, Manami Hara
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67454 (2013)
While regional heterogeneity in islet distribution has been well studied in rodents, less is known about human pancreatic histology. To fill gaps in our understanding, regional differences in the adult human pancreas were quantitatively analyzed incl
Externí odkaz:
https://doaj.org/article/294362062bfd4651941a1f6709057d87
Autor:
German Kilimnik, Billy Zhao, Junghyo Jo, Vipul Periwal, Piotr Witkowski, Ryosuke Misawa, Manami Hara
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27445 (2011)
Human islets exhibit distinct islet architecture with intermingled alpha- and beta-cells particularly in large islets. In this study, we quantitatively examined pathological changes of the pancreas in patients with type 2 diabetes (T2D). Specifically
Externí odkaz:
https://doaj.org/article/3b84b7ae65924283bdb0729c1164fe92