Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Vipul M. Parmar"'
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103150- (2024)
Summary: During aging and in retinal degenerative diseases, vulnerable retinal pigment epithelial (RPE) cells are subject to mitochondrial dysfunction, creating a need for accessibility to tools which can facilitate assessment of the ocular posterior
Externí odkaz:
https://doaj.org/article/f61feaede64c4babacb3ddd32fbbd7a8
Publikováno v:
Cells, Vol 11, Iss 24, p 3948 (2022)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/b6cc203a0c5f4d83bf431a395cba200b
Publikováno v:
Cells, Vol 11, Iss 15, p 2386 (2022)
The choroid is a vulnerable tissue site in the eye, impacted in several blinding diseases including age related macular degeneration (AMD), which is the leading cause of central vision loss in the aging population. Choroidal thinning and choriocapill
Externí odkaz:
https://doaj.org/article/b373c03bb6014f7db8ebba9ff279bfe8
Autor:
Srinivasagan Ramkumar, Vipul M. Parmar, Jean Moon, Chieh Lee, Patricia R. Taylor, Johannes von Lintig
Publikováno v:
Antioxidants, Vol 11, Iss 6, p 1142 (2022)
Emerging evidence indicates that diabetes disturbs photoreceptor function and vitamin A homeostasis. However, the biochemical basis of this phenotype is not well established. Here, we compared the effects of streptozotocin-induced diabetes in wild-ty
Externí odkaz:
https://doaj.org/article/a19ce345750246e9a4a6a3fa36d23083
Publikováno v:
Stem Cell Research, Vol 27, Iss , Pp 95-104 (2018)
Accumulation of lipofuscin in the retinal pigmented epithelium (RPE) is observed in retinal degenerative diseases including Stargardt disease and age-related macular degeneration. Bis-retinoid N-retinyl-N-retinylidene ethanolamine (A2E) is a major co
Externí odkaz:
https://doaj.org/article/fb520ff66a75468e9d74fa07c175268f
Autor:
Srinivasagan Ramkumar, Ivy S. Samuels, Nathan A. Berger, Beata Jastrzebska, Vipul M. Parmar, Johannes von Lintig
Publikováno v:
Hum Mol Genet
The retinal pigment epithelium of the vertebrate eyes acquires vitamin A from circulating retinol binding protein for chromophore biosynthesis. The chromophore covalently links with an opsin protein in the adjacent photoreceptors of the retina to for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061f837c0a7f99f1a558b466af703aee
https://europepmc.org/articles/PMC8863423/
https://europepmc.org/articles/PMC8863423/
Autor:
Vipul M. Parmar, Paul S.-H. Park, Subhadip Senapati, Ivy S. Samuels, Akiko Maeda, Megan Gragg
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1860(6)
Docosahexaenoic acid (DHA) is enriched in photoreceptor cell membranes. DHA deficiency impairs vision due to photoreceptor cell dysfunction, which is caused, at least in part, by reduced activity of rhodopsin, the light receptor that initiates photot
Autor:
Vipul M. Parmar, Masayo Takahashi, John W. Crabb, Tanu Parmar, Akiko Maeda, Lindsay Perusek, Anouk Georges
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(9)
It has become increasingly important to understand how retinal inflammation is regulated because inflammation plays a role in retinal degenerative diseases. Lipocalin 2 (LCN2), an acute stress response protein with multiple innate immune functions, i
Autor:
Bhubanananda Sahu, Subhadip Senapati, Akiko Maeda, Paul S.-H. Park, Vipul M. Parmar, Tatini Rakshit
The light-sensing rod photoreceptor cell exhibits several adaptations in response to the lighting environment. While adaptations to short-term changes in lighting conditions have been examined in depth, adaptations to long-term changes in lighting co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1321ceaefe05fba23b4ca8a4dc3265ec
https://europepmc.org/articles/PMC5581674/
https://europepmc.org/articles/PMC5581674/
Publikováno v:
Neuroscience research. 123
Retinal tissues generated from human pluripotent stem cells can be an excellent tool for investigating pathogenesis of retinal diseases and developing new pharmacologic therapies. Moreover, patient derived retinal tissues could allow for retinal tran