Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1

Autor: Nicole Hafkemeijer, Ari Ora, Judith Klumperman, Rudi Glockshuber, Chantal Christis, Viorica Lástun, Jeremy Luban, Florentina Pena, Thomas Pertel, Sander Engels, Albert J. R. Heck, Ulla Grauschopf, Edwin P. Romijn, Viola Oorschot, Ineke Braakman, Eelco van Anken

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences, Vol. 106, No 40 (2009) pp. 17019-17024

Plasma cells daily secrete their own mass in antibodies, which fold and assemble in the endoplasmic reticulum (ER). To reach these levels, cells require pERp1, a novel lymphocyte-specific small ER-resident protein, which attains expression levels as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa170b41778ae21cbe1bbda82ff7db9