Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Violette, Paragas"'
Autor:
Ulrik B. Nielsen, Birgit Schoeberl, Arthur J. Kudla, Michael J. Feldhaus, Matt Wallace, Neeraj Kohli, Jinming Gu, Stephanie Nguyen, Ryan Overland, Lia Luus, Bo Zhang, Shinji Oyama, Violette Paragas, Sharlene Adams, Brian D. Harms, Alexandra Huhalov, Charlotte F. McDonagh
PDF file - 189K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740c3b57b3148fec19b2a1932a1c942b
https://doi.org/10.1158/1535-7163.22498605
https://doi.org/10.1158/1535-7163.22498605
Autor:
Violette Paragas, Jacob V. Layer, Marc Güell, William F. Westlin, Luhan Yang, Juan Xiong, Weilin Wang, Shengyi Mao, Yinan Kan, Ranjith P. Anand, Deling Jiao, Zhongquan Sun, Mengyuan Xu, George M. Church, Lydia Lamriben, Xiaobin Song, Yu Luo, Lei Le, Hong-Ye Zhao, Hong-Jiang Wei, Michele Youd, Mailin Li, Yangbin Gao, Qi Zhang, Hongwei Dou, Dharmendra Goswami, Haydy George, Meng Yang, Yanan Yue, Yixuan Zhou, Zhuo Li, Shi Yun Wang, Lingling Song, James F. Markmann, Yuan Ding, Wenning Qin, Xueqiong Wang, Jiajia Wu, Tien Dat Nguyen, Xin Fang, Jianxiong Guo, Weihong Xu
Publikováno v:
Nature Biomedical Engineering. 5:134-143
The clinical applicability of porcine xenotransplantation-a long-investigated alternative to the scarce availability of human organs for patients with organ failure-is limited by molecular incompatibilities between the immune systems of pigs and huma
Autor:
Grace Lassiter, Takayuki Hirose, David Ma, Ashley D’Attilio, Ivy Rosales, Rudy Matheson, Daniel Cloonan, Robert B. Colvin, Wenning Qin, Yinan Kan, Jacob Layer, Ranjith Anand, Violette Paragas, Luis Queroz, Xiaoqing Tan, Ian Kohnle, Katherine Stiede, Katherine Hall, Michele Youd, Michael Curtis, James F. Markmann, Tatsuo Kawai
Publikováno v:
Transplantation. 106:S418-S418
Autor:
Luhan Yang, Kathryn Stiede, James F. Markmann, Rudy Matheson, Luis M Queiroz, Jacob V. Layer, Michael Curtis, Yinan Kan, Ivy A. Rosales, David W.L. Ma, Katherine C Hall, Taylor M. Coe, Michele Youd, Charles G. Rickert, Robert B. Colvin, Hajime Sasaki, Wenning Qin, Takayuki Hirose, William F. Westlin, Violette Paragas, Tatsuo Kawai, Grace Lassiter
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 22(1)
Porcine cells devoid of three major carbohydrate xenoantigens, αGal, Neu5GC, and SDa (TKO) exhibit markedly reduced binding of human natural antibodies. Therefore, it is anticipated that TKO pigs will be better donors for human xenotransplantation.
Autor:
Ranjith P. Anand, Yu Luo, Shi Yun Wang, Hong-Jiang Wei, Juan Xiong, Deling Jiao, Violette Paragas, Yinan Kan, Yangbin Gao, Wenning Qin, Tien Dat Nguyen, George M. Church, Hongwei Dou, Jianxiong Guo, Yixuan Zhou, Shengyi Mao, Weihong Xu, Marc Güell, Jacob V. Layer, Hong-Ye Zhao, Mailin Li, Xin Fang, Xiaobin Song, Qi Zhang, Lei Le, William F. Westlin, Luhan Yang, Zhuo Li, Lingling Song, Xueqiong Wang, Jiajia Wu, Yuan Ding, James F. Markmann, Lydia Lamriben, Michele Youd, Weilin Wang, Zhongquan Sun, Mengyuan Xu, Meng Yang, Dharmendra Goswami, Yanan Yue, Haydy George
Xenotransplantation, specifically the use of porcine organs for human transplantation, has long been sought after as an alternative for patients suffering from organ failure. However, clinical application of this approach has been impeded by two main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a3dbf2be5e71b1ce5cbdd292ed0d75
https://doi.org/10.1101/2019.12.17.876862
https://doi.org/10.1101/2019.12.17.876862
Autor:
Jens Timmer, Violette Paragas, Mark Sevecka, John E. Allen, Emily Pace, Joerg Stelling, Gavin MacBeath, Helge Hass, Kristina Masson, Birgit Schoeberl, Sibylle Wohlgemuth, Andreas Raue
Publikováno v:
npj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-15 (2017)
NPJ Systems Biology and Applications
npj Systems Biology and Applications, 3
NPJ Systems Biology and Applications
npj Systems Biology and Applications, 3
Targeted therapies have shown significant patient benefit in about 5–10% of solid tumors that are addicted to a single oncogene. Here, we explore the idea of ligand addiction as a driver of tumor growth. High ligand levels in tumors have been shown
Antibody-mediated targeting of TNFR2 activates CD8 + T cells in mice and promotes antitumor immunity
Autor:
Wenlian Qiao, James Qiu, James Lulo, Jian Tang, Anne-Sophie Dugast, Ross B. Fulton, Galina Craig, Stephanie Grabow, Maja Razlog, James F. Sampson, Eric M. Tam, Sonia Feau, Alexander Koshkaryev, Neeraj Kohli, Kathy Zhang, Yang Jiao, Lia Luus, Adam Camblin, Jennifer Richards, Christina S. F. Wong, Daryl C. Drummond, James Suchy, Aniela Jakubowski, Michael Croft, Marco Muda, James D. Marks, Elizabeth Hutto, Vinodh B. Kurella, Yu Zhou, Andreas Raue, Hong Zhang, Lihui Xu, Fabien Dépis, Sandeep Kumar, Violette Paragas
Publikováno v:
Science Translational Medicine. 11
Tumor necrosis factor receptor 2 (TNFR2) is the alternate receptor for TNF and can mediate both pro- and anti-inflammatory activities of T cells. Although TNFR2 has been linked to enhanced suppressive activity of regulatory T cells (Tregs) in autoimm
Autor:
Eric M, Tam, Ross B, Fulton, James F, Sampson, Marco, Muda, Adam, Camblin, Jennifer, Richards, Alexander, Koshkaryev, Jian, Tang, Vinodh, Kurella, Yang, Jiao, Lihui, Xu, Kathy, Zhang, Neeraj, Kohli, Lia, Luus, Elizabeth, Hutto, Sandeep, Kumar, James, Lulo, Violette, Paragas, Christina, Wong, James, Suchy, Stephanie, Grabow, Anne-Sophie, Dugast, Hong, Zhang, Fabien, Depis, Sonia, Feau, Aniela, Jakubowski, Wenlian, Qiao, Galina, Craig, Maja, Razlog, James, Qiu, Yu, Zhou, James D, Marks, Michael, Croft, Daryl C, Drummond, Andreas, Raue
Publikováno v:
Science translational medicine. 11(512)
Tumor necrosis factor receptor 2 (TNFR2) is the alternate receptor for TNF and can mediate both pro- and anti-inflammatory activities of T cells. Although TNFR2 has been linked to enhanced suppressive activity of regulatory T cells (T
Autor:
Jonathan Fitzgerald, Gavin MacBeath, Aaron Fulgham, Victor Moyo, Brian Harms, Emily Pace, Art Kudla, Gregory J. Finn, Viara P. Grantcharova, Jeff Kearns, Kristina Masson, Bambang Adiwijaya, Michael D. Curley, Gabriela Garcia, Ulrik B. Nielsen, Birgit Schoeberl, Bill Kubasek, Jaeyeon Kim, Olga Burenkova, Rachel Nering, Marisa Wainszelbaum, Sara Mathews, Ashish Kalra, Defne Yarar, Violette Paragas, Akos Czibere, Kip A. West
Publikováno v:
NPJ Systems Biology and Applications
The ErbB family of receptor tyrosine kinases comprises four members: epidermal growth factor receptor (EGFR/ErbB1), human EGFR 2 (HER2/ErbB2), ErbB3/HER3, and ErbB4/HER4. The first two members of this family, EGFR and HER2, have been implicated in tu
Autor:
James F. Sampson, Vinodh B. Kurella, Violette Paragas, Sandeep Kumar, James E. Lulo, James A. Qiu, Maja Razlog, Ross B. Fulton, Adam J. Camblin, Jennifer M. Richards, Christina S. Wong, Alexander Koshkaryev, James J. Suchy, Stephanie Grabow, Marco Muda, Andreas Raue, Daryl C. Drummond, Eric M. Tam
Publikováno v:
Cancer Research. 79:555-555
TNFR2 is an emerging therapeutic target in immuno-oncology. We have previously shown that an agonistic mouse TNFR2 antibody was able to activate CD8+ T cells in vitro and has anti-tumor activity in multiple syngeneic mouse tumor models. This activity