Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Violeta Zaric"'
Autor:
Shalini Kot, Subha Karumuthil-Melethil, Evan Woodley, Violeta Zaric, Patrick Thompson, Zhilin Chen, Erik Lykken, John G. Keimel, William F. Kaemmerer, Steven J. Gray, Jagdeep S. Walia
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6751 (2021)
GM2 gangliosidosis disorders are a group of neurodegenerative diseases that result from a functional deficiency of the enzyme β-hexosaminidase A (HexA). HexA consists of an α- and β-subunit; a deficiency in either subunit results in Tay–Sachs Di
Externí odkaz:
https://doaj.org/article/466f52285cfe442f99f9974dfd0081d6
Autor:
Sarah E. Sinnett, Ralph D. Hector, Kamal K.E. Gadalla, Clifford Heindel, Daphne Chen, Violeta Zaric, Mark E.S. Bailey, Stuart R. Cobb, Steven J. Gray
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 5, Iss C, Pp 106-115 (2017)
Intravenous administration of adeno-associated virus serotype 9 (AAV9)/hMECP2 has been shown to extend the lifespan of Mecp2−/y mice, but this delivery route induces liver toxicity in wild-type (WT) mice. To reduce peripheral transgene expression,
Externí odkaz:
https://doaj.org/article/4e66309230e84338a6ba9fd000c7402a
Autor:
Matthew L. Hirsch, Violeta Zaric, Brian C. Gilger, Laura Conatser, Telmo Llanga, Liujiang Song
Publikováno v:
Gene Therapy. 25:402-414
AAV gene therapy approaches in the posterior eye resulted in the first FDA-approved gene therapy-based drug. However, application of AAV vectorology to the anterior eye has yet to enter even a Phase I trial. Furthermore, the simple and safe subconjun
Autor:
Ernesto R. Bongarzone, Richard B. van Breemen, Vince Elackattu, Benas Jakubauskas, Yazan Issa, Subha Karumuthil-Melethil, Maarten C. Bosland, Stephen J. Crocker, Duc Nguyen, Zane Hauck, Jeffrey N. Marshall, Violeta Zaric, Emily A. Rue, Monika Stoskute, Michael S. Marshall, Wil Bogue, Steven J. Gray, Maria I. Givogri
Publikováno v:
Molecular Therapy. 26:874-889
We report a global adeno-associated virus (AAV)9-based gene therapy protocol to deliver therapeutic galactosylceramidase (GALC), a lysosomal enzyme that is deficient in Krabbe’s disease. When globally administered via intrathecal, intracranial, and
Publikováno v:
Journal of Comparative Neurology. 524:2400-2417
Activation of M2 muscarinic receptors (M2Rs) in the rat anterior basolateral nucleus (BLa) is critical for the consolidation of memories of emotionally arousing events. The present investigation used immunocytochemistry at the electron microscopic le
Autor:
Violeta Zaric, Alexander J. McDonald
Publikováno v:
Neuroscience. 290:227-242
The entorhinal cortex and other hippocampal and parahippocampal cortices are interconnected by a small number of GABAergic nonpyramidal neurons in addition to glutamatergic pyramidal cells. Since the cortical and basolateral amygdalar nuclei have cor
Publikováno v:
Inflammatory Bowel Diseases. 21:485-495
BACKGROUND Intestinal inflammation in inflammatory bowel diseases is driven by abnormal levels of proinflammatory cytokines, where tumor necrosis factor (TNF)-α seems to be particularly important. Chronic inflammatory signaling in the colon increase
Autor:
Mark E.S. Bailey, Steven J. Gray, Clifford Heindel, Daphne Chen, Kamal K.E. Gadalla, Violeta Zaric, Sarah E. Sinnett, Ralph D. Hector, Stuart Cobb
Publikováno v:
Sinnett, S E, Hector, R D, Gadalla, K K E, Heindel, C, Chen, D, Zaric, V, Bailey, M E S, Cobb, S R & Gray, S J 2017, ' Improved MECP2 gene therapy extends the survival of MeCP2-null mice without apparent toxicity after intracisternal delivery ', Molecular Therapy-Methods and Clinical Development, vol. 5, pp. 106-115 . https://doi.org/10.1016/j.omtm.2017.04.006
Molecular Therapy: Methods & Clinical Development, Vol 5, Iss C, Pp 106-115 (2017)
Molecular Therapy: Methods & Clinical Development, Vol 5, Iss C, Pp 106-115 (2017)
Intravenous administration of adeno-associated virus serotype 9 (AAV9)/ hMECP2 has been shown to extend the lifespan of Mecp2 −/y mice, but this delivery route induces liver toxicity in wild-type (WT) mice. To reduce peripheral transgene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534f62ede21a1ed4b095c8c9075d3775
https://eprints.gla.ac.uk/139919/7/139919.pdf
https://eprints.gla.ac.uk/139919/7/139919.pdf
Autor:
Sarah E, Sinnett, Ralph D, Hector, Kamal K E, Gadalla, Clifford, Heindel, Daphne, Chen, Violeta, Zaric, Mark E S, Bailey, Stuart R, Cobb, Steven J, Gray
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Intravenous administration of adeno-associated virus serotype 9 (AAV9)/hMECP2 has been shown to extend the lifespan of Mecp2−/y mice, but this delivery route induces liver toxicity in wild-type (WT) mice. To reduce peripheral transgene expression,
Publikováno v:
Journal of Comparative Neurology. 521:1743-1759
Muscarinic neurotransmission in the anterior basolateral amygdalar nucleus (BLa) mediated by the M1 receptor (M1R) is critical for memory consolidation. Although knowledge of the subcellular localization of M1R in the BLa would contribute to an under