Hakai is required for stabilization of core components of the m6A mRNA methylation machinery

Autor: Praveen Bawankar, Tina Lence, Chiara Paolantoni, Irmgard U. Haussmann, Migle Kazlauskiene, Dominik Jacob, Jan B. Heidelberger, Florian M. Richter, Mohanakarthik P. Nallasivan, Violeta Morin, Nastasja Kreim, Petra Beli, Mark Helm, Martin Jinek, Matthias Soller, Jean-Yves Roignant

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

The E3 ligase Hakai can interact with the m6A methylation machinery but its function is still unclear. Here, the authors show that Hakai is a conserved component of the m6A methyltransferase complex and provide functional and molecular insights into

Externí odkaz: https://doaj.org/article/fecec708c84b4bd4904def2c94ce32a6

Comprehensive Characterization of the Complex lola Locus Reveals a Novel Role in the Octopaminergic Pathway via Tyramine Beta-Hydroxylase Regulation

Autor: Nadja Dinges, Violeta Morin, Nastasja Kreim, Tony D. Southall, Jean-Yves Roignant

Publikováno v: Cell Reports, Vol 21, Iss 10, Pp 2911-2925 (2017)

Summary: Longitudinals lacking (lola) is one of the most complex genes in Drosophila melanogaster, encoding up to 20 protein isoforms that include key transcription factors involved in axonal pathfinding and neural reprogramming. Most previous studie

Externí odkaz: https://doaj.org/article/ec501e09afa24712afb98fcaebfa1f62

The protease degrading sperm histones post-fertilization in sea urchin eggs is a nuclear cathepsin L that is further required for embryo development.

Autor: Violeta Morin, Andrea Sanchez-Rubio, Antoine Aze, Claudio Iribarren, Claire Fayet, Yves Desdevises, Jenaro Garcia-Huidobro, Maria Imschenetzky, Marcia Puchi, Anne-Marie Genevière

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e46850 (2012)

Proteolysis of sperm histones in the sea urchin male pronucleus is the consequence of the activation at fertilization of a maternal cysteine protease. We previously showed that this protein is required for male chromatin remodelling and for cell-cycl

Externí odkaz: https://doaj.org/article/260c1f1456b54cd79ca37c6ec53ce44c

Effects of salinity changes on hatching, hatching-gene expression, and hatching-enzyme expression in anchoveta Engraulis ringens eggs

Autor: Violeta Morin, Samuel Soto, Matías Gonzalez, Andrea Miranda, Leonardo R. Castro, Oger Tiznado

Publikováno v: Marine Ecology Progress Series. 658:181-194

The Peruvian anchoveta Engraulis ringens is one of the most important commercial fishes along the Humboldt Current. Previous studies have shown that egg quality (volume, protein and lipid content) and hatching rates decrease during the spawning seaso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac9b43beadcca90e328f7aca94853900
https://doi.org/10.3354/meps13548

Variants in PUS7 Cause Intellectual Disability with Speech Delay, Microcephaly, Short Stature, and Aggressive Behavior

Autor: F. Lucy Raymond, Lonneke de Boer, Michal Minczuk, Rami Abou Jamra, Nadja Dinges, Modi Safra, Zubair M. Ahmed, Detilina Grozeva, Hans van Bokhoven, Pedro Rebelo-Guiomar, Mohsin Shahzad, Clara Soyris, Violeta Morin, Mureed Hussain, Nadine Körtel, Michael Stock, Saima Riazuddin, Daniel L. Polla, Jean-Yves Roignant, Arjan P.M. de Brouwer, Avia Zisso, André Reis, Schraga Schwartz, Christopher A. Powell, David A. Koolen, Sheikh Riazuddin, Rolph Pfundt, Franziska Schwarz

Publikováno v: The American Journal of Human Genetics
American Journal of Human Genetics, 103, 1045-1052
American Journal of Human Genetics, 103, 6, pp. 1045-1052

We describe six persons from three families with three homozygous protein truncating variants in PUS7: c.89_90del (p.Thr30Lysfs(∗)20), c.1348C>T (p.Arg450(∗)), and a deletion of the penultimate exon 15. All these individuals have intellectual dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffde4fc4129ca32880c4e40085b728c
https://doi.org/10.1016/j.ajhg.2018.10.026